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Atf7ip Gene Detail
Summary
  • Symbol
    Atf7ip
  • Name
    activating transcription factor 7 interacting protein
  • Synonyms
    2610204M12Rik, AM, ATFa-associated Modulator, Mcaf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858965
    NCBI Gene: 54343
  • Gene Overview
    MyGene.info: ATF7IP
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:136518807-136610850 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 66.59 cM, cytoband G1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    823 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858965
protein coding gene Chr6:136506167-136610862 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031422
protein coding gene Chr6:140934493-141042965 (+)
A/J MGP_AJ_G0031398
protein coding gene Chr6:135369797-135460654 (+)
AKR/J MGP_AKRJ_G0031325
protein coding gene Chr6:139476054-139580477 (+)
BALB/cJ MGP_BALBcJ_G0031405
protein coding gene Chr6:135222547-135330377 (+)
C3H/HeJ MGP_C3HHeJ_G0031126
protein coding gene Chr6:139526516-139622831 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031865
protein coding gene Chr6:144813777-144917932 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028996
protein coding gene Chr6:134529628-134621233 (+)
CAST/EiJ MGP_CASTEiJ_G0030495
protein coding gene Chr6:139014733-139114410 (+)
CBA/J MGP_CBAJ_G0031085
protein coding gene Chr6:150175732-150284886 (+)
DBA/2J MGP_DBA2J_G0031243
protein coding gene Chr6:134220153-134323910 (+)
FVB/NJ MGP_FVBNJ_G0031193
protein coding gene Chr6:133130138-133233768 (+)
LP/J MGP_LPJ_G0031327
protein coding gene Chr6:141064912-141171780 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031233
protein coding gene Chr6:154067371-154187183 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031897
protein coding gene Chr6:139258920-139351847 (+)
PWK/PhJ MGP_PWKPhJ_G0030221
protein coding gene Chr6:132732505-132839008 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030044
protein coding gene Chr6:137488028-137598776 (+)
WSB/EiJ MGP_WSBEiJ_G0030586
protein coding gene Chr6:139865827-139973023 (+)



Homology
more
  • Human Ortholog
    ATF7IP, activating transcription factor 7 interacting protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ATF7IP, activating transcription factor 7 interacting protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AM, ATF-IP, MCAF, MCAF1, p621
  • Links
    NCBI Gene ID: 55729
    neXtProt AC: NX_Q6VMQ6
    UniProt: Q6VMQ6

  • Chr Location
    12p13.1; chr12:14365632-14502935 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 54343 NCBI Gene Model | MGI Sequence Detail 92044 C57BL/6J ±  kb
transcript NM_019426 RefSeq | MGI Sequence Detail 4543 C57BL/6  
polypeptide Q7TT18 UniProt | EBI | MGI Sequence Detail 1306 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000004405 activating transcription factor 7-interacting protein 1
  • InterPro Domains
    IPR026085 Activating transcription factor 7-interacting protein
    IPR031870 ATF7-interacting protein , protein binding domain
    IPR003961 Fibronectin type III
    IPR036116 Fibronectin type III superfamily
    IPR013783 Immunoglobulin-like fold
Molecular
Reagents
less
  • All nucleic 24
    cDNA 24

    Microarray probesets 7
Other
Accession IDs
less
MGI:1919738
References
more
  • Summaries
    All 31
    Developmental Gene Expression 4
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:61657 De Graeve F, et al., A murine ATFa-associated factor with transcriptional repressing activity. Oncogene. 2000 Mar 30;19(14):1807-19
  • Latest
    J:209441 Waterfield M, et al., The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance. Nat Immunol. 2014 Mar;15(3):258-65

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory