Kat6b
Gene Detail

Symbol

Name
ID

Kat6b
K(lysine) acetyltransferase 6B
MGI:1858746

Synonyms

B130044K16Rik, monocytic leukemia, Morf, Myst4, qkf, querkopf

Feature Type

protein coding gene

Genetic Map

Chromosome 14
11.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr14:21481434-21672478 bp, + strand From VEGA annotation of GRCm38   191045 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:136480  Vertebrate Homology Class
1 mouse; 1 rat

Gene Tree: Kat6b

Mutations,
alleles, and
phenotypes

All mutations/alleles(222) : Gene trapped(222)
Incidental mutations (data from APF )
 

Reduced expression of this gene results in developmental defects of the skeleton and brain, particularly the cerebral cortex.

 

Interactions

Kat6b interacts with 344 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (17 annotations)

Process	chromatin modification, histone acetylation, ...
Component	nucleosome, nucleus
Function	DNA binding, histone acetyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)

Data Summary: Results (74)    Tissues (40)    Images (4)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	30
RT-PCR	44

cDNA source data(123)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(125) cDNA(123) Primer pair(2)
Microarray probesets(5)

Other database
links

VEGA Gene Model	OTTMUSG00000043207 (Evidence)
Ensembl Gene Model	ENSMUSG00000021767 (Evidence)
Entrez Gene	54169 (Evidence)
UniGene	248967
DFCI	TC1588777, TC1575109, TC1620857, TC1617155, TC1593447, TC1703381, TC1773225, TC1759300
DoTS	DT.101134843, DT.101737530, DT.102557193, DT.487606, DT.101737527, DT.101401316, DT.101401318, DT.91327092, DT.91362374
NIA Mouse Gene Index	U015372
EC	2.3.1.48
Consensus CDS Project	CCDS59615.1
International Mouse Knockout Project Status	Kat6b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000043207	VEGA Gene Model | MGI Sequence Detail	191045	C57BL/6J
transcript	OTTMUST00000113320	VEGA | MGI Sequence Detail	7660	Not Applicable
polypeptide	OTTMUSP00000063398	VEGA | MGI Sequence Detail	1872	Not Applicable

All sequences(111) RefSeq(22) UniProt(13)

Polymorphisms

SNPs within 2kb(1037 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1039)

Protein-related
information

Resource	ID	Description
InterPro	IPR016181	Acyl-CoA N-acyltransferase
InterPro	IPR005818	Histone H1/H5
InterPro	IPR002717	MOZ/SAS-like protein
InterPro	IPR011991	Winged helix-turn-helix DNA-binding domain
InterPro	IPR011011	Zinc finger, FYVE/PHD-type
InterPro	IPR019787	Zinc finger, PHD-finger
InterPro	IPR001965	Zinc finger, PHD-type
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
Protein Ontology	PR:000010891	histone acetyltransferase KAT6B

References

(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:197289 Sheikh BN, et al., Querkopf is a key marker of self-renewal and multipotency of adult neural stem cells. J Cell Sci. 2012 Jan 15;125(Pt 2):295-309
All references(49)

Other
accession IDs

MGI:2145668, MGI:2443197