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Pdlim3 Gene Detail
Summary
  • Symbol
    Pdlim3
  • Name
    PDZ and LIM domain 3
  • Synonyms
    ALP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859274
    NCBI Gene: 53318
  • Gene Overview
    MyGene.info: PDLIM3
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:45885461-45919548 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 25.86 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    261 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859274
protein coding gene Chr8:45885452-45919548 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033578
protein coding gene Chr8:44956731-44994603 (+)
A/J MGP_AJ_G0033560
protein coding gene Chr8:43230391-43267084 (+)
AKR/J MGP_AKRJ_G0033485
protein coding gene Chr8:44489963-44529321 (+)
BALB/cJ MGP_BALBcJ_G0033557
protein coding gene Chr8:43406424-43446383 (+)
C3H/HeJ MGP_C3HHeJ_G0033266
protein coding gene Chr8:45020623-45055069 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034073
protein coding gene Chr8:46662971-46700818 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031022
protein coding gene Chr8:39507950-39539332 (+)
CAST/EiJ MGP_CASTEiJ_G0032592
protein coding gene Chr8:44463901-44498134 (+)
CBA/J MGP_CBAJ_G0033245
protein coding gene Chr8:48542986-48587194 (+)
DBA/2J MGP_DBA2J_G0033398
protein coding gene Chr8:43036492-43070235 (+)
FVB/NJ MGP_FVBNJ_G0033339
protein coding gene Chr8:42531040-42567491 (+)
LP/J MGP_LPJ_G0033486
protein coding gene Chr8:44976469-45009768 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033384
protein coding gene Chr8:48624998-48663883 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034091
protein coding gene Chr8:44656011-44693855 (+)
PWK/PhJ MGP_PWKPhJ_G0032300
protein coding gene Chr8:42565358-42598514 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032136
protein coding gene Chr8:43812055-43848127 (+)
WSB/EiJ MGP_WSBEiJ_G0032708
protein coding gene Chr8:44913901-44950649 (+)



Homology
more
  • Human Ortholog
    PDLIM3, PDZ and LIM domain 3
  • Vertebrate Orthologs
    4
  • Human Ortholog
    PDLIM3, PDZ and LIM domain 3
    Orthology source: HGNC
  • Synonyms
    ALP
  • Links
    NCBI Gene ID: 27295
    neXtProt AC: NX_Q53GG5
    UniProt: Q53GG5

  • Chr Location
    4q35.1; chr4:185500660-185535606 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Pdlim3 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a knock-out allele show no major defects in skeletal muscle. However, homozygotes for another knock-out allele show partial background-sensitive prenatal lethality, embryonic right ventricular (RV) dilation and dysplasia, hypotrabeculation, and RV cardiomyopathy in surviving adults.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031636 Ensembl Gene Model | MGI Sequence Detail 34088 C57BL/6J ±  kb
    transcript ENSMUST00000210422 Ensembl | MGI Sequence Detail 1479 Not Applicable  
    polypeptide ENSMUSP00000148113 Ensembl | MGI Sequence Detail 364 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 68
      cDNA 68

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2142561
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:71343 Xia H, et al., Actinin-associated LIM protein: identification of a domain interaction between PDZ and spectrin-like repeat motifs. J Cell Biol. 1997 Oct 20;139(2):507-15
    • Latest
      J:243708 Bang ML, Animal Models of Congenital Cardiomyopathies Associated With Mutations in Z-Line Proteins. J Cell Physiol. 2017 Jan;232(1):38-52

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    01/15/2019
    MGI 6.13
    The Jackson Laboratory