Kat6b
Gene Detail

Symbol Name ID

Kat6b K(lysine) acetyltransferase 6B MGI:1858746

Synonyms

B130044K16Rik, monocytic leukemia, Morf, Myst4, qkf, querkopf

Feature Type

protein coding gene

Genetic Map

Chromosome 14

11.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr14:21499785-21672478 bp, + strand From Ensembl annotation of GRCm38   172694 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:49310  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Kat6b

Human homologs

Human Homolog		KAT6B, K(lysine) acetyltransferase 6B
NCBI Gene ID		23522
neXtProt AC		NX_Q8WYB5
Human Synonyms		GTPTS, MORF, MOZ2, MYST4, qkf, querkopf, ZC2HC6B
Human Chr (Location)		10q22.2; chr10:76586171-76792380 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human KAT6B

Alleles and phenotypes

All alleles(79) : Gene trapped(79)
 

Reduced expression of this gene results in developmental defects of the skeleton and brain, particularly the cerebral cortex.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	chromatin modification, histone acetylation, ...
Component	chromosome, MOZ/MORF histone acetyltransferase complex, ...
Function	acetyltransferase activity, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (81)    Tissues (44)    Images (4)
Theiler Stages: 2, 3, 4, 5, 17, 18, 19, 21, 23, 28

Assay Type	Results
RNA in situ	30
RT-PCR	51

cDNA source data(123)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(125) cDNA(123) Primer pair(2)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000021767 (Evidence)
Entrez Gene	54169 (Evidence)
UniGene	248967
DFCI	TC1575109, TC1588777, TC1593447, TC1617155, TC1620857, TC1703381, TC1759300, TC1773225
DoTS	DT.101134843, DT.101401316, DT.101401318, DT.101737527, DT.101737530, DT.102557193, DT.487606, DT.91327092, DT.91362374
NIA Mouse Gene Index	U015372
EC	2.3.1.48
International Mouse Knockout Project Status	Kat6b

Sequences

Length	Strain/Species
genomic	ENSMUSG00000021767	Ensembl Gene Model | MGI Sequence Detail	172694	C57BL/6J
transcript	ENSMUST00000069648	Ensembl | MGI Sequence Detail	7649	Not Applicable
polypeptide	ENSMUSP00000066693	Ensembl | MGI Sequence Detail	1872	Not Applicable

All sequences(57) RefSeq(4) UniProt(6)

Polymorphisms

SNPs(875 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016181	Acyl-CoA N-acyltransferase
InterPro	IPR005818	Histone H1/H5
InterPro	IPR002717	MOZ/SAS-like protein
InterPro	IPR011991	Winged helix-turn-helix DNA-binding domain
InterPro	IPR011011	Zinc finger, FYVE/PHD-type
InterPro	IPR019787	Zinc finger, PHD-finger
InterPro	IPR001965	Zinc finger, PHD-type
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
Protein Ontology	PR:000010891	histone acetyltransferase MYST4

References

(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:191385 Clayton-Smith J, et al., Whole-exome-sequencing identifies mutations in histone acetyltransferase gene KAT6B in individuals with the Say-Barber-Biesecker variant of Ohdo syndrome. Am J Hum Genet. 2011 Nov 11;89(5):675-81
All references(46)

Other accession IDs

MGI:2145668, MGI:2443197