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Lpar2
Gene Detail
 Symbol
Name
ID
Lpar2
lysophosphatidic acid receptor 2
MGI:1858422
Synonyms Edg4, LPA2
Feature Type protein coding gene
Genetic Map
Chromosome 8
33.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:69822565-69831102 bp, + strand
From NCBI annotation of GRCm38

  8538 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3465  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: LPAR1/S1PR1-like lysophospholipid receptor
Gene Tree: Lpar2

Human
homologs
Human Homolog LPAR2, lysophosphatidic acid receptor 2
NCBI Gene ID 9170
neXtProt AC  NX_Q9HBW0
Human Synonyms  EDG4, EDG-4, LPA2, LPA-2
Human Chr (Location)  19p12; chr19:19623655-19628230 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Animals homozyogous for a targeted mutation appear phenotypically normal.
 
Interactions
Lpar2 interacts with 389 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process activation of MAPK activity, G-protein coupled receptor signaling pathway, ...
Component cell surface, endocytic vesicle, ...
Function G-protein coupled receptor activity, PDZ domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (209)    Tissues (110)    Images (44)
Theiler Stages: 13, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 184
Northern blot 24
RT-PCR 1
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) cDNA(27) Primer pair(4) Other(3)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000031861 (Evidence)
Entrez Gene53978 (Evidence)
UniGene23253
DFCITC1624331, TC1656528, TC1691752
DoTSDT.101189582, DT.40157897, DT.40179489, DT.91326784
NIA Mouse Gene IndexU009409
Consensus CDS ProjectCCDS40362.1
International Mouse Knockout Project StatusLpar2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 53978 NCBI Gene Model | MGI Sequence Detail 8538 C57BL/6J ±  kb
transcript NM_020028 RefSeq | MGI Sequence Detail 5701 C57BL/6 
polypeptide NP_064412 RefSeq | MGI Sequence Detail 348 C57BL/6 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(1)
Polymorphisms PCR(1) : SNPs within 2kb(111 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR004065 Lysophosphatidic acid receptor
InterPro IPR004066 Lysophosphatidic acid receptor EDG-4
Protein Ontology PR:000001685 lysophosphatidic acid receptor 2
References (Earliest) J:10212 Morris MD, et al., Lysosome lipid storage disorder in NCTR-BALB/c mice. I. Description of the disease and genetics. Am J Pathol. 1982 Aug;108(2):140-9
(Latest) J:210684 David M, et al., Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity. J Biol Chem. 2014 Mar 7;289(10):6551-64
All references(58)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory