Batf MGI Mouse Gene Detail - MGI:1859147 - basic leucine zipper transcription factor, ATF-like

Symbol

Batf
Name

basic leucine zipper transcription factor, ATF-like
Synonyms

B-ATF, SFA-2

Feature Type

protein coding gene
IDs

MGI:1859147
NCBI Gene: 53314
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr12:85733494-85755861 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 39.78 cM
Mapping Data

2 experiments

SNPs within 2kb

686 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859147	protein coding gene	Chr12:85733443-85755861 (+)
129S1/SvImJ	ENSMUSG00200049693	protein coding gene	Chr12:77748681-77771095 (+)
A/J	ENSMUSG00195028496	protein coding gene	Chr12:80368315-80390740 (+)
AKR/J	ENSMUSG00220048574	protein coding gene	Chr12:78164244-78186671 (+)
BALB/cJ	ENSMUSG00180019404	protein coding gene	Chr12:79406038-79428460 (+)
C3H/HeJ	ENSMUSG00175037216	protein coding gene	Chr12:82499104-82521525 (+)
C57BL/6NJ	ENSMUSG00215043432	protein coding gene	Chr12:78712496-78734919 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017969	protein coding gene	Chr12:80077253-80099074 (+)
CAST/EiJ	ENSTCUG00005028561	protein coding gene	Chr12:78674527-78696472 (+)
CBA/J	ENSMUSG00210045418	protein coding gene	Chr12:78912306-78934724 (+)
DBA/2J	ENSMUSG00185002479	protein coding gene	Chr12:80769561-80791981 (+)
FVB/NJ	ENSMUSG00205020603	protein coding gene	Chr12:78581098-78603520 (+)
JF1/MsJ	ENSUMUG00000046026	protein coding gene	Chr12:84755287-84777340 (+)
LP/J	ENSMUSG00230042634	protein coding gene	Chr12:87831736-87854154 (+)
NOD/ShiLtJ	ENSMUSG00190037386	protein coding gene	Chr12:77969308-77991727 (+)
NZO/HlLtJ	ENSMUSG00225048799	protein coding gene	Chr12:89868870-89891290 (+)
PWK/PhJ	ENSLUMG00010025117	protein coding gene	Chr12:78775282-78797295 (+)
SPRET/EiJ	ENSMSPG00010017093	protein coding gene	Chr12:80592258-80614112 (+)
WSB/EiJ	ENSIUOG00005042289	protein coding gene	Chr12:78622092-78644132 (+)

Human Ortholog

BATF, basic leucine zipper ATF-like transcription factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BATF, basic leucine zipper ATF-like transcription factor
Synonyms

B-ATF, BATF1, SFA-2, SFA2
Links

HGNC:958

NCBI Gene ID: 10538

UniProt: Q16520
Chr Location

14q24.3; chr14:75522455-75546993 (+) GRCh38

MGI Vertebrate Homology

Batf stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BATF
Gene Tree

Batf

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Phenotype Summary

17 phenotypes from 2 alleles in 2 genetic backgrounds
1 images
67 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

3
Targeted

8
Genomic Mutations

1 involving Batf
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygote null mice are defective in generation of Th17 T cells.

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All GO Annotations

39
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

139
cDNA Data

15
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA BATF

ZFIN batf

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All Sequences

31
RefSeq

2
UniProt

1
CCDS

CCDS26061.1

Ensembl

ENSMUSG00000034266 (Evidence)
NCBI Gene

53314

			Length	Strain/Species	Flank
genomic	53314	NCBI Gene Model \| MGI Sequence Detail	22368	C57BL/6J	± kb
transcript	NM_016767	RefSeq \| MGI Sequence Detail	904	C57BL/6
polypeptide	O35284	UniProt \| EBI \| MGI Sequence Detail	125	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000004654 basic leucine zipper transcriptional factor ATF-like

(term hierarchy)
InterPro Domains

IPR000837 AP-1 transcription factor

IPR004827 Basic-leucine zipper domain

IPR046347 Basic-leucine zipper domain superfamily

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All nucleic 17

Genomic 2

cDNA 15

Microarray probesets 3

Summaries

All 129

Developmental Gene Expression 3

Gene Ontology 14

Phenotypes 67
Earliest

J:62034 Williams KL, et al., Characterization of murine BATF: a negative regulator of activator protein-1 activity in the thymus. Eur J Immunol. 2001 May;31(5):1620-7
Latest

J:391244 Murakami R, et al., Foxp3 and BATF cooperatively direct cis-regulatory programs and gene expression for effector Treg cell differentiation. Immunity. 2026 Mar 30;

TSS for Batf:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114425	Chr12:85733422-85733476 (+)	-45 bp
Tssr114426	Chr12:85733487-85733502 (+)	1 bp
Tssr114427	Chr12:85752754-85752757 (+)	19,262 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24