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Cacng4 Gene Detail
Summary
  • Symbol
    Cacng4
  • Name
    calcium channel, voltage-dependent, gamma subunit 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859167
    NCBI Gene: 54377
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:107623183-107685383 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 70.29 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1777 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859167
 protein coding gene Chr11:107623183-107685532 (-)
129S1/SvImJ ENSMUSG00200032035
 protein coding gene Chr11:104930435-104992621 (-)
A/J ENSMUSG00195021734
 protein coding gene Chr11:104633865-104695734 (-)
AKR/J ENSMUSG00220033496
 protein coding gene Chr11:104846697-104908571 (-)
BALB/cJ ENSMUSG00180018499
 protein coding gene Chr11:104956042-105017922 (-)
C3H/HeJ ENSMUSG00175012532
 protein coding gene Chr11:104905026-104966886 (-)
C57BL/6NJ ENSMUSG00215013239
 protein coding gene Chr11:104469475-104531679 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017339
 protein coding gene Chr11:103647309-103708568 (-)
CAST/EiJ ENSTCUG00005038398
 protein coding gene Chr11:104366632-104428133 (-)
CBA/J ENSMUSG00210013186
 protein coding gene Chr11:104609905-104672086 (-)
DBA/2J ENSMUSG00185020386
 protein coding gene Chr11:104954771-105016637 (-)
FVB/NJ ENSMUSG00205021816
 protein coding gene Chr11:104751816-104813666 (-)
JF1/MsJ ENSUMUG00000007757
 protein coding gene Chr11:105223635-105285055 (-)
LP/J ENSMUSG00230033250
 protein coding gene Chr11:106006724-106068593 (-)
NOD/ShiLtJ ENSMUSG00190019493
 protein coding gene Chr11:104953268-105015135 (-)
NZO/HlLtJ ENSMUSG00225051893
 protein coding gene Chr11:108051274-108113142 (-)
PWK/PhJ ENSLUMG00010015451
 protein coding gene Chr11:104745104-104806697 (-)
SPRET/EiJ ENSMSPG00010036657
 protein coding gene Chr11:105235910-105296934 (-)
WSB/EiJ ENSIUOG00005016361
 protein coding gene Chr11:104735592-104797531 (-)



Homology
more
  • Human Ortholog
    CACNG4, calcium voltage-gated channel auxiliary subunit gamma 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CACNG4, calcium voltage-gated channel auxiliary subunit gamma 4
  • Links
    NCBI Gene ID: 27092
    UniProt: Q9UBN1

  • Chr Location
    17q24.2; chr17:66964707-67033400 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 3 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are viable, fertile and phenotypically normal with no ataxic gait or absence seizures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    48
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    943
  • Tissues
    124
  • cDNA Data
    6
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020723 Ensembl Gene Model | MGI Sequence Detail 62201 C57BL/6J ±  kb
transcript ENSMUST00000021066 Ensembl | MGI Sequence Detail 3500 Not Applicable  
polypeptide ENSMUSP00000021066 Ensembl | MGI Sequence Detail 327 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000004953 voltage-dependent calcium channel gamma-4 subunit
    (term hierarchy)
  • InterPro Domains
    IPR004031 PMP-22/EMP/MP20/Claudin
    IPR005423 Voltage-dependent calcium channel, gamma-4 subunit
    IPR051072 Voltage-dependent calcium channel gamma subunit
    IPR008368 Voltage-dependent calcium channel, gamma subunit
  • GlyGen
    Q9JJV4 2 sites
Molecular
Reagents
less
  • All nucleic 11
    Genomic 1
    cDNA 7
    Primer pair 3

    Microarray probesets 2
Other
Accession IDs
less
MGI:2144142, MGI:2144541
References
more
  • Summaries
    All 46
    Developmental Gene Expression 5
    Gene Ontology 16
    Phenotypes 9
  • Earliest
    J:61749 Burgess DL, et al., Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication. Genome Res. 1999 Dec;9(12):1204-13
  • Latest
    J:278108 Luan C, et al., The calcium channel subunit gamma-4 is regulated by MafA and necessary for pancreatic beta-cell specification. Commun Biol. 2019;2:106
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory