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Irf3
Gene Detail
Symbol

Name
ID
Irf3
interferon regulatory factor 3
MGI:1859179
Synonyms
C920001K05Rik, IRF-3
Feature Type
protein coding gene
Genetic Map
Chromosome 7
29.07 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:44997648-45002848 bp, + strand
From VEGA annotation of GRCm38

  5201 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1208  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 3 western clawed frog; 1 zebrafish

HCOP human homology predictions: IRF3
Protein SuperFamily: interferon regulatory factor 3-9
Gene Tree: Irf3

Human
homologs
IRF3, interferon regulatory factor 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3661
neXtProt AC: NX_Q14653

Human Chr (Location): 19q13.3-q13.4; chr19:49659569-49665875 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(18) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are more susceptible to viral infection and exhibit lower serum interferon levels in response to viral infection.
 
Interactions
Irf3 interacts with 69 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process cellular response to lipopolysaccharide, defense response to virus, ...
Component cytoplasm, nucleus
Function DNA binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (55)    Tissues (55)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 47
RT-PCR 8
cDNA source data(13)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: ZFIN irf3    NEW 
Molecular
reagents
All nucleic(15) cDNA(14) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000020438 (Evidence)
Ensembl Gene Model ENSMUSG00000003184 (Evidence)
Entrez Gene 54131 (Evidence)
DFCI TC1701652, TC1637370, TC1575567, TC1619925, TC1619920, TC1605329
DoTS DT.110985578, DT.495175, DT.91599138, DT.101407834, DT.94369855, DT.101328651
NIA Mouse Gene Index U008060
Consensus CDS Project CCDS21224.1
International Mouse Phenotyping Consortium Status Irf3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020438 VEGA Gene Model | MGI Sequence Detail 5201 C57BL/6J ±  kb
transcript OTTMUST00000048513 VEGA | MGI Sequence Detail 2031 Not Applicable 
polypeptide OTTMUSP00000022256 VEGA | MGI Sequence Detail 419 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(7) UniProt(4)
Polymorphisms
SNPs within 2kb(65 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019471 Interferon regulatory factor-3
InterPro IPR019817 Interferon regulatory factor, conserved site
InterPro IPR001346 Interferon regulatory factor DNA-binding domain
InterPro IPR017855 SMAD domain-like
InterPro IPR008984 SMAD/FHA domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000002045 interferon regulatory factor 3
References
(Earliest) J:62618 Bellingham J, et al., Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker. Ann Hum Genet. 1998 May;62(Pt 3):231-4
(Latest) J:220964 Wang J, et al., Effective and lesion-free cutaneous influenza vaccination. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5005-10
All references(178)
Other
accession IDs
MGI:2441924

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory