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Irf3 Gene Detail
Summary
  • Symbol
    Irf3
  • Name
    interferon regulatory factor 3
  • Synonyms
    C920001K05Rik, IRF-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859179
    NCBI Gene: 54131
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44647072-44652272 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.07 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    65 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859179
 protein coding gene Chr7:44647072-44652272 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032192
 protein coding gene Chr7:45222098-45228669 (+)
A/J MGP_AJ_G0032171
 protein coding gene Chr7:44365470-44370462 (+)
AKR/J MGP_AKRJ_G0032107
 protein coding gene Chr7:45591576-45598333 (+)
BALB/cJ MGP_BALBcJ_G0032183
 protein coding gene Chr7:44363584-44368674 (+)
C3H/HeJ MGP_C3HHeJ_G0031899
 protein coding gene Chr7:46093795-46098901 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032675
 protein coding gene Chr7:47483211-47488468 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029689
 protein coding gene Chr7:46932734-46937766 (+)
CAST/EiJ MGP_CASTEiJ_G0031227
 protein coding gene Chr7:37463625-37469447 (+)
CBA/J MGP_CBAJ_G0031863
 protein coding gene Chr7:49045926-49050989 (+)
DBA/2J MGP_DBA2J_G0032021
 protein coding gene Chr7:44036985-44042108 (+)
FVB/NJ MGP_FVBNJ_G0031972
 protein coding gene Chr7:43813857-43820167 (+)
LP/J MGP_LPJ_G0032099
 protein coding gene Chr7:45898463-45903630 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032009
 protein coding gene Chr7:47767841-47772956 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032691
 protein coding gene Chr7:44811438-44816977 (+)
PWK/PhJ MGP_PWKPhJ_G0030950
 protein coding gene Chr7:37401396-37406376 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030787
 protein coding gene Chr7:32818927-32823916 (+)
WSB/EiJ MGP_WSBEiJ_G0031344
 protein coding gene Chr7:45288242-45293832 (+)



Homology
more
  • Human Ortholog
    IRF3, interferon regulatory factor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRF3, interferon regulatory factor 3
  • Synonyms
    IIAE7
  • Links
    NCBI Gene ID: 3661
    neXtProt AC: NX_Q14653
    UniProt: Q14653

  • Chr Location
    19q13.33; chr19:49659569-49665875 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IRF3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    21 phenotypes from multigenic genotypes
    242 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are more susceptible to viral infection and exhibit lower serum interferon levels in response to viral infection. Knockout also results in progressive retinal degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    77
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    782
  • Tissues
    66
  • cDNA Data
    14
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54131 NCBI Gene Model | MGI Sequence Detail 5201 C57BL/6J ±  kb
    transcript NR_045611 RefSeq | MGI Sequence Detail 2211 C57BL/6  
    polypeptide P70671 UniProt | EBI | MGI Sequence Detail 419 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 15
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2441924
    References
    more
    • Summaries
      All 362
      Developmental Gene Expression 11
      Gene Ontology 26
      Phenotypes 242
    • Earliest
      J:62618 Bellingham J, et al., Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker. Ann Hum Genet. 1998 May;62(Pt 3):231-4
    • Latest
      J:341613 Bourdon M, et al., Susceptibility to Zika virus in a Collaborative Cross mouse strain is induced by Irf3 deficiency in vitro but requires other variants in vivo. PLoS Pathog. 2023 Sep;19(9):e1011446
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory