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Gnpnat1 Gene Detail
Summary
  • Symbol
    Gnpnat1
  • Name
    glucosamine-phosphate N-acetyltransferase 1
  • Synonyms
    EMeg32
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858963
    NCBI Gene: 54342
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:45376421-45388956 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 22.92 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    27 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858963
protein coding gene Chr14:45376334-45404913 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0021155
protein coding gene Chr14:37835870-37865784 (-)
AKR/J MGP_AKRJ_G0021133
protein coding gene Chr14:39325219-39337168 (-)
BALB/cJ MGP_BALBcJ_G0021159
protein coding gene Chr14:37892567-37905521 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0021593
protein coding gene Chr14:40696111-40708761 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019152
protein coding gene Chr14:37274305-37287573 (-)
CAST/EiJ MGP_CASTEiJ_G0020467
protein coding gene Chr14:36254929-36267376 (-)
CBA/J MGP_CBAJ_G0020908
protein coding gene Chr14:42008499-42020542 (-)
DBA/2J MGP_DBA2J_G0021031
protein coding gene Chr14:37762849-37777101 (-)
FVB/NJ MGP_FVBNJ_G0021016
protein coding gene Chr14:37522170-37534950 (-)
LP/J MGP_LPJ_G0021101
protein coding gene Chr14:39287389-39300318 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021041
protein coding gene Chr14:41393441-41406256 (-)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0020216
protein coding gene Chr14:34625768-34638271 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020040
protein coding gene Chr14:35034553-35046820 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    GNPNAT1, glucosamine-phosphate N-acetyltransferase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GNPNAT1, glucosamine-phosphate N-acetyltransferase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GNA1, GNPNAT, Gpnat1
  • Links
    NCBI Gene ID: 64841
    neXtProt AC: NX_Q96EK6
    UniProt: Q96EK6

  • Chr Location
    14q22.1; chr14:52775193-52791668 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutation of this gene result in homozygous lethality by E7.5 with various developmental defects observed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54342 NCBI Gene Model | MGI Sequence Detail 12536 C57BL/6J ±  kb
    transcript NM_019425 RefSeq | MGI Sequence Detail 2536 C57BL/6  
    polypeptide Q9JK38 UniProt | EBI | MGI Sequence Detail 184 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 28
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2145728, MGI:2147320
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:61844 Inohara N, et al., Mtd, a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL. J Biol Chem. 1998 Apr 10;273(15):8705-10
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory