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Rasa4 Gene Detail
Summary
  • Symbol
    Rasa4
  • Name
    RAS p21 protein activator 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858600
    NCBI Gene: 54153
  • Gene Overview
    MyGene.info: RASA4
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:136083916-136111860 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 75.76 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    135 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858600
protein coding gene Chr5:136083916-136111860 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030199
protein coding gene Chr5:140703852-140737027 (+)
A/J MGP_AJ_G0030167
protein coding gene Chr5:134648135-134677823 (+)
AKR/J MGP_AKRJ_G0030100
protein coding gene Chr5:139001120-139030721 (+)
BALB/cJ MGP_BALBcJ_G0030177
protein coding gene Chr5:136004007-136035594 (+)
C3H/HeJ MGP_C3HHeJ_G0029893
protein coding gene Chr5:139616516-139651124 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030630
protein coding gene Chr5:145937189-145966773 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027850
protein coding gene Chr5:128935120-128963173 (+)
CAST/EiJ MGP_CASTEiJ_G0029303
protein coding gene Chr5:139019315-139051016 (+)
CBA/J MGP_CBAJ_G0029863
protein coding gene Chr5:151632672-151677227 (+)
DBA/2J MGP_DBA2J_G0030014
protein coding gene Chr5:134550447-134578092 (+)
FVB/NJ MGP_FVBNJ_G0029969
protein coding gene Chr5:133703003-133732170 (+)
LP/J MGP_LPJ_G0030103
protein coding gene Chr5:141131014-141163458 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030001
protein coding gene Chr5:154614846-154646307 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030670
protein coding gene Chr5:138813014-138841784 (+)
PWK/PhJ MGP_PWKPhJ_G0029016
protein coding gene Chr5:133610536-133637116 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028852
protein coding gene Chr5:136365100-136396849 (+)
WSB/EiJ MGP_WSBEiJ_G0029376
protein coding gene Chr5:139537793-139570873 (+)



Homology
more
  • Human Ortholog
    RASA4, RAS p21 protein activator 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RASA4, RAS p21 protein activator 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAPRI, GAPL
  • Links
    NCBI Gene ID: 10156
    neXtProt AC: NX_O43374
    UniProt: O43374

  • Chr Location
    7q22.1; chr7:102579646-102616758 (-)  GRCh38.p7

  • Human Ortholog
    RASA4B, RAS p21 protein activator 4B
    Orthology source: HGNC
  • Links
    NCBI Gene ID: 100271927
    neXtProt AC: NX_C9J798
    UniProt: C9J798

  • Chr Location
    7q22.1; chr7:102483139-102517777 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display an increased sensitivity to bacterial infections which involves reduced phagocyte function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 54153 NCBI Gene Model | MGI Sequence Detail 27945 C57BL/6J ±  kb
transcript NM_133914 RefSeq | MGI Sequence Detail 2933 C57BL/6  
polypeptide Q6PFQ7 UniProt | EBI | MGI Sequence Detail 802 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 45
    cDNA 43
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2141155, MGI:2141261
References
more
  • Summaries
    All 28
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:62157 Thomas JW, et al., Comparative genome mapping in the sequence-based era: early experience with human chromosome 7. Genome Res. 2000 May;10(5):624-33
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory