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Cldn6 Gene Detail
Summary
  • Symbol
    Cldn6
  • Name
    claudin 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859284
    NCBI Gene: 54419
  • Gene Overview
    MyGene.info: CLDN6
Location & Maps
more
  • Sequence Map
    Chr17:23679365-23682446 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3082 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 11.99 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CLDN6, claudin 6
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CLDN6, claudin 6
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 9074
    neXtProt AC: NX_P56747

  • Chr Location
    16p13.3; chr16:3014712-3018187 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotypes from multigenic genotypes
    3 images
    9 phenotype references
  • All Mutations and Alleles
    6
  • Gene trapped
    3
  • Targeted
    3
  • Incidental Mutations
Mice homozygous for a null allele do not exhibit overt abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033036 VEGA Gene Model | MGI Sequence Detail 3082 C57BL/6J ±  kb
transcript OTTMUST00000082451 VEGA | MGI Sequence Detail 1506 Not Applicable  
polypeptide OTTMUSP00000044180 VEGA | MGI Sequence Detail 219 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    14 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 49
    cDNA 45
    Primer pair 2
    Other 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:2146955
References
more
  • Summaries
    All 58
    Developmental Gene Expression 20
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:58914 Itoh M, et al., Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol. 1999 Dec 13;147(6):1351-63
  • Latest
    J:229177 Jimenez FR, et al., Conditional pulmonary over-expression of Claudin 6 during embryogenesis delays lung morphogenesis. Int J Dev Biol. 2015;59(10-11-12):479-485

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory