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Pla2g6 Gene Detail
Summary
  • Symbol
    Pla2g6
  • Name
    phospholipase A2, group VI
  • Synonyms
    iPLA2, iPLA2beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859152
    NCBI Gene: 53357
Location & Maps
more
  • Sequence Map
    Chr15:79286228-79328390 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42163 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PLA2G6, phospholipase A2 group VI
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLA2G6, phospholipase A2 group VI
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CaI-PLA2, GVI, INAD1, iPLA2, iPLA2beta, IPLA2-VIA, NBIA2, NBIA2A, NBIA2B, PARK14, PLA2, PNPLA9
  • Links
    NCBI Gene ID: 8398
    neXtProt AC: NX_O60733

  • Chr Location
    22q13.1; chr22:38111495-38192109 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2635
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PLA2G6
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Pla2g6 mouse models; 3 with human PLA2G6 associations

Human Disease Mouse Models
       Neurodegeneration with Brain Iron Accumulation 2A; NBIA2A   OMIM: 256600 View 4 models
       Neurodegeneration with Brain Iron Accumulation 2B; NBIA2B   OMIM: 610217
Parkinson Disease 14, Autosomal Recessive; PARK14   OMIM: 612953
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    42 phenotypes from 5 alleles in 5 genetic backgrounds
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    46
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    35
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    6
  • Genomic Mutations
    3 involving Pla2g6
  • Incidental Mutations
Homozygous null mice display impaired male fertility and asthenozoospermia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037241 VEGA Gene Model | MGI Sequence Detail 42163 C57BL/6J ±  kb
transcript OTTMUST00000096168 VEGA | MGI Sequence Detail 3318 Not Applicable  
polypeptide OTTMUSP00000053698 VEGA | MGI Sequence Detail 807 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    190 from dbSNP Build 137
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000012811 85/88 kDa calcium-independent phospholipase A2
  • EC
  • InterPro Domains
    IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
    IPR002110 Ankyrin repeat
    IPR020683 Ankyrin repeat-containing domain
    IPR002641 Patatin/Phospholipase A2-related
Molecular
Reagents
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  • All nucleic 14
    cDNA 13
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:2146260
References
more
  • Summaries
    All 66
    Developmental Gene Expression 2
    Diseases 5
    Gene Ontology 5
    Phenotypes 53
  • Earliest
    J:44049 Balsinde J, et al., Antisense inhibition of group VI Ca2+-independent phospholipase A2 blocks phospholipid fatty acid remodeling in murine P388D1 macrophages. J Biol Chem. 1997 Nov 14;272(46):29317-21
  • Latest
    J:226333 Rauckhorst AJ, et al., The iPLA(2)gamma is identified as the membrane potential sensitive phospholipase in liver mitochondria. FEBS Lett. 2015 Aug 19;589(18):2367-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory