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Kat6b Gene Detail
Summary
  • Symbol
    Kat6b
  • Name
    K(lysine) acetyltransferase 6B
  • Synonyms
    B130044K16Rik, monocytic leukemia, Morf, Myst4, qkf, querkopf
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858746
    NCBI Gene: 54169
  • Gene Overview
    MyGene.info: KAT6B
Location & Maps
more
  • Sequence Map
    Chr14:21481434-21672478 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      191045 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 11.73 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    KAT6B, lysine acetyltransferase 6B
  • Vertebrate Orthologs
    2
  • Human Ortholog
    KAT6B, lysine acetyltransferase 6B
    Orthology source: HGNC
  • Synonyms
    GTPTS, MORF, MOZ2, MYST4, qkf, querkopf, ZC2HC6B
  • Links
    NCBI Gene ID: 23522
    neXtProt AC: NX_Q8WYB5

  • Chr Location
    10q22.2; chr10:74824927-75032623 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human KAT6B associations

Human Disease Mouse Models
       Genitopatellar Syndrome; GTPTS   OMIM: 606170
Ohdo Syndrome, Sbbys Variant; SBBYSS   OMIM: 603736
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    223
  • Chemically induced (ENU)
    1
  • Gene trapped
    222
  • Incidental Mutations
    APF , CvDC
Reduced expression of this gene results in developmental defects of the skeleton and brain, particularly the cerebral cortex.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043207 VEGA Gene Model | MGI Sequence Detail 191045 C57BL/6J ±  kb
transcript OTTMUST00000113320 VEGA | MGI Sequence Detail 7660 Not Applicable  
polypeptide OTTMUSP00000063398 VEGA | MGI Sequence Detail 1872 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1028 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 125
    cDNA 123
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
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MGI:2145668, MGI:2443197
References
more
  • Summaries
    All 46
    Developmental Gene Expression 11
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:197289 Sheikh BN, et al., Querkopf is a key marker of self-renewal and multipotency of adult neural stem cells. J Cell Sci. 2012 Jan 15;125(Pt 2):295-309

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory