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Pla2g6
Gene Detail
Symbol

Name
ID
Pla2g6
phospholipase A2, group VI
MGI:1859152
Synonyms
iPLA2, iPLA2beta
Feature Type
protein coding gene
Genetic Map
Chromosome 15
37.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:79286228-79328390 bp, - strand
From VEGA annotation of GRCm38

  42163 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2635  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PLA2G6
Gene Tree: Pla2g6

Human
homologs
PLA2G6, phospholipase A2, group VI (cytosolic, calcium-independent)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8398
neXtProt AC: NX_O60733

Human Synonyms: CaI-PLA2, GVI, INAD1, iPLA2, iPLA2beta, IPLA2-VIA, NBIA2, NBIA2A, NBIA2B, PARK14, PLA2, PNPLA9

Human Chr (Location): 22q13.1; chr22:38111495-38192109 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human PLA2G6

Mutations,
alleles, and
phenotypes
All mutations/alleles(44) : Chemically induced (ENU)(1) Gene trapped(35) Radiation induced(1) Spontaneous(1) Targeted(6)
Genomic Mutations involving Pla2g6 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display impaired male fertility and asthenozoospermia.
 
Human Diseases Modeled in Mice Using Pla2g6 (1)    Mutations Annotated to Human Diseases (4)    Phenotype Images(2)
Interactions
Pla2g6 interacts with 110 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process antibacterial humoral response, cardiolipin biosynthetic process, ...
Component cytoplasm, cytosol, ...
Function ATP-dependent protein binding, calcium-independent phospholipase A2 activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (98)    Tissues (98)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 98
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pla2g6    NEW 
Molecular
reagents
All nucleic(14) cDNA(13) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000037241 (Evidence)
Ensembl Gene Model ENSMUSG00000042632 (Evidence)
Entrez Gene 53357 (Evidence)
NIA Mouse Gene Index U036403
EC 3.1.1.4
Consensus CDS Project CCDS27637.1, CCDS56991.1
International Mouse Phenotyping Consortium Status Pla2g6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037241 VEGA Gene Model | MGI Sequence Detail 42163 C57BL/6J ±  kb
transcript OTTMUST00000096168 VEGA | MGI Sequence Detail 3318 Not Applicable 
polypeptide OTTMUSP00000053698 VEGA | MGI Sequence Detail 807 Not Applicable 

For the selected sequences
All sequences(105) RefSeq(27) UniProt(7)
Polymorphisms
SNPs within 2kb(190 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR002641 Patatin/Phospholipase A2-related
Protein Ontology PR:000012811 85/88 kDa calcium-independent phospholipase A2
References
(Earliest) J:44049 Balsinde J, et al., Antisense inhibition of group VI Ca2+-independent phospholipase A2 blocks phospholipid fatty acid remodeling in murine P388D1 macrophages. J Biol Chem. 1997 Nov 14;272(46):29317-21
(Latest) J:218128 Lei X, et al., Evidence of contribution of iPLA2beta-mediated events during islet beta-cell apoptosis due to proinflammatory cytokines suggests a role for iPLA2beta in T1D development. Endocrinology. 2014 Sep;155(9):3352-64
All references(66)
Disease annotation references (4)
Other
accession IDs
MGI:2146260

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory