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Akap7 Gene Detail
Summary
  • Symbol
    Akap7
  • Name
    A kinase anchor protein 7
  • Synonyms
    AKAP15, Akap18
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859150
    NCBI Gene: 432442
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:25044988-25175115 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 12.26 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4635 from dbSNP Build 142
  • Strain Annotations
    25
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859150
 protein coding gene Chr10:25044988-25183768 (-)
129S1/SvImJ ENSMUSGG00200054601
 protein coding gene Chr10:21882128-21913196 (-)
129S1/SvImJ ENSMUSG00200008697
 protein coding gene Chr10:21925360-22010201 (-)
A/J ENSMUSGG00195055284
 protein coding gene Chr10:22188136-22219199 (-)
A/J ENSMUSG00195013439
 protein coding gene Chr10:22231351-22316195 (-)
AKR/J ENSMUSGG00220054549
 protein coding gene Chr10:21868514-21899566 (-)
AKR/J ENSMUSG00220010833
 protein coding gene Chr10:21911724-21996572 (-)
BALB/cJ ENSMUSGG00180055007
 protein coding gene Chr10:22311381-22342439 (-)
BALB/cJ ENSMUSG00180016151
 protein coding gene Chr10:22354591-22439428 (-)
C3H/HeJ ENSMUSG00175024052
 protein coding gene Chr10:22028449-22113289 (-)
C3H/HeJ ENSMUSGG00175055090
 protein coding gene Chr10:21985238-22016291 (-)
C57BL/6NJ ENSMUSG00215011312
 protein coding gene Chr10:21876866-21961653 (-)
C57BL/6NJ ENSMUSGG00215055517
 protein coding gene Chr10:21833651-21864720 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015193
 protein coding gene Chr10:21176180-21308426 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210023221
 protein coding gene Chr10:21993237-22078000 (-)
CBA/J ENSMUSGG00210054580
 protein coding gene Chr10:21950023-21981095 (-)
DBA/2J ENSMUSGG00185057749
 protein coding gene Chr10:22119951-22151023 (-)
DBA/2J ENSMUSG00185006788
 protein coding gene Chr10:22163166-22247942 (-)
FVB/NJ ENSMUSG00205009286
 protein coding gene Chr10:22169291-22254113 (-)
FVB/NJ ENSMUSGG00205054554
 protein coding gene Chr10:22126082-22157132 (-)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055728
 protein coding gene Chr10:23916695-23947761 (-)
LP/J ENSMUSG00230009113
 protein coding gene Chr10:23959925-24044759 (-)
NOD/ShiLtJ ENSMUSGG00190054850
 protein coding gene Chr10:22259050-22290340 (-)
NOD/ShiLtJ ENSMUSG00190015128
 protein coding gene Chr10:22302494-22387410 (-)
NZO/HlLtJ ENSMUSGG00225055415
 protein coding gene Chr10:28167631-28198689 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    AKAP7, A-kinase anchoring protein 7
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKAP7, A-kinase anchoring protein 7
  • Synonyms
    AKAP15, AKAP18
  • Links
    NCBI Gene ID: 9465
    UniProt: O43687, Q9P0M2

  • Chr Location
    6q23.2; chr6:131125627-131283535 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and fertile and show normal cardiomyocyte response to adrenergic stimulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    627
  • Tissues
    20
  • cDNA Data
    9
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 432442 NCBI Gene Model | MGI Sequence Detail 130128 C57BL/6J ±  kb
    transcript NR_166567 RefSeq | MGI Sequence Detail 4143 C57BL/6  
    polypeptide Q7TN79 UniProt | EBI | MGI Sequence Detail 314 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000004556 A-kinase anchor protein 7
      (term hierarchy)
    • InterPro Domains
      IPR052641 A-kinase anchor protein 7 isoform gamma
      IPR019510 A-kinase anchor protein 7-like, phosphoesterase domain
      IPR019511 A-kinase anchor protein 7, RI-RII subunit-binding domain
      IPR009097 Cyclic phosphodiesterase
    • GlyGen
      Q7TN79 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9
      Antibodies 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2143664, MGI:2143901
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 18
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:369188 Park T, et al., Long AKAP18 isoforms anchor ubiquitin specific proteinases and coordinate calcium reuptake at the sarcoplasmic reticulum. J Biol Chem. 2025 May 29;301(7):110317
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory