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Sept1 Gene Detail
Summary
  • Symbol
    Sept1
  • Name
    septin 1
  • Synonyms
    Diff6, PNUTL3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858916
    NCBI Gene: 54204
  • Gene Overview
    MyGene.info: SEPT1
Location & Maps
more
  • Sequence Map
    Chr7:127214447-127233130 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18684 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SEPT1, septin 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SEPT1, septin 1
    Orthology source: HomoloGene
  • Synonyms
    DIFF6, LARP, PNUTL3, SEP1
  • Links
    NCBI Gene ID: 1731
    neXtProt AC: NX_Q8WYJ6

  • Chr Location
    16p11.1; chr16:30378133-30382850 (-)  GRCh38.p2

Human Diseases
less
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    64
  • Gene trapped
    60
  • Targeted
    4
  • Genomic Mutations
    2 involving Sept1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022181 VEGA Gene Model | MGI Sequence Detail 18684 C57BL/6J ±  kb
transcript OTTMUST00000052670 VEGA | MGI Sequence Detail 1486 Not Applicable  
polypeptide OTTMUSP00000025010 VEGA | MGI Sequence Detail 366 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    91 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000014648 septin-1
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR016491 Septin
    IPR030379 Septin-type guanine nucleotide-binding (G) domain
Molecular
Reagents
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  • All nucleic 22
    cDNA 22

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Diseases 5
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:25671 Nottenburg C, et al., Lymphocyte HEV adhesion variants differ in the expression of multiple gene sequences. Gene. 1990 Nov 15;95(2):279-84
  • Latest
    J:186260 Yoshida A, et al., Localization of septin proteins in the mouse cochlea. Hear Res. 2012 Jul;289(1-2):40-51

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory