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Elovl2
Gene Detail
 Symbol
Name
ID
Elovl2
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2
MGI:1858960
Synonyms Ssc2
Feature Type protein coding gene
Genetic Map
Chromosome 13
20.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:41182495-41220405 bp, - strand
From VEGA annotation of GRCm38

  37911 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23042  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Elovl2

Human
homologs
Human Homolog ELOVL2, ELOVL fatty acid elongase 2
NCBI Gene ID 54898
neXtProt AC  NX_Q9NXB9
Human Synonyms  SSC2
Human Chr (Location)  6p24.2; chr6:10980759-11044391 (-)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice heterozygous for a knock-out allele exhibit reduced male fertility. Mice homozygous for a knock-out allele exhibit male infertility associated with arrested spermatogenesis.
 
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process fatty acid biosynthetic process, fatty acid elongation, polyunsaturated fatty acid, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function fatty acid elongase activity, transferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (210)    Tissues (123)    Images (38)
Theiler Stages: 19, 22, 23, 28
Assay TypeResults
RNA in situ 208
RT-PCR 2
cDNA source data(44)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(45) cDNA(44) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000029813 (Evidence)
Ensembl Gene ModelENSMUSG00000021364 (Evidence)
Entrez Gene54326 (Evidence)
UniGene2567
DFCITC1577439, TC1714794
DoTSDT.489418, DT.97408703
NIA Mouse Gene IndexU034713
EC2.3.1.199
Consensus CDS ProjectCCDS36639.1
International Mouse Knockout Project StatusElovl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029813 VEGA Gene Model | MGI Sequence Detail 37911 C57BL/6J ±  kb
transcript OTTMUST00000074002 VEGA | MGI Sequence Detail 3726 Not Applicable 
polypeptide OTTMUSP00000038380 VEGA | MGI Sequence Detail 292 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(375 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002076 GNS1/SUR4 membrane protein
Protein Ontology PR:000007037 elongation of very long chain fatty acids protein 2
References (Earliest) J:61900 Tvrdik P, et al., Role of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids. J Cell Biol. 2000 May 1;149(3):707-18
(Latest) J:208771 Pauter AM, et al., Elovl2 ablation demonstrates that systemic DHA is endogenously produced and is essential for lipid homeostasis in mice. J Lipid Res. 2014 Apr;55(4):718-28
All references(39)
Other
accession IDs
MGI:2145206

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory