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Pla2g6 Gene Detail
Summary
  • Symbol
    Pla2g6
  • Name
    phospholipase A2, group VI
  • Synonyms
    iPLA2, iPLA2beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859152
    NCBI Gene: 53357
  • Gene Overview
    MyGene.info: PLA2G6
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:79286228-79328390 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 37.70 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    186 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859152
protein coding gene Chr15:79286228-79328390 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022071
protein coding gene Chr15:79542970-79586658 (-)
A/J MGP_AJ_G0022032
protein coding gene Chr15:76804530-76846241 (-)
AKR/J MGP_AKRJ_G0022007
protein coding gene Chr15:78940943-78990242 (-)
BALB/cJ MGP_BALBcJ_G0022038
protein coding gene Chr15:76791976-76837185 (-)
C3H/HeJ MGP_C3HHeJ_G0021809
protein coding gene Chr15:78931986-78981112 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022481
protein coding gene Chr15:82682606-82735395 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020011
protein coding gene Chr15:73284542-73327132 (-)
CAST/EiJ MGP_CASTEiJ_G0021330
protein coding gene Chr15:79633424-79683875 (-)
CBA/J MGP_CBAJ_G0021774
protein coding gene Chr15:85240117-85295839 (-)
DBA/2J MGP_DBA2J_G0021903
protein coding gene Chr15:76281495-76329786 (-)
FVB/NJ MGP_FVBNJ_G0021881
protein coding gene Chr15:75315069-75359852 (-)
LP/J MGP_LPJ_G0021971
protein coding gene Chr15:79735719-79780378 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021901
protein coding gene Chr15:90372949-90421901 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022495
protein coding gene Chr15:78957937-79005674 (-)
PWK/PhJ MGP_PWKPhJ_G0021072
protein coding gene Chr15:76292338-76338209 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020909
protein coding gene Chr15:78769064-78815257 (-)
WSB/EiJ MGP_WSBEiJ_G0021382
protein coding gene Chr15:79344116-79389190 (-)



Homology
more
  • Human Ortholog
    PLA2G6, phospholipase A2 group VI
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLA2G6, phospholipase A2 group VI
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CaI-PLA2, GVI, INAD1, iPLA2, iPLA2beta, IPLA2-VIA, NBIA2, NBIA2A, NBIA2B, PARK14, PLA2, PNPLA9
  • Links
    NCBI Gene ID: 8398
    neXtProt AC: NX_O60733
    UniProt: O60733

  • Chr Location
    22q13.1; chr22:38111495-38192099 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2635
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PLA2G6
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Pla2g6 mouse models; 3 with human PLA2G6 associations

Human Disease Mouse Models
      
IDs
View 4 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 5 alleles in 5 genetic backgrounds
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display impaired male fertility and asthenozoospermia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53357 NCBI Gene Model | MGI Sequence Detail 42163 C57BL/6J ±  kb
    transcript NM_001199023 RefSeq | MGI Sequence Detail 3725 C57BL/6  
    polypeptide P97819 UniProt | EBI | MGI Sequence Detail 807 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2146260
    References
    more
    • Summaries
      All 104
      Developmental Gene Expression 2
      Diseases 5
      Gene Ontology 6
      Phenotypes 63
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:238208 Chew WS, et al., Role of prefrontal cortical calcium-independent phospholipase A2 in antinociceptive effect of the norepinephrine reuptake inhibitor antidepresssant maprotiline. Neuroscience. 2017 Jan 6;340:91-100

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/27/2018
    MGI 6.13
    The Jackson Laboratory