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Rnase2b
Gene Detail
Symbol

Name
ID
Rnase2b
ribonuclease, RNase A family, 2B (liver, eosinophil-derived neurotoxin)
MGI:1858598
Synonyms
Ear5, mR5, murine ribonuclease 5
Feature Type
protein coding gene
Genetic Map
Chromosome 14
26.40 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:51162260-51163018 bp, + strand
From NCBI annotation of GRCm38

  759 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:121614  Vertebrate Homology Class
1 human; 2 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Protein SuperFamily: pyrimidine-specific ribonuclease/angiogenin
Gene Tree: Rnase2b

Human
homologs
Human Homolog RNASE2, ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
NCBI Gene ID 6036
neXtProt AC  NX_P10153
Human Synonyms  EDN, RAF3, RNS2
Human Chr (Location)  14q11.2; chr14:20955471-20956435 (+)  GRCh38
Interactions
Rnase2b interacts with 13 markers (Mir22, Mir34a, Mir194-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Component extracellular vesicular exosome
Function endonuclease activity, hydrolase activity, ...
External Resources: FuncBase
Expression
cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(4) cDNA(4)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000059606 (Evidence)
Entrez Gene54159 (Evidence)
UniGene377125
DFCITC1654026
DoTSDT.91349766
NIA Mouse Gene IndexU015583
Consensus CDS ProjectCCDS27039.1
International Mouse Knockout Project StatusRnase2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 54159 NCBI Gene Model | MGI Sequence Detail 759 C57BL/6J ±  kb
transcript NM_019398 RefSeq | MGI Sequence Detail 759 C57BL/6 
polypeptide O35292 UniProt | EBI | MGI Sequence Detail 155 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(64 from dbSNP Build 137)    SNPs within 2kb including multiple locations(68)
Protein-related
information
ResourceIDDescription
InterPro IPR001427 Ribonuclease A
InterPro IPR023411 Ribonuclease A, active site
InterPro IPR023412 Ribonuclease A-domain
Protein Ontology PR:000007283 eosinophil cationic-type ribonuclease 5
Graphical View of Protein Domain Structure
References
(Earliest) J:36253 Larson KA, et al., Two highly homologous ribonuclease genes expressed in mouse eosinophils identify a larger subgroup of the mammalian ribonuclease superfamily. Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12370-5
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(26)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory