Pla2g6
Gene Detail

Symbol Name ID

Pla2g6 phospholipase A2, group VI MGI:1859152

Synonyms

iPLA2, iPLA2beta

Feature Type

protein coding gene

Genetic Map

Chromosome 15

37.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr15:79286228-79328390 bp, - strand From VEGA annotation of GRCm38   42163 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2635  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Pla2g6

Human homologs

Human Homolog		PLA2G6, phospholipase A2, group VI (cytosolic, calcium-independent)
NCBI Gene ID		8398
neXtProt AC		NX_O60733
Human Synonyms		CaI-PLA2, GVI, INAD1, iPLA2, iPLA2beta, IPLA2-VIA, NBIA2, NBIA2A, NBIA2B, PARK14, PLA2, PNPLA9
Human Chr (Location)		22q13.1; chr22:38507502-38577836 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human PLA2G6

Alleles and phenotypes

All alleles(42) : Targeted(5) Gene trapped(35) Spontaneous(1) Chemically induced(1)
 

Homozygous null mice display impaired male fertility and asthenozoospermia.

 
Human Diseases Modeled Using Mouse Pla2g6 (1)    Alleles Annotated to Human Diseases(4)   

Gene Ontology (GO) classifications

All GO classifications: (30 annotations)

Process	cardiolipin biosynthetic process, chemotaxis, ...
Component	centrosome, cytoplasm, ...
Function	ATP-dependent protein binding, calcium-independent phospholipase A2 activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (98)    Tissues (98)   
Theiler Stages: 15, 17, 22

Assay Type	Results
RNA in situ	98

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) cDNA(13) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000037241 (Evidence)
Ensembl Gene Model	ENSMUSG00000042632 (Evidence)
Entrez Gene	53357 (Evidence)
NIA Mouse Gene Index	U036403
EC	3.1.1.4
Consensus CDS Project	CCDS27637.1, CCDS56991.1
International Mouse Knockout Project Status	Pla2g6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037241	VEGA Gene Model | MGI Sequence Detail	42163	C57BL/6J
transcript	OTTMUST00000096168	VEGA | MGI Sequence Detail	3318	Not Applicable
polypeptide	OTTMUSP00000053698	VEGA | MGI Sequence Detail	807	Not Applicable

All sequences(82) RefSeq(8) UniProt(7)

Polymorphisms

SNPs(129 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
InterPro	IPR002641	Patatin/Phospholipase A2-related
Protein Ontology	PR:000012811	85 kDa calcium-independent phospholipase A2

References

(Earliest) J:44049 Balsinde J, et al., Antisense inhibition of group VI Ca2+-independent phospholipase A2 blocks phospholipid fatty acid remodeling in murine P388D1 macrophages. J Biol Chem. 1997 Nov 14;272(46):29317-21
(Latest) J:188859 Liu S, et al., Smooth muscle-specific expression of calcium-independent phospholipase A2beta (iPLA2beta) participates in the initiation and early progression of vascular inflammation and neointima formation. J Biol Chem. 2012 Jul 13;287(29):24739-53
All references(65)

Other accession IDs

MGI:2146260