About   Help   FAQ
Pla2g6 Gene Detail
Summary
  • Symbol
    Pla2g6
  • Name
    phospholipase A2, group VI
  • Synonyms
    iPLA2, iPLA2beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859152
    NCBI Gene: 53357
  • Gene Overview
    MyGene.info: PLA2G6
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:79286228-79328390 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42163 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 37.70 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PLA2G6, phospholipase A2 group VI
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLA2G6, phospholipase A2 group VI
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CaI-PLA2, GVI, INAD1, iPLA2, iPLA2beta, IPLA2-VIA, NBIA2, NBIA2A, NBIA2B, PARK14, PLA2, PNPLA9
  • Links
    NCBI Gene ID: 8398
    neXtProt AC: NX_O60733
    UniProt: O60733

  • Chr Location
    22q13.1; chr22:38111495-38192099 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2635
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PLA2G6
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Pla2g6 mouse models; 3 with human PLA2G6 associations

Human Disease Mouse Models
      
IDs
View 4 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 5 alleles in 5 genetic backgrounds
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display impaired male fertility and asthenozoospermia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000037241 VEGA Gene Model | MGI Sequence Detail 42163 C57BL/6J ±  kb
    transcript OTTMUST00000096168 VEGA | MGI Sequence Detail 3318 Not Applicable  
    polypeptide OTTMUSP00000053698 VEGA | MGI Sequence Detail 807 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      186 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2146260
    References
    more
    • Summaries
      All 104
      Developmental Gene Expression 2
      Diseases 5
      Gene Ontology 6
      Phenotypes 62
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:238208 Chew WS, et al., Role of prefrontal cortical calcium-independent phospholipase A2 in antinociceptive effect of the norepinephrine reuptake inhibitor antidepresssant maprotiline. Neuroscience. 2017 Jan 6;340:91-100

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory