Kat6b MGI Mouse Gene Detail - MGI:1858746 - K(lysine) acetyltransferase 6B

Kat6b Gene Detail

Symbol

Kat6b
Name

K(lysine) acetyltransferase 6B
Synonyms

B130044K16Rik, monocytic leukemia, Morf, Myst4, qkf, querkopf

Feature Type

protein coding gene
IDs

MGI:1858746
NCBI Gene: 54169
Gene Overview

MyGene.info: KAT6B

Sequence Map

Chr14:21481434-21672478 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

191045 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 11.73 cM
Mapping Data

2 experiments

Human Ortholog

KAT6B, lysine acetyltransferase 6B

Vertebrate Orthologs

2

Human Ortholog

KAT6B, lysine acetyltransferase 6B
Orthology source: HGNC
Synonyms

GTPTS, MORF, MOZ2, MYST4, qkf, querkopf, ZC2HC6B
Links

HGNC:17582

NCBI Gene ID: 23522

neXtProt AC: NX_Q8WYB5
Chr Location

10q22.2; chr10:74824927-75032623 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 136480
1 mouse;1 rat
HCOP

human homology predictions: KAT6B
Gene Tree

Kat6b

Diseases

2 with human KAT6B associations

				Human Disease	Mouse Models
				Genitopatellar Syndrome; GTPTS OMIM: 606170
				Ohdo Syndrome, Sbbys Variant; SBBYSS OMIM: 603736

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

29 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

223
Chemically induced (ENU)

1
Gene trapped

222
Incidental Mutations

APF , CvDC

Reduced expression of this gene results in developmental defects of the skeleton and brain, particularly the cerebral cortex.

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All GO Annotations

17
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

74
Tissues

40
cDNA Data

123
Literature Summary

11

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

ZFIN kat6b

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Kat6b interacts with 343 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

87
RefSeq

22
UniProt

7
CCDS

CCDS59615.1
UniGene

248967

			Length	Strain/Species	Flank
genomic	OTTMUSG00000043207	VEGA Gene Model \| MGI Sequence Detail	191045	C57BL/6J	± kb
transcript	OTTMUST00000113320	VEGA \| MGI Sequence Detail	7660	Not Applicable
polypeptide	OTTMUSP00000063398	VEGA \| MGI Sequence Detail	1872	Not Applicable

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SNPs within 2kb

1028 from dbSNP Build 142

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UniProt

7 Sequences
Protein Ontology

PR:000010891 histone acetyltransferase KAT6B
EC

2.3.1.48
InterPro Domains

IPR016181 Acyl-CoA N-acyltransferase

IPR002717 Histone acetyltransferase domain, MYST-type

IPR005818 Linker histone H1/H5, domain H15

IPR011991 Winged helix-turn-helix DNA-binding domain

IPR011011 Zinc finger, FYVE/PHD-type

IPR019787 Zinc finger, PHD-finger

IPR001965 Zinc finger, PHD-type

IPR013083 Zinc finger, RING/FYVE/PHD-type

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All nucleic 125

cDNA 123

Primer pair 2

Microarray probesets 5

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MGI:2145668, MGI:2443197

Summaries

All 46

Developmental Gene Expression 11

Gene Ontology 4

Phenotypes 15
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
Latest

J:197289 Sheikh BN, et al., Querkopf is a key marker of self-renewal and multipotency of adult neural stem cells. J Cell Sci. 2012 Jan 15;125(Pt 2):295-309

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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