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Fut8
Gene Detail
 Symbol
Name
ID
Fut8
fucosyltransferase 8
MGI:1858901
Synonyms alpha (1,6) fucosyltransferase
Feature Type protein coding gene
Genetic Map
Chromosome 12
35.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:77238104-77475996 bp, + strand
From NCBI annotation of GRCm38

  237893 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9650  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: alpha-(1,6)-fucosyltransferase, eukaryotic type
Gene Tree: Fut8

Human
homologs
Human Homolog FUT8, fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
NCBI Gene ID 2530
neXtProt AC  NX_Q9BYC5
Human Chr (Location)  14q24.3; chr14:65410592-65744121 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(5) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutation of this gene results in partial postnatal lethality, growth retardation, and progressive emphysema-like changes that include enlarged alveoli, increased lung capacity and compliance, and alveolar cell apoptosis. Postnatal survival is sensitive to genetic background.
 
Human Diseases Modeled Using Mouse Fut8 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Fut8 interacts with 230 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cell migration, fucosylation, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function alpha-(1->6)-fucosyltransferase activity, glycoprotein 6-alpha-L-fucosyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (12)    Tissues (4)   
Theiler Stages: 21, 25, 27, 28
Assay TypeResults
RT-PCR 12
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000021065 (Evidence)
Entrez Gene53618 (Evidence)
DFCITC1572721, TC1660509, TC1662477
DoTSDT.101704596, DT.110916023, DT.110916040, DT.530176, DT.55259091, DT.94325491, DT.94368597
NIA Mouse Gene IndexU014126
EC2.4.1.68
Consensus CDS ProjectCCDS25999.1
International Mouse Knockout Project StatusFut8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 53618 NCBI Gene Model | MGI Sequence Detail 237893 C57BL/6J ±  kb
transcript NR_045554 RefSeq | MGI Sequence Detail 3342 Not Specified 
polypeptide Q9WTS2 UniProt | EBI | MGI Sequence Detail 575 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(9) UniProt(4)
Polymorphisms SNPs within 2kb(553 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015827 Alpha-(1,6)-fucosyltransferase, eukaryotic type
InterPro IPR027350 Glycosyltransferase family 23 (GT23) domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000007707 alpha-(1,6)-fucosyltransferase
Graphical View of Protein Domain Structure
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:203497 Sasaki H, et al., alpha-1,6-Fucosyltransferase (FUT8) inhibits hemoglobin production during differentiation of murine and K562 human erythroleukemia cells. J Biol Chem. 2013 Jun 7;288(23):16839-47
All references(40)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory