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Prc1 Gene Detail
Summary
  • Symbol
    Prc1
  • Name
    protein regulator of cytokinesis 1
  • Synonyms
    D7Ertd348e, MGC:6745
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858961
    NCBI Gene: 233406
  • Gene Overview
    MyGene.info: PRC1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:80294450-80316259 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21810 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 45.62 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PRC1, protein regulator of cytokinesis 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRC1, protein regulator of cytokinesis 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ASE1
  • Links
    NCBI Gene ID: 9055
    neXtProt AC: NX_O43663
    UniProt: O43663

  • Chr Location
    15q26.1; chr15:90966038-90994651 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37868
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PRC1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000037307 VEGA Gene Model | MGI Sequence Detail 21810 C57BL/6J ±  kb
    transcript OTTMUST00000096306 VEGA | MGI Sequence Detail 3008 Not Applicable  
    polypeptide OTTMUSP00000053790 VEGA | MGI Sequence Detail 620 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      323 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • InterPro Domains
      IPR007145 Microtubule-associated protein, MAP65/Ase1/PRC1
      IPR032921 Protein regulator of cytokinesis 1
    Molecular
    Reagents
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    • All nucleic 204
      cDNA 202
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1289307
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 9
      Gene Ontology 5
      Phenotypes 20
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:242063 Lau MS, et al., Mutation of a nucleosome compaction region disrupts Polycomb-mediated axial patterning. Science. 2017 Mar 10;355(6329):1081-1084

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory