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Pabpn1
Gene Detail
Symbol

Name
ID
Pabpn1
poly(A) binding protein, nuclear 1
MGI:1859158
Synonyms
Pabp3, poly(A) binding protein II
Feature Type
protein coding gene
Genetic Map
Chromosome 14
27.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:54892500-54898169 bp, + strand
From VEGA annotation of GRCm38

  5670 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3412  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

HCOP human homology predictions: PABPN1
Gene Tree: Pabpn1

Human
homologs
PABPN1, poly(A) binding protein, nuclear 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8106
neXtProt AC: NX_Q86U42

Human Synonyms: OPMD, PAB2, PABII, PABP2, PABP-2

Human Chr (Location): 14q11.2; chr14:23320188-23326185 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PABPN1

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(1) Transgenic(2)
Incidental mutations (data from CvDC )
Mutations Annotated to Human Diseases (2)   
Interactions
Pabpn1 interacts with 181 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process mRNA polyadenylation, mRNA processing, ...
Component cytoplasm, nuclear inclusion body, ...
Function nucleic acid binding, nucleotide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (66)    Tissues (52)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 64
RT-PCR 2
cDNA source data(171)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pabpn1 ; ZFIN pabpn1    NEW 
Molecular
reagents
All nucleic(172) cDNA(171) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000037620 (Evidence)
Ensembl Gene Model ENSMUSG00000022194 (Evidence)
Entrez Gene 54196 (Evidence)
UniGene 7723
DFCI TC1576661
DoTS DT.40160526, DT.101400674, DT.101400669, DT.94358789
NIA Mouse Gene Index U015637
Consensus CDS Project CCDS27104.1
International Mouse Phenotyping Consortium Status Pabpn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037620 VEGA Gene Model | MGI Sequence Detail 5670 C57BL/6J ±  kb
transcript OTTMUST00000081723 VEGA | MGI Sequence Detail 1775 Not Applicable 
polypeptide OTTMUSP00000054340 VEGA | MGI Sequence Detail 319 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(4) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(64 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
Protein Ontology PR:000012210 polyadenylate-binding protein 2
References
(Earliest) J:44882 Lee YJ, et al., Genomic structure and expression of murine poly(A) binding protein II gene. Biochim Biophys Acta. 1998 Jan 7;1395(1):40-6
(Latest) J:207412 Raz V, et al., A Novel Feed-Forward Loop between ARIH2 E3-Ligase and PABPN1 Regulates Aging-Associated Muscle Degeneration. Am J Pathol. 2014 Apr;184(4):1119-31
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory