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Prss16 Gene Detail
Summary
  • Symbol
    Prss16
  • Name
    protease, serine 16 (thymus)
  • Synonyms
    TSSP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859181
    NCBI Gene: 54373
  • Gene Overview
    MyGene.info: PRSS16
Location & Maps
more
  • Sequence Map
    Chr13:22002176-22009742 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7567 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 8.12 cM, cytoband A3-A5
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    PRSS16, protease, serine 16
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRSS16, protease, serine 16
    Orthology source: HomoloGene
  • Synonyms
    TSSP
  • Links
    NCBI Gene ID: 10279
    neXtProt AC: NX_Q9NQE7

  • Chr Location
    6p21; chr6:27247723-27256620 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Prss16
  • Incidental Mutations
Homozygous null mice are viable with no gross abnormalities and normal T cell development and activation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000726 VEGA Gene Model | MGI Sequence Detail 7567 C57BL/6J ±  kb
transcript OTTMUST00000001360 VEGA | MGI Sequence Detail 2152 Not Applicable  
polypeptide OTTMUSP00000000643 VEGA | MGI Sequence Detail 509 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    151 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    Genomic 2
    cDNA 17

    Microarray probesets 3
Other
Accession IDs
less
MGI:2145239
References
more
  • Summaries
    All 34
    Gene Ontology 6
    Phenotypes 18
  • Earliest
    J:62615 Carrier A, et al., Differential gene expression in CD3epsilon- and RAG1-deficient thymuses: definition of a set of genes potentially involved in thymocyte maturation. Immunogenetics. 1999 Dec;50(5-6):255-70
  • Latest
    J:229782 Serre L, et al., Central tolerance spares the private high-avidity CD4(+) T-cell repertoire specific for an islet antigen in NOD mice. Eur J Immunol. 2015 Jul;45(7):1946-56

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory