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Gnpnat1 Gene Detail
Summary
  • Symbol
    Gnpnat1
  • Name
    glucosamine-phosphate N-acetyltransferase 1
  • Synonyms
    EMeg32
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858963
    NCBI Gene: 54342
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:45613897-45626972 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 22.92 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    27 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858963
 protein coding gene Chr14:45613791-45642370 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0021155
 protein coding gene Chr14:37835870-37865784 (-)
AKR/J MGP_AKRJ_G0021133
 protein coding gene Chr14:39325219-39337168 (-)
BALB/cJ MGP_BALBcJ_G0021159
 protein coding gene Chr14:37892567-37905521 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0021593
 protein coding gene Chr14:40696111-40708761 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019152
 protein coding gene Chr14:37274305-37287573 (-)
CAST/EiJ MGP_CASTEiJ_G0020467
 protein coding gene Chr14:36254929-36267376 (-)
CBA/J MGP_CBAJ_G0020908
 protein coding gene Chr14:42008499-42020542 (-)
DBA/2J MGP_DBA2J_G0021031
 protein coding gene Chr14:37762849-37777101 (-)
FVB/NJ MGP_FVBNJ_G0021016
 protein coding gene Chr14:37522170-37534950 (-)
LP/J MGP_LPJ_G0021101
 protein coding gene Chr14:39287389-39300318 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021041
 protein coding gene Chr14:41393441-41406256 (-)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0020216
 protein coding gene Chr14:34625768-34638271 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020040
 protein coding gene Chr14:35034553-35046820 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    GNPNAT1, glucosamine-phosphate N-acetyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNPNAT1, glucosamine-phosphate N-acetyltransferase 1
  • Synonyms
    GNA1, GNPNAT, Gpnat1, RHZDAN
  • Links
    NCBI Gene ID: 64841
    neXtProt AC: NX_Q96EK6
    UniProt: Q96EK6

  • Chr Location
    14q22.1; chr14:52775193-52791668 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutation of this gene result in homozygous lethality by E7.5 with various developmental defects observed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    830
  • Tissues
    108
  • cDNA Data
    28
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54342 NCBI Gene Model | MGI Sequence Detail 13076 C57BL/6J ±  kb
    transcript NM_001417540 RefSeq | MGI Sequence Detail 2218 C57BL/6  
    polypeptide Q9JK38 UniProt | EBI | MGI Sequence Detail 184 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 28
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2145728, MGI:2147320
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:61844 Inohara N, et al., Mtd, a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL. J Biol Chem. 1998 Apr 10;273(15):8705-10
    • Latest
      J:283457 Uijtdewilligen PJE, et al., Dynamic Expression of Genes Involved in Proteoglycan/Glycosaminoglycan Metabolism during Skin Development. Biomed Res Int. 2018;2018:9873471
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory