Pabpn1
Gene Detail

Symbol Name ID

Pabpn1 poly(A) binding protein, nuclear 1 MGI:1859158

Synonyms

Pabp3, poly(A) binding protein II

Feature Type

protein coding gene

Genetic Map

Chromosome 14

27.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr14:54892500-54898169 bp, + strand From VEGA annotation of GRCm38   5670 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3412  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 zebrafish

Gene Tree: Pabpn1

Human homologs

Human Homolog		PABPN1, poly(A) binding protein, nuclear 1
NCBI Gene ID		8106
neXtProt AC		NX_Q86U42
Human Synonyms		OPMD, PAB2, PABII, PABP2, PABP-2
Human Chr (Location)		14q11.2; chr14:23789397-23795394 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PABPN1

Alleles and phenotypes

All alleles(1) : Targeted(1)

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	mRNA polyadenylation, mRNA processing, ...
Component	cytoplasm, nucleus, ...
Function	nucleic acid binding, nucleotide binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (66)    Tissues (44)    Images (16)
Theiler Stages: 19, 21, 23, 28

Assay Type	Results
RNA in situ	64
RT-PCR	2

cDNA source data(169)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(170) cDNA(169) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000037620 (Evidence)
Ensembl Gene Model	ENSMUSG00000022194 (Evidence)
Entrez Gene	54196 (Evidence)
UniGene	7723
DFCI	TC1576661
DoTS	DT.101400669, DT.101400674, DT.40160526, DT.94358789
NIA Mouse Gene Index	U015637
Consensus CDS Project	CCDS27104.1
International Mouse Knockout Project Status	Pabpn1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037620	VEGA Gene Model | MGI Sequence Detail	5670	C57BL/6J
transcript	OTTMUST00000081723	VEGA | MGI Sequence Detail	1775	Not Applicable
polypeptide	OTTMUSP00000054340	VEGA | MGI Sequence Detail	319	Not Applicable

All sequences(64) RefSeq(2) UniProt(7)

Polymorphisms

RFLP(1) : SNPs(18 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012677	Nucleotide-binding, alpha-beta plait
InterPro	IPR000504	RNA recognition motif domain
Protein Ontology	PR:000012210	polyadenylate-binding protein 2

References

(Earliest) J:44882 Lee YJ, et al., Genomic structure and expression of murine poly(A) binding protein II gene. Biochim Biophys Acta. 1998 Jan 7;1395(1):40-6
(Latest) J:178541 Mankodi A, et al., Progressive myopathy in an inducible mouse model of oculopharyngeal muscular dystrophy. Neurobiol Dis. 2012 Jan;45(1):539-46
All references(38)