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Irf3
Gene Detail
Symbol

Name
ID
Irf3
interferon regulatory factor 3
MGI:1859179
Synonyms
C920001K05Rik, IRF-3
Feature Type
protein coding gene
Genetic Map
Chromosome 7
29.07 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:44997648-45002848 bp, + strand
From VEGA annotation of GRCm38

  5201 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1208  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 3 western clawed frog; 1 zebrafish

Protein SuperFamily: interferon regulatory factor 3-9
Gene Tree: Irf3

Human
homologs
Human Homolog IRF3, interferon regulatory factor 3
NCBI Gene ID 3661
neXtProt AC  NX_Q14653
Human Chr (Location)  19q13.3-q13.4; chr19:49659569-49665875 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(18) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are more susceptible to viral infection and exhibit lower serum interferon levels in response to viral infection.
 
Interactions
Irf3 interacts with 69 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process defense response to virus, immune system process, ...
Component cytoplasm, nucleus
Function DNA binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (55)    Tissues (55)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 47
RT-PCR 8
cDNA source data(13)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(14) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000020438 (Evidence)
Ensembl Gene ModelENSMUSG00000003184 (Evidence)
Entrez Gene54131 (Evidence)
DFCITC1575567, TC1605329, TC1619920, TC1619925, TC1637370, TC1701652
DoTSDT.101328651, DT.101407834, DT.110985578, DT.495175, DT.91599138, DT.94369855
NIA Mouse Gene IndexU008060
Consensus CDS ProjectCCDS21224.1
International Mouse Knockout Project StatusIrf3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020438 VEGA Gene Model | MGI Sequence Detail 5201 C57BL/6J ±  kb
transcript OTTMUST00000048517 VEGA | MGI Sequence Detail 1429 Not Applicable 
polypeptide OTTMUSP00000022258 VEGA | MGI Sequence Detail 419 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(7) UniProt(4)
Polymorphisms
SNPs within 2kb(65 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019471 Interferon regulatory factor-3
InterPro IPR019817 Interferon regulatory factor, conserved site
InterPro IPR001346 Interferon regulatory factor DNA-binding domain
InterPro IPR017855 SMAD domain-like
InterPro IPR008984 SMAD/FHA domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000002045 interferon regulatory factor 3
References
(Earliest) J:62618 Bellingham J, et al., Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker. Ann Hum Genet. 1998 May;62(Pt 3):231-4
(Latest) J:210953 Spann KM, et al., IRF-3, IRF-7, and IPS-1 promote host defense against acute human metapneumovirus infection in neonatal mice. Am J Pathol. 2014 Jun;184(6):1795-806
All references(174)
Other
accession IDs
MGI:2441924

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory