Fut8
Gene Detail

Symbol Name ID

Fut8 fucosyltransferase 8 MGI:1858901

Synonyms

alpha (1,6) fucosyltransferase

Feature Type

protein coding gene

Genetic Map

Chromosome 12

35.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr12:77238104-77475996 bp, + strand From NCBI annotation of GRCm38   237893 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9650  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: alpha-(1,6)-fucosyltransferase, eukaryotic type
Gene Tree: Fut8

Human homologs

Human Homolog		FUT8, fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
NCBI Gene ID		2530
neXtProt AC		NX_Q9BYC5
Human Chr (Location)		14q24.3; chr14:65877310-66210839 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(3) Gene trapped(5)
 

Homozygous null mutation of this gene results in partial postnatal lethality, growth retardation, and progressive emphysema-like changes that include enlarged alveoli, increased lung capacity and compliance, and alveolar cell apoptosis. Postnatal survival is sensitive to genetic background.

 
Human Diseases Modeled Using Mouse Fut8 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	cell migration, fucosylation, ...
Component	Golgi apparatus, Golgi cisterna membrane, ...
Function	alpha-(1->6)-fucosyltransferase activity, glycoprotein 6-alpha-L-fucosyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (12)    Tissues (3)   
Theiler Stages: 21, 25, 28

Assay Type	Results
RT-PCR	12

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000021065 (Evidence)
Entrez Gene	53618 (Evidence)
DFCI	TC1572721, TC1660509, TC1662477
DoTS	DT.101704596, DT.110916023, DT.110916040, DT.530176, DT.55259091, DT.94325491, DT.94368597
NIA Mouse Gene Index	U014126
EC	2.4.1.68
Consensus CDS Project	CCDS25999.1
International Mouse Knockout Project Status	Fut8

Sequences

Length	Strain/Species
genomic	53618	NCBI Gene Model | MGI Sequence Detail	237893	C57BL/6J
transcript	NR_045554	RefSeq | MGI Sequence Detail	3342	Not Specified
polypeptide	Q9WTS2	UniProt | EBI | MGI Sequence Detail	575	Not Applicable

All sequences(52) RefSeq(9) UniProt(4)

Polymorphisms

SNPs(505 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015827	Alpha-(1,6)-fucosyltransferase, eukaryotic type
InterPro	IPR001452	Src homology-3 domain
Protein Ontology	PR:000007707	alpha-(1,6)-fucosyltransferase

Graphical View of Protein Domain Structure

References

(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:185966 Kamio K, et al., alpha1,6-Fucosyltransferase (Fut8) is implicated in vulnerability to elastase-induced emphysema in mice and a possible non-invasive predictive marker for disease progression and exacerbations in chronic obstructive pulmonary disease (COPD). Biochem Biophys Res Commun. 2012 Jul 20;424(1):112-7
All references(39)