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Lpar2 Gene Detail
Summary
  • Symbol
    Lpar2
  • Name
    lysophosphatidic acid receptor 2
  • Synonyms
    Edg4, LPA2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858422
    NCBI Gene: 53978
  • Gene Overview
    MyGene.info: LPAR2
Location & Maps
more
  • Sequence Map
    Chr8:69822565-69831102 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8538 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 33.91 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    LPAR2, lysophosphatidic acid receptor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LPAR2, lysophosphatidic acid receptor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EDG4, EDG-4, LPA2, LPA-2
  • Links
    NCBI Gene ID: 9170
    neXtProt AC: NX_Q9HBW0

  • Chr Location
    19p12; chr19:19623655-19628930 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Lpar2
  • Incidental Mutations
Animals homozyogous for a targeted mutation appear phenotypically normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 53978 NCBI Gene Model | MGI Sequence Detail 8538 C57BL/6J ±  kb
transcript NM_020028 RefSeq | MGI Sequence Detail 5701 C57BL/6  
polypeptide NP_064412 RefSeq | MGI Sequence Detail 348 C57BL/6  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    107 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000001685 lysophosphatidic acid receptor 2
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR004065 Lysophosphatidic acid receptor
    IPR004066 Lysophosphatidic acid receptor EDG-4
Molecular
Reagents
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  • All nucleic 34
    cDNA 27
    Primer pair 4
    Other 3

    Microarray probesets 4
References
more
  • Summaries
    All 53
    Developmental Gene Expression 13
    Gene Ontology 2
    Phenotypes 19
  • Earliest
    J:10212 Morris MD, et al., Lysosome lipid storage disorder in NCTR-BALB/c mice. I. Description of the disease and genetics. Am J Pathol. 1982 Aug;108(2):140-9
  • Latest
    J:210684 David M, et al., Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity. J Biol Chem. 2014 Mar 7;289(10):6551-64

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory