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Prc1 Gene Detail
Summary
  • Symbol
    Prc1
  • Name
    protein regulator of cytokinesis 1
  • Synonyms
    D7Ertd348e, MGC:6745
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858961
    NCBI Gene: 233406
  • Gene Overview
    MyGene.info: PRC1
Location & Maps
more
  • Sequence Map
    Chr7:80294450-80316259 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21810 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 45.62 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PRC1, protein regulator of cytokinesis 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRC1, protein regulator of cytokinesis 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ASE1
  • Links
    NCBI Gene ID: 9055
    neXtProt AC: NX_O43663

  • Chr Location
    15q26.1; chr15:90966038-90994651 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 37868
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PRC1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    26
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    19
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Prc1
  • Incidental Mutations
Mice homozygous for an ENU-induced allele exhibit embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037307 VEGA Gene Model | MGI Sequence Detail 21810 C57BL/6J ±  kb
transcript OTTMUST00000096306 VEGA | MGI Sequence Detail 3008 Not Applicable  
polypeptide OTTMUSP00000053790 VEGA | MGI Sequence Detail 620 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    323 from dbSNP Build 142
Protein
Information
less
  • UniProt
    11 Sequences
  • InterPro Domains
    IPR007145 Microtubule-associated protein, MAP65/Ase1/PRC1
    IPR032921 Protein regulator of cytokinesis 1
Molecular
Reagents
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  • All nucleic 204
    cDNA 202
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:1289307
References
more
  • Summaries
    All 43
    Developmental Gene Expression 8
    Gene Ontology 4
    Phenotypes 20
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:217538 Lui JH, et al., Radial glia require PDGFD-PDGFRbeta signalling in human but not mouse neocortex. Nature. 2014 Nov 13;515(7526):264-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory