Cnot4
Gene Detail

Symbol Name ID

Cnot4 CCR4-NOT transcription complex, subunit 4 MGI:1859026

Synonyms

Not4, Not4h, Not4hp

Feature Type

protein coding gene

Genetic Map

Chromosome 6

15.20 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr6:35022066-35133737 bp, - strand From Ensembl annotation of GRCm38   111672 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:40870  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Cnot4

Human homologs

Human Homolog		CNOT4, CCR4-NOT transcription complex, subunit 4
NCBI Gene ID		4850
neXtProt AC		NX_O95628
Human Synonyms		CLONE243, NOT4, NOT4H
Human Chr (Location)		7q22-qter; chr7:135046547-135194875 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(51) : Targeted(2) Gene trapped(49)

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	protein autoubiquitination, regulation of transcription, DNA-dependent, ...
Component	CCR4-NOT complex, cytoplasm, ...
Function	ligase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (145)    Tissues (138)    Images (16)
Theiler Stages: 17, 18, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	143
RT-PCR	2

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) cDNA(20) Primer pair(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000038784 (Evidence)
Entrez Gene	53621 (Evidence)
DFCI	TC1576929, TC1586748, TC1596829, TC1598437, TC1602479, TC1612639, TC1653181
DoTS	DT.101308611, DT.101322992, DT.489261, DT.523738, DT.94188124
NIA Mouse Gene Index	U027158, U281364
EC	6.3.2.-
PDB	2CPI
Consensus CDS Project	CCDS19999.1, CCDS51746.1, CCDS51747.1
International Mouse Knockout Project Status	Cnot4

Sequences

Length	Strain/Species
genomic	ENSMUSG00000038784	Ensembl Gene Model | MGI Sequence Detail	111672	C57BL/6J
transcript	ENSMUST00000114993	Ensembl | MGI Sequence Detail	3526	Not Applicable
polypeptide	ENSMUSP00000110645	Ensembl | MGI Sequence Detail	710	Not Applicable

All sequences(58) RefSeq(10) UniProt(5)

Polymorphisms

SNPs(202 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012677	Nucleotide-binding, alpha-beta plait
InterPro	IPR000504	RNA recognition motif domain
InterPro	IPR000571	Zinc finger, CCCH-type
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
InterPro	IPR001841	Zinc finger, RING-type
Protein Ontology	PR:000005652	CCR4-NOT transcription complex subunit 4

References

(Earliest) J:69146 Hwang SY, et al., Expression of genes involved in mammalian meiosis during the transition from egg to embryo. Mol Reprod Dev. 2001 Jun;59(2):144-58
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(41)