Hgfac
Gene Detail

Symbol Name ID

Hgfac hepatocyte growth factor activator MGI:1859281

Synonyms

HGFA

Feature Type

protein coding gene

Genetic Map

Chromosome 5

17.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:35041553-35048436 bp, + strand From NCBI annotation of GRCm38   6884 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1170  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: coagulation factor XII/hepatocyte growth factor activator
Gene Tree: Hgfac

Human homologs

Human Homolog		HGFAC, HGF activator
NCBI Gene ID		3083
neXtProt AC		NX_Q04756
Human Synonyms		HGFA
Human Chr (Location)		4p16; chr4:3443726-3451213 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous null mice display impaired intestinal regeneration and increased mortality after intestinal injury.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	proteolysis
Component	cytoplasm, extracellular region, ...
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (36)    Tissues (16)    Images (25)
Theiler Stages: 10, 18, 20, 22, 23, 25, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	21
Northern blot	13

cDNA source data(40)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(41) cDNA(41)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000029102 (Evidence)
Entrez Gene	54426 (Evidence)
UniGene	27369
DFCI	TC1580240, TC1662709
DoTS	DT.101277328, DT.490513, DT.94267013, DT.97379091
NIA Mouse Gene Index	U005495
EC	3.4.21.-
Consensus CDS Project	CCDS19223.1
International Mouse Knockout Project Status	Hgfac

Sequences

Length	Strain/Species
genomic	54426	NCBI Gene Model | MGI Sequence Detail	6884	C57BL/6J
transcript	NM_019447	RefSeq | MGI Sequence Detail	2103	C57BL/6
polypeptide	Q9R098	UniProt | EBI | MGI Sequence Detail	653	Not Applicable

All sequences(42) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(50 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR014394	Coagulation factor XIIa/hepatocyte growth factor activator
InterPro	IPR016060	Complement control module
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR000083	Fibronectin, type I
InterPro	IPR000562	Fibronectin, type II, collagen-binding
InterPro	IPR000001	Kringle
InterPro	IPR018056	Kringle, conserved site
InterPro	IPR013806	Kringle-like fold
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site
Protein Ontology	PR:000008535	hepatocyte growth factor activator

Graphical View of Protein Domain Structure

References

(Earliest) J:61721 Itoh H, et al., Mouse hepatocyte growth factor activator gene: its expression not only in the liver but also in the gastrointestinal tract(1). Biochim Biophys Acta. 2000 Apr 25;1491(1-3):295-302
(Latest) J:193731 Yamagata Y, et al., Loss of HGF activator inhibits foveolar hyperplasia induced by oxyntic atrophy without altering gastrin levels. Am J Physiol Gastrointest Liver Physiol. 2012 Dec 1;303(11):G1254-61
All references(37)