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Elovl2 Gene Detail
Summary
  • Symbol
    Elovl2
  • Name
    elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2
  • Synonyms
    Ssc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858960
    NCBI Gene: 54326
Location & Maps
more
  • Sequence Map
    Chr13:41182495-41220405 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      37911 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ELOVL2, ELOVL fatty acid elongase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ELOVL2, ELOVL fatty acid elongase 2
    Orthology source: HomoloGene
  • Synonyms
    SSC2
  • Links
    NCBI Gene ID: 54898
    neXtProt AC: NX_Q9NXB9

  • Chr Location
    6p24.2; chr6:10980759-11044391 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Elovl2
  • Incidental Mutations
Mice heterozygous for a knock-out allele exhibit reduced male fertility. Mice homozygous for a knock-out allele exhibit male infertility associated with arrested spermatogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029813 VEGA Gene Model | MGI Sequence Detail 37911 C57BL/6J ±  kb
transcript OTTMUST00000074002 VEGA | MGI Sequence Detail 3726 Not Applicable  
polypeptide OTTMUSP00000038380 VEGA | MGI Sequence Detail 292 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    375 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 45
    cDNA 44
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2145206
References
more
  • Summaries
    All 38
    Developmental Gene Expression 10
    Gene Ontology 7
    Phenotypes 7
  • Earliest
    J:61900 Tvrdik P, et al., Role of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids. J Cell Biol. 2000 May 1;149(3):707-18
  • Latest
    J:216600 Lau CG, et al., Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil. Mol Reprod Dev. 2014 Nov;81(11):994-1008

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory