About   Help   FAQ
Pdlim3
Gene Detail
 Symbol
Name
ID
Pdlim3
PDZ and LIM domain 3
MGI:1859274
Synonyms ALP
Feature Type protein coding gene
Genetic Map
Chromosome 8
25.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:45885485-45919546 bp, + strand
From NCBI annotation of GRCm38

  34062 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:75063  Vertebrate Homology Class
1 mouse; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: PDZ and LIM domain protein
Gene Tree: Pdlim3

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a knock-out allele show no major defects in skeletal muscle. However, homozygotes for another knock-out allele show partial background-sensitive prenatal lethality, embryonic right ventricular (RV) dilation and dysplasia, hypotrabeculation, and RV cardiomyopathy in surviving adults.
 
Interactions
Pdlim3 interacts with 79 markers (Mir7-2, Mir7b, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process actin filament organization, heart development
Component actin cytoskeleton, cytoplasm, ...
Function cytoskeletal protein binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (78)    Tissues (65)    Images (9)
Theiler Stages: 17, 21, 23, 24, 27, 28
Assay TypeResults
RNA in situ 78
cDNA source data(66)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(66) cDNA(66)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000031636 (Evidence)
Entrez Gene53318 (Evidence)
UniGene282900
DFCITC1577676
DoTSDT.534948, DT.99838973
NIA Mouse Gene IndexU009305
PDB1V5L, 1X64
Consensus CDS ProjectCCDS22281.1
International Mouse Knockout Project StatusPdlim3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 53318 NCBI Gene Model | MGI Sequence Detail 34062 C57BL/6J ±  kb
transcript NM_016798 RefSeq | MGI Sequence Detail 1578 C57BL/6 
polypeptide O70209 UniProt | EBI | MGI Sequence Detail 316 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(261 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001478 PDZ domain
InterPro IPR006643 ZASP
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000012510 PDZ and LIM domain protein 3
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(37)
Other
accession IDs
MGI:2142561

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory