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Akap7 Gene Detail
Summary
  • Symbol
    Akap7
  • Name
    A kinase (PRKA) anchor protein 7
  • Synonyms
    AKAP15, Akap18
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859150
    NCBI Gene: 432442
  • Gene Overview
    MyGene.info: AKAP7
Location & Maps
more
  • Sequence Map
    Chr10:25169090-25307870 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      138781 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 12.26 cM, cytoband A3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    AKAP7, A-kinase anchoring protein 7
  • Vertebrate Orthologs
    8
  • Human Ortholog
    AKAP7, A-kinase anchoring protein 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AKAP15, AKAP18
  • Links
    NCBI Gene ID: 9465
    neXtProt AC: NX_O43687, NX_Q9P0M2
    UniProt: O43687, Q9P0M2

  • Chr Location
    6q23.2; chr6:131125698-131283535 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotype references
Mice homozygous for a knock-out allele are viable and fertile and show normal cardiomyocyte response to adrenergic stimulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042011 VEGA Gene Model | MGI Sequence Detail 138781 C57BL/6J ±  kb
transcript OTTMUST00000110097 VEGA | MGI Sequence Detail 2092 Not Applicable  
polypeptide OTTMUSP00000061348 VEGA | MGI Sequence Detail 314 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    996 from dbSNP Build 142
Protein
Information
less
  • UniProt
    7 Sequences
  • InterPro Domains
    IPR019511 A-kinase anchor protein 7, RI-RII subunit-binding domain
    IPR009097 Cyclic phosphodiesterase
    IPR019510 Protein kinase A anchor protein, nuclear localisation signal domain
Molecular
Reagents
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  • All nucleic 8
    cDNA 8

    Microarray probesets 6
Other
Accession IDs
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MGI:2143664, MGI:2143901
References
more
  • Summaries
    All 40
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:239454 Jones BW, et al., Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination. Elife. 2016 Dec 02;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory