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Irf3 Gene Detail
Summary
  • Symbol
    Irf3
  • Name
    interferon regulatory factor 3
  • Synonyms
    C920001K05Rik, IRF-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859179
    NCBI Gene: 54131
  • Gene Overview
    MyGene.info: IRF3
Location & Maps
more
  • Sequence Map
    Chr7:44997648-45002848 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5201 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    IRF3, interferon regulatory factor 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IRF3, interferon regulatory factor 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IIAE7
  • Links
    NCBI Gene ID: 3661
    neXtProt AC: NX_Q14653

  • Chr Location
    19q13.3-q13.4; chr19:49659569-49665875 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human IRF3 associations

Human Disease Mouse Models
       Herpes Simplex Encephalitis, Susceptibility to, 7   OMIM: 616532
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    117 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Gene trapped
    18
  • Targeted
    1
  • Incidental Mutations
Homozygous null mice are more susceptible to viral infection and exhibit lower serum interferon levels in response to viral infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020438 VEGA Gene Model | MGI Sequence Detail 5201 C57BL/6J ±  kb
transcript OTTMUST00000048513 VEGA | MGI Sequence Detail 2031 Not Applicable  
polypeptide OTTMUSP00000022256 VEGA | MGI Sequence Detail 419 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    65 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000002045 interferon regulatory factor 3
  • InterPro Domains
    IPR019471 Interferon regulatory factor-3
    IPR019817 Interferon regulatory factor, conserved site
    IPR001346 Interferon regulatory factor DNA-binding domain
    IPR017855 SMAD domain-like
    IPR008984 SMAD/FHA domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 15
    cDNA 14
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:2441924
References
more
  • Summaries
    All 181
    Developmental Gene Expression 8
    Gene Ontology 16
    Phenotypes 117
  • Earliest
    J:62618 Bellingham J, et al., Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker. Ann Hum Genet. 1998 May;62(Pt 3):231-4
  • Latest
    J:228986 Temizoz B, et al., TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN. Eur J Immunol. 2015 Apr;45(4):1159-69

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory