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Cacng4 Gene Detail
Summary
  • Symbol
    Cacng4
  • Name
    calcium channel, voltage-dependent, gamma subunit 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859167
    NCBI Gene: 54377
  • Gene Overview
    MyGene.info: CACNG4
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:107734780-107794464 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 70.29 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    365 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859167
protein coding gene Chr11:107732357-107794557 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019323
protein coding gene Chr11:111154083-111218928 (-)
A/J MGP_AJ_G0019291
protein coding gene Chr11:106386079-106448619 (-)
AKR/J MGP_AKRJ_G0019260
protein coding gene Chr11:109565611-109631398 (-)
BALB/cJ MGP_BALBcJ_G0019265
protein coding gene Chr11:106805046-106871944 (-)
C3H/HeJ MGP_C3HHeJ_G0019074
protein coding gene Chr11:109878472-109943846 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019715
protein coding gene Chr11:114582939-114647789 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017339
protein coding gene Chr11:103647309-103708568 (-)
CAST/EiJ MGP_CASTEiJ_G0018627
protein coding gene Chr11:110979784-111045429 (-)
CBA/J MGP_CBAJ_G0019043
protein coding gene Chr11:119316403-119380821 (-)
DBA/2J MGP_DBA2J_G0019155
protein coding gene Chr11:105862294-105929939 (-)
FVB/NJ MGP_FVBNJ_G0019146
protein coding gene Chr11:105369842-105431919 (-)
LP/J MGP_LPJ_G0019225
protein coding gene Chr11:111597548-111666076 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019176
protein coding gene Chr11:118531072-118597206 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019752
protein coding gene Chr11:110116850-110189292 (-)
PWK/PhJ MGP_PWKPhJ_G0018392
protein coding gene Chr11:107008976-107071951 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018183
protein coding gene Chr11:109883608-109945636 (-)
WSB/EiJ MGP_WSBEiJ_G0018678
protein coding gene Chr11:110066219-110131495 (-)



Homology
more
  • Human Ortholog
    CACNG4, calcium voltage-gated channel auxiliary subunit gamma 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CACNG4, calcium voltage-gated channel auxiliary subunit gamma 4
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 27092
    neXtProt AC: NX_Q9UBN1
    UniProt: Q9UBN1

  • Chr Location
    17q24.2; chr17:66964864-67033402 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 3 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice are viable, fertile and phenotypically normal with no ataxic gait or absence seizures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 54377 NCBI Gene Model | MGI Sequence Detail 59685 C57BL/6J ±  kb
transcript NM_019431 RefSeq | MGI Sequence Detail 1397 C57BL/6  
polypeptide Q9JJV4 UniProt | EBI | MGI Sequence Detail 327 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000004953 voltage-dependent calcium channel gamma-4 subunit
  • InterPro Domains
    IPR004031 PMP-22/EMP/MP20/Claudin superfamily
    IPR005423 Voltage-dependent calcium channel, gamma-4 subunit
    IPR008368 Voltage-dependent calcium channel, gamma subunit
Molecular
Reagents
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  • All nucleic 11
    Genomic 1
    cDNA 7
    Primer pair 3

    Microarray probesets 2
Other
Accession IDs
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MGI:2144142, MGI:2144541
References
more
  • Summaries
    All 37
    Developmental Gene Expression 5
    Gene Ontology 11
    Phenotypes 6
  • Earliest
    J:61749 Burgess DL, et al., Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication. Genome Res. 1999 Dec;9(12):1204-13
  • Latest
    J:188364 Schwenk J, et al., High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes. Neuron. 2012 May 24;74(4):621-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory