About   Help   FAQ
Sept1 Gene Detail
Summary
  • Symbol
    Sept1
  • Name
    septin 1
  • Synonyms
    Diff6, PNUTL3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858916
    NCBI Gene: 54204
  • Gene Overview
    MyGene.info: SEPT1
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127214442-127232987 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.39 cM, cytoband F4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    91 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858916
protein coding gene Chr7:127214442-127233130 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033026
protein coding gene Chr7:131548725-131568654 (-)
A/J MGP_AJ_G0033009
protein coding gene Chr7:128046110-128064716 (-)
AKR/J MGP_AKRJ_G0032941
protein coding gene Chr7:131296081-131317936 (-)
BALB/cJ MGP_BALBcJ_G0033014
protein coding gene Chr7:127707599-127726515 (-)
C3H/HeJ MGP_C3HHeJ_G0032724
protein coding gene Chr7:131232422-131252521 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033520
protein coding gene Chr7:136658059-136677773 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030492
protein coding gene Chr7:129259665-129277535 (-)
CAST/EiJ MGP_CASTEiJ_G0032053
protein coding gene Chr7:123027851-123047165 (-)
CBA/J MGP_CBAJ_G0032697
protein coding gene Chr7:141258145-141279479 (-)
DBA/2J MGP_DBA2J_G0032849
protein coding gene Chr7:126017611-126036561 (-)
FVB/NJ MGP_FVBNJ_G0032802
protein coding gene Chr7:125870971-125889535 (-)
LP/J MGP_LPJ_G0032943
protein coding gene Chr7:133013003-133031744 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032834
protein coding gene Chr7:142403851-142425406 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033539
protein coding gene Chr7:130309952-130333020 (-)
PWK/PhJ MGP_PWKPhJ_G0031760
protein coding gene Chr7:119026215-119045717 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031606
protein coding gene Chr7:117147868-117167887 (-)
WSB/EiJ MGP_WSBEiJ_G0032165
protein coding gene Chr7:131284914-131305878 (-)



Homology
more
  • Human Ortholog
    SEPT1, septin 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SEPT1, septin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DIFF6, LARP, PNUTL3, SEP1
  • Links
    NCBI Gene ID: 1731
    neXtProt AC: NX_Q8WYJ6
    UniProt: Q8WYJ6

  • Chr Location
    16p11.2; chr16:30378133-30382850 (-)  GRCh38.p7

Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 54204 NCBI Gene Model | MGI Sequence Detail 18546 C57BL/6J ±  kb
transcript NM_017461 RefSeq | MGI Sequence Detail 1466 C57BL/6  
polypeptide P42209 UniProt | EBI | MGI Sequence Detail 366 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    cDNA 23

    Microarray probesets 3
References
more
  • Summaries
    All 45
    Developmental Gene Expression 2
    Diseases 2
    Gene Ontology 6
    Phenotypes 18
  • Earliest
    J:25671 Nottenburg C, et al., Lymphocyte HEV adhesion variants differ in the expression of multiple gene sequences. Gene. 1990 Nov 15;95(2):279-84
  • Latest
    J:263550 Wang W, et al., Chemogenetic Activation of Prefrontal Cortex Rescues Synaptic and Behavioral Deficits in a Mouse Model of 16p11.2 Deletion Syndrome. J Neurosci. 2018 Jun 27;38(26):5939-5948

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory