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Pdlim3
Gene Detail
Symbol

Name
ID
Pdlim3
PDZ and LIM domain 3
MGI:1859274
Synonyms
ALP
Feature Type
protein coding gene
Genetic Map
Chromosome 8
25.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:45885485-45919546 bp, + strand
From Ensembl annotation of GRCm38

  34062 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:75063  Vertebrate Homology Class
1 mouse; 1 cattle; 1 chicken; 1 zebrafish

HCOP human homology predictions: PDLIM3
Protein SuperFamily: PDZ and LIM domain protein
Gene Tree: Pdlim3

Human
homologs
PDLIM3, PDZ and LIM domain 3
Orthology source: HGNC

IDs:
NCBI Gene ID: 27295
neXtProt AC: NX_Q53GG5

Human Synonyms: ALP

Human Chr (Location): 4q35; chr4:185500660-185535607 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a knock-out allele show no major defects in skeletal muscle. However, homozygotes for another knock-out allele show partial background-sensitive prenatal lethality, embryonic right ventricular (RV) dilation and dysplasia, hypotrabeculation, and RV cardiomyopathy in surviving adults.
 
Interactions
Pdlim3 interacts with 78 markers (Mir7-2, Mir7b, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process actin filament organization, heart development
Component actin cytoskeleton, cytoplasm, ...
Function cytoskeletal protein binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (78)    Tissues (65)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 78
cDNA source data(66)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PDLIM3 ; Xenbase pdlim3 ; ZFIN pdlim3a, pdlim3b    NEW 
Molecular
reagents
All nucleic(66) cDNA(66)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000031636 (Evidence)
Entrez Gene 53318 (Evidence)
UniGene 282900
DFCI TC1577676
DoTS DT.99838973, DT.534948
NIA Mouse Gene Index U009305
PDB 1X64, 1V5L
Consensus CDS Project CCDS22281.1
International Mouse Phenotyping Consortium Status Pdlim3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031636 Ensembl Gene Model | MGI Sequence Detail 34062 C57BL/6J ±  kb
transcript ENSMUST00000034053 Ensembl | MGI Sequence Detail 1578 Not Applicable 
polypeptide ENSMUSP00000034053 Ensembl | MGI Sequence Detail 316 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(261 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001478 PDZ domain
InterPro IPR006643 ZASP
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000012510 PDZ and LIM domain protein 3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:217538 Lui JH, et al., Radial glia require PDGFD-PDGFRbeta signalling in human but not mouse neocortex. Nature. 2014 Nov 13;515(7526):264-8
All references(37)
Other
accession IDs
MGI:2142561

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory