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Batf Gene Detail
Summary
  • Symbol
    Batf
  • Name
    basic leucine zipper transcription factor, ATF-like
  • Synonyms
    B-ATF, SFA-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859147
    NCBI Gene: 53314
  • Gene Overview
    MyGene.info: BATF
Location & Maps
more
  • Sequence Map
    Chr12:85686669-85709087 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22419 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 39.78 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    BATF, basic leucine zipper ATF-like transcription factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BATF, basic leucine zipper ATF-like transcription factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    B-ATF, BATF1, SFA2, SFA-2
  • Links
    NCBI Gene ID: 10538
    neXtProt AC: NX_Q16520

  • Chr Location
    14q24.3; chr14:75522441-75546992 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4666
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: BATF
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Targeted
    5
  • Genomic Mutations
    1 involving Batf
  • Incidental Mutations
Homozygote null mice are defective in generation of Th17 T cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016692 VEGA Gene Model | MGI Sequence Detail 22419 C57BL/6J ±  kb
transcript OTTMUST00000040432 VEGA | MGI Sequence Detail 955 Not Applicable  
polypeptide OTTMUSP00000018061 VEGA | MGI Sequence Detail 125 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    140 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000004654 basic leucine zipper transcriptional factor ATF-like
  • InterPro Domains
    IPR000837 AP-1 transcription factor
    IPR004827 Basic-leucine zipper domain
    IPR029820 Basic leucine zipper transcriptional factor ATF-like
Molecular
Reagents
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  • All nucleic 16
    Genomic 1
    cDNA 15

    Microarray probesets 3
References
more
  • Summaries
    All 46
    Developmental Gene Expression 3
    Gene Ontology 10
    Phenotypes 18
  • Earliest
    J:62034 Williams KL, et al., Characterization of murine BATF: a negative regulator of activator protein-1 activity in the thymus. Eur J Immunol. 2001 May;31(5):1620-7
  • Latest
    J:223848 Vasanthakumar A, et al., The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells. Nat Immunol. 2015 Mar;16(3):276-85

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory