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Irf3 Gene Detail
Summary
  • Symbol
    Irf3
  • Name
    interferon regulatory factor 3
  • Synonyms
    C920001K05Rik, IRF-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859179
    NCBI Gene: 54131
  • Gene Overview
    MyGene.info: IRF3
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44997648-45002848 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.07 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    65 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859179
protein coding gene Chr7:44997648-45002848 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032192
protein coding gene Chr7:45222098-45228669 (+)
A/J MGP_AJ_G0032171
protein coding gene Chr7:44365470-44370462 (+)
AKR/J MGP_AKRJ_G0032107
protein coding gene Chr7:45591576-45598333 (+)
BALB/cJ MGP_BALBcJ_G0032183
protein coding gene Chr7:44363584-44368674 (+)
C3H/HeJ MGP_C3HHeJ_G0031899
protein coding gene Chr7:46093795-46098901 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032675
protein coding gene Chr7:47483211-47488468 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029689
protein coding gene Chr7:46932734-46937766 (+)
CAST/EiJ MGP_CASTEiJ_G0031227
protein coding gene Chr7:37463625-37469447 (+)
CBA/J MGP_CBAJ_G0031863
protein coding gene Chr7:49045926-49050989 (+)
DBA/2J MGP_DBA2J_G0032021
protein coding gene Chr7:44036985-44042108 (+)
FVB/NJ MGP_FVBNJ_G0031972
protein coding gene Chr7:43813857-43820167 (+)
LP/J MGP_LPJ_G0032099
protein coding gene Chr7:45898463-45903630 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032009
protein coding gene Chr7:47767841-47772956 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032691
protein coding gene Chr7:44811438-44816977 (+)
PWK/PhJ MGP_PWKPhJ_G0030950
protein coding gene Chr7:37401396-37406376 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030787
protein coding gene Chr7:32818927-32823916 (+)
WSB/EiJ MGP_WSBEiJ_G0031344
protein coding gene Chr7:45288242-45293832 (+)



Homology
more
  • Human Ortholog
    IRF3, interferon regulatory factor 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IRF3, interferon regulatory factor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IIAE7
  • Links
    NCBI Gene ID: 3661
    neXtProt AC: NX_Q14653
    UniProt: Q14653

  • Chr Location
    19q13.33; chr19:49659569-49665875 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    148 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice are more susceptible to viral infection and exhibit lower serum interferon levels in response to viral infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 54131 NCBI Gene Model | MGI Sequence Detail 5201 C57BL/6J ±  kb
transcript NR_045611 RefSeq | MGI Sequence Detail 2211 C57BL/6  
polypeptide P70671 UniProt | EBI | MGI Sequence Detail 419 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000002045 interferon regulatory factor 3
  • InterPro Domains
    IPR019471 Interferon regulatory factor-3
    IPR019817 Interferon regulatory factor, conserved site
    IPR001346 Interferon regulatory factor DNA-binding domain
    IPR008984 SMAD/FHA domain superfamily
    IPR017855 SMAD-like domain superfamily
    IPR036390 Winged helix DNA-binding domain superfamily
    IPR036388 Winged helix-like DNA-binding domain superfamily
Molecular
Reagents
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  • All nucleic 16
    cDNA 15
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:2441924
References
more
  • Summaries
    All 250
    Developmental Gene Expression 8
    Gene Ontology 21
    Phenotypes 148
  • Earliest
    J:62618 Bellingham J, et al., Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker. Ann Hum Genet. 1998 May;62(Pt 3):231-4
  • Latest
    J:265099 Cheng WY, et al., The cGas-Sting Signaling Pathway Is Required for the Innate Immune Response Against Ectromelia Virus. Front Immunol. 2018;9:1297

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory