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Cldn6 Gene Detail
Summary
  • Symbol
    Cldn6
  • Name
    claudin 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859284
    NCBI Gene: 54419
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:23898345-23901417 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 11.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    14 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859284
 protein coding gene Chr17:23898223-23901420 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023264
 protein coding gene Chr17:22594736-22597822 (+)
A/J MGP_AJ_G0023224
 protein coding gene Chr17:21944998-21948084 (+)
AKR/J MGP_AKRJ_G0023194
 protein coding gene Chr17:22021320-22024401 (+)
BALB/cJ MGP_BALBcJ_G0023229
 protein coding gene Chr17:22159426-22162512 (+)
C3H/HeJ MGP_C3HHeJ_G0022989
 protein coding gene Chr17:22382827-22385908 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023672
 protein coding gene Chr17:23576254-23579335 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021153
 protein coding gene Chr17:19514032-19517120 (+)
CAST/EiJ MGP_CASTEiJ_G0022495
 protein coding gene Chr17:22215699-22218793 (+)
CBA/J MGP_CBAJ_G0022965
 protein coding gene Chr17:24386608-24389689 (+)
DBA/2J MGP_DBA2J_G0023097
 protein coding gene Chr17:21573476-21576562 (+)
FVB/NJ MGP_FVBNJ_G0023064
 protein coding gene Chr17:21297944-21301025 (+)
LP/J MGP_LPJ_G0023171
 protein coding gene Chr17:22852828-22855914 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023083
 protein coding gene Chr17:24149128-24152214 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023711
 protein coding gene Chr17:22314615-22317701 (+)
PWK/PhJ MGP_PWKPhJ_G0022243
 protein coding gene Chr17:20358973-20362067 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022063
 protein coding gene Chr17:20338447-20341674 (+)
WSB/EiJ MGP_WSBEiJ_G0022558
 protein coding gene Chr17:22369813-22372894 (+)



Homology
more
  • Human Ortholog
    CLDN6, claudin 6
  • Vertebrate Orthologs
    9
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLDN6, claudin 6
  • Links
    NCBI Gene ID: 9074
    neXtProt AC: NX_P56747
    UniProt: P56747

  • Chr Location
    16p13.3; chr16:3014712-3020071 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotypes from multigenic genotypes
    3 images
    11 phenotype references
Mice homozygous for a null allele do not exhibit overt abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    902
  • Tissues
    156
  • cDNA Data
    47
  • Literature Summary
    27
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 54419 NCBI Gene Model | MGI Sequence Detail 3073 C57BL/6J ±  kb
transcript NM_018777 RefSeq | MGI Sequence Detail 1497 C57BL/6  
polypeptide Q9Z262 UniProt | EBI | MGI Sequence Detail 219 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 55
    cDNA 47
    Primer pair 5
    Other 3

    Microarray probesets 5
Other
Accession IDs
less
MGI:2146955
References
more
  • Summaries
    All 74
    Developmental Gene Expression 27
    Gene Ontology 10
    Phenotypes 11
  • Earliest
    J:58914 Itoh M, et al., Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol. 1999 Dec 13;147(6):1351-63
  • Latest
    J:327183 Gu R, et al., Single-cell transcriptomic signatures and gene regulatory networks modulated by Wls in mammalian midline facial formation and clefts. Development. 2022 Jul 15;149(14):dev200533
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory