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Hgfac
Gene Detail
 Symbol
Name
ID
Hgfac
hepatocyte growth factor activator
MGI:1859281
Synonyms HGFA
Feature Type protein coding gene
Genetic Map
Chromosome 5
17.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:35041553-35048436 bp, + strand
From NCBI annotation of GRCm38

  6884 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1170  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: coagulation factor XII/hepatocyte growth factor activator
Gene Tree: Hgfac

Human
homologs
Human Homolog HGFAC, HGF activator
NCBI Gene ID 3083
neXtProt AC  NX_Q04756
Human Synonyms  HGFA
Human Chr (Location)  4p16; chr4:3441975-3449491 (+)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display impaired intestinal regeneration and increased mortality after intestinal injury.
 
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process proteolysis
Component cytoplasm, extracellular region, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (36)    Tissues (16)    Images (25)
Theiler Stages: 10, 18, 20, 22, 23, 25, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 21
Northern blot 13
cDNA source data(40)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(41) cDNA(41)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000029102 (Evidence)
Entrez Gene54426 (Evidence)
UniGene27369
DFCITC1580240, TC1662709
DoTSDT.101277328, DT.490513, DT.94267013, DT.97379091
NIA Mouse Gene IndexU005495
EC3.4.21.-
Consensus CDS ProjectCCDS19223.1
International Mouse Knockout Project StatusHgfac
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 54426 NCBI Gene Model | MGI Sequence Detail 6884 C57BL/6J ±  kb
transcript NM_019447 RefSeq | MGI Sequence Detail 2103 C57BL/6 
polypeptide Q9R098 UniProt | EBI | MGI Sequence Detail 653 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(12) UniProt(5)
Polymorphisms SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014394 Coagulation factor XIIa/hepatocyte growth factor activator
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR000083 Fibronectin, type I
InterPro IPR000562 Fibronectin, type II, collagen-binding
InterPro IPR000001 Kringle
InterPro IPR018056 Kringle, conserved site
InterPro IPR013806 Kringle-like fold
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000008535 hepatocyte growth factor activator
Graphical View of Protein Domain Structure
References (Earliest) J:61721 Itoh H, et al., Mouse hepatocyte growth factor activator gene: its expression not only in the liver but also in the gastrointestinal tract(1). Biochim Biophys Acta. 2000 Apr 25;1491(1-3):295-302
(Latest) J:193731 Yamagata Y, et al., Loss of HGF activator inhibits foveolar hyperplasia induced by oxyntic atrophy without altering gastrin levels. Am J Physiol Gastrointest Liver Physiol. 2012 Dec 1;303(11):G1254-61
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory