Diap2
Gene Detail

Symbol Name ID

Diap2 diaphanous homolog 2 (Drosophila) MGI:1858500

Synonyms

Dia3, E430022I22Rik

Feature Type

protein coding gene

Genetic Map

Chromosome X

52.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

ChrX:129749742-130465834 bp, + strand From VEGA annotation of GRCm38   716093 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68551  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

Gene Tree: Diap2

Human homologs

Human Homolog		DIAPH2, diaphanous homolog 2 (Drosophila)
NCBI Gene ID		1730
neXtProt AC		NX_O60879
Human Synonyms		DIA, DIA2, DRF2, POF, POF2
Human Chr (Location)		Xq21.33; chrX:95939662-96855597 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DIAPH2

Alleles and phenotypes

All alleles(54) : Targeted(3) Gene trapped(51)
Phenotype Images(16)

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	actin cytoskeleton organization, actin filament polymerization, ...
Component	cytoplasm, Golgi apparatus, ...
Function	actin binding, Rho GTPase binding

External Resources: FuncBase

Expression

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) cDNA(20) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000018669 (Evidence)
Ensembl Gene Model	ENSMUSG00000034480 (Evidence)
Entrez Gene	54004 (Evidence)
UniGene	10763
DFCI	TC1586695, TC1590410, TC1599266, TC1623992
DoTS	DT.101354026, DT.101722912, DT.102557474, DT.40146760, DT.94269028
NIA Mouse Gene Index	U020179
Consensus CDS Project	CCDS41116.1, CCDS53180.1
International Mouse Knockout Project Status	Diap2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018669	VEGA Gene Model | MGI Sequence Detail	716093	C57BL/6J
transcript	OTTMUST00000044926	VEGA | MGI Sequence Detail	3742	Not Applicable
polypeptide	OTTMUSP00000020189	VEGA | MGI Sequence Detail	1102	Not Applicable

All sequences(54) RefSeq(3) UniProt(6)

Polymorphisms

SNPs(1318 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015425	Actin-binding FH2
InterPro	IPR003104	Actin-binding FH2/DRF autoregulatory
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR014767	Diaphanous autoregulatory
InterPro	IPR010472	Diaphanous FH3
InterPro	IPR010473	Diaphanous GTPase-binding
InterPro	IPR010465	DRF autoregulatory
InterPro	IPR014768	GTPase-binding/formin homology 3
Protein Ontology	PR:000006476	protein diaphanous 2

References

(Earliest) J:47262 Bione S, et al., A human homologue of the Drosophila melanogaster diaphanous gene is disrupted in a patient with premature ovarian failure: evidence for conserved function in oogenesis and implications for human sterility. Am J Hum Genet. 1998 Mar;62(3):533-41
(Latest) J:163340 Cox BJ, et al., Phenotypic annotation of the mouse X chromosome. Genome Res. 2010 Aug;20(8):1154-64
All references(35)

Other accession IDs

MGI:2444333