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Egfl6 Gene Detail
Summary
  • Symbol
    Egfl6
  • Name
    EGF-like-domain, multiple 6
  • Synonyms
    Maeg
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858599
    NCBI Gene: 54156
Location & Maps
more
  • Sequence Map
    ChrX:166523007-166585720 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      62714 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 77.66 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    EGFL6, EGF like domain multiple 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EGFL6, EGF like domain multiple 6
    Orthology source: HomoloGene
  • Synonyms
    MAEG, W80
  • Links
    NCBI Gene ID: 25975
    neXtProt AC: NX_Q8IUX8

  • Chr Location
    Xp22; chrX:13569575-13633575 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 9166
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: EGFL6
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
  • All Mutations and Alleles
    19
  • Gene trapped
    14
  • Targeted
    5
Mice hemizygous for a targeted allele are apparently normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019543 VEGA Gene Model | MGI Sequence Detail 62714 C57BL/6J ±  kb
transcript OTTMUST00000046678 VEGA | MGI Sequence Detail 2704 Not Applicable  
polypeptide OTTMUSP00000021086 VEGA | MGI Sequence Detail 550 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    224 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000006930 epidermal growth factor-like protein 6
  • InterPro Domains
    IPR013320 Concanavalin A-like lectin/glucanase domain
    IPR018097 EGF-like calcium-binding, conserved site
    IPR001881 EGF-like calcium-binding domain
    IPR013032 EGF-like, conserved site
    IPR000742 EGF-like domain
    IPR000152 EGF-type aspartate/asparagine hydroxylation site
    IPR032930 Epidermal growth factor-like protein 6
    IPR023413 Green fluorescent protein-like
    IPR009030 Growth factor receptor cysteine-rich domain
    IPR000998 MAM domain
Molecular
Reagents
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  • All nucleic 10
    cDNA 8
    Primer pair 1
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 32
    Developmental Gene Expression 10
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:61762 Buchner G, et al., Identification of a new EGF-repeat-containing gene from human Xp22: a candidate for developmental disorders. Genomics. 2000 Apr 1;65(1):16-23
  • Latest
    J:208419 Basta JM, et al., Sall1 balances self-renewal and differentiation of renal progenitor cells. Development. 2014 Mar;141(5):1047-58

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory