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Elovl1 Gene Detail
Summary
  • Symbol
    Elovl1
  • Name
    elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
  • Synonyms
    Ssc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858959
    NCBI Gene: 54325
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:118428093-118432953 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 54.61 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    17 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858959
protein coding gene Chr4:118428084-118432953 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028667
protein coding gene Chr4:119485050-119489557 (+)
A/J MGP_AJ_G0028628
protein coding gene Chr4:114849955-114854529 (+)
AKR/J MGP_AKRJ_G0028578
protein coding gene Chr4:117354398-117358488 (+)
BALB/cJ MGP_BALBcJ_G0028649
protein coding gene Chr4:115490953-115495478 (+)
C3H/HeJ MGP_C3HHeJ_G0028363
protein coding gene Chr4:118933659-118938177 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029090
protein coding gene Chr4:124049538-124054129 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026374
protein coding gene Chr4:108869068-108873959 (+)
CAST/EiJ MGP_CASTEiJ_G0027797
protein coding gene Chr4:116192710-116197303 (+)
CBA/J MGP_CBAJ_G0028330
protein coding gene Chr4:127457389-127461915 (+)
DBA/2J MGP_DBA2J_G0028478
protein coding gene Chr4:115460913-115465498 (+)
FVB/NJ MGP_FVBNJ_G0028446
protein coding gene Chr4:113979658-113984602 (+)
LP/J MGP_LPJ_G0028580
protein coding gene Chr4:119665256-119669845 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028473
protein coding gene Chr4:132337757-132342262 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029127
protein coding gene Chr4:118518992-118523577 (+)
PWK/PhJ MGP_PWKPhJ_G0027523
protein coding gene Chr4:112293070-112297710 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027346
protein coding gene Chr4:114819594-114824181 (+)
WSB/EiJ MGP_WSBEiJ_G0027876
protein coding gene Chr4:118415196-118419703 (+)



Homology
more
  • Human Ortholog
    ELOVL1, ELOVL fatty acid elongase 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ELOVL1, ELOVL fatty acid elongase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CGI-88, Ssc1
  • Links
    NCBI Gene ID: 64834
    neXtProt AC: NX_Q9BW60
    UniProt: Q9BW60

  • Chr Location
    1p34.2; chr1:43363397-43368074 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 41322
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ELOVL1
  • Gene Tree
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice hoozygous for a targeted allele exhibit complete neonatal lethality, abnormal skin morphology, impaired skin barrier function, decreased weight and impaired formation of very long chain fatty acids.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000006390 Ensembl Gene Model | MGI Sequence Detail 4861 C57BL/6J ±  kb
    transcript ENSMUST00000006557 Ensembl | MGI Sequence Detail 1811 Not Applicable  
    polypeptide ENSMUSP00000006557 Ensembl | MGI Sequence Detail 279 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 16
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2140119, MGI:2140640
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:170151 LORCH J, Note on the cytological localization of alkaline phosphatase. Q J Microsc Sci. 1947 Jun;88(Pt 2):159-61
    • Latest
      J:261184 Honda Y, et al., Decreased Skin Barrier Lipid Acylceramide and Differentiation-Dependent Gene Expression in Ichthyosis Gene Nipal4-Knockout Mice. J Invest Dermatol. 2018 Apr;138(4):741-749

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory