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Prc1 Gene Detail
Summary
  • Symbol
    Prc1
  • Name
    protein regulator of cytokinesis 1
  • Synonyms
    D7Ertd348e, MGC:6745
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858961
    NCBI Gene: 233406
  • Gene Overview
    MyGene.info: PRC1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:80294451-80316259 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 45.62 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    323 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858961
protein coding gene Chr7:80294450-80316259 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032410
protein coding gene Chr7:82264000-82286531 (+)
A/J MGP_AJ_G0032389
protein coding gene Chr7:80337667-80359399 (+)
AKR/J MGP_AKRJ_G0032325
protein coding gene Chr7:82075543-82097283 (+)
BALB/cJ MGP_BALBcJ_G0032401
protein coding gene Chr7:80014436-80036197 (+)
C3H/HeJ MGP_C3HHeJ_G0032114
protein coding gene Chr7:82725410-82749401 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032893
protein coding gene Chr7:85484262-85506043 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029901
protein coding gene Chr7:82857872-82880286 (+)
CAST/EiJ MGP_CASTEiJ_G0031442
protein coding gene Chr7:73609972-73811403 (+)
CBA/J MGP_CBAJ_G0032080
protein coding gene Chr7:88335086-88356742 (+)
DBA/2J MGP_DBA2J_G0032235
protein coding gene Chr7:78896443-78918102 (+)
FVB/NJ MGP_FVBNJ_G0032190
protein coding gene Chr7:78809208-78831101 (+)
LP/J MGP_LPJ_G0032316
protein coding gene Chr7:83502194-83525294 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032227
protein coding gene Chr7:88491689-88515732 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032911
protein coding gene Chr7:81509396-81533572 (+)
PWK/PhJ MGP_PWKPhJ_G0031162
protein coding gene Chr7:72081389-72104102 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031003
protein coding gene Chr7:68516482-68542186 (+)
WSB/EiJ MGP_WSBEiJ_G0031560
protein coding gene Chr7:81863901-81891701 (+)



Homology
more
  • Human Ortholog
    PRC1, protein regulator of cytokinesis 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRC1, protein regulator of cytokinesis 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ASE1
  • Links
    NCBI Gene ID: 9055
    neXtProt AC: NX_O43663
    UniProt: O43663

  • Chr Location
    15q26.1; chr15:90966038-90994651 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37868
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PRC1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 233406 NCBI Gene Model | MGI Sequence Detail 21809 C57BL/6J ±  kb
    transcript NM_145150 RefSeq | MGI Sequence Detail 3049 C57BL/6  
    polypeptide Q99K43 UniProt | EBI | MGI Sequence Detail 603 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • InterPro Domains
      IPR007145 Microtubule-associated protein, MAP65/Ase1/PRC1
      IPR032921 Protein regulator of cytokinesis 1
    Molecular
    Reagents
    less
    • All nucleic 206
      cDNA 203
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1289307
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 9
      Gene Ontology 5
      Phenotypes 20
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:242063 Lau MS, et al., Mutation of a nucleosome compaction region disrupts Polycomb-mediated axial patterning. Science. 2017 Mar 10;355(6329):1081-1084

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory