Lpar2
Gene Detail

Symbol Name ID

Lpar2 lysophosphatidic acid receptor 2 MGI:1858422

Synonyms

Edg4, LPA2

Feature Type

protein coding gene

Genetic Map

Chromosome 8

33.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:69822565-69831102 bp, + strand From NCBI annotation of GRCm38   8538 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3465  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: LPAR1/S1PR1-like lysophospholipid receptor
Gene Tree: Lpar2

Human homologs

Human Homolog		LPAR2, lysophosphatidic acid receptor 2
NCBI Gene ID		9170
neXtProt AC		NX_Q9HBW0
Human Synonyms		EDG4, EDG-4, LPA2, LPA-2
Human Chr (Location)		19p12; chr19:19734464-19739039 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Animals homozyogous for a targeted mutation appear phenotypically normal.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	activation of MAPK activity, G-protein coupled receptor signaling pathway, ...
Component	cell surface, endocytic vesicle, ...
Function	G-protein coupled receptor activity, PDZ domain binding, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (159)    Tissues (73)    Images (30)
Theiler Stages: 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	134
Northern blot	24
RT-PCR	1

cDNA source data(26)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(32) cDNA(26) Primer pair(3) Other(3)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000031861 (Evidence)
Entrez Gene	53978 (Evidence)
UniGene	23253
DFCI	TC1624331, TC1656528, TC1691752
DoTS	DT.101189582, DT.40157897, DT.40179489, DT.91326784
NIA Mouse Gene Index	U009409
Consensus CDS Project	CCDS40362.1
International Mouse Knockout Project Status	Lpar2

Sequences

Length	Strain/Species
genomic	53978	NCBI Gene Model | MGI Sequence Detail	8538	C57BL/6J
transcript	NM_020028	RefSeq | MGI Sequence Detail	5701	C57BL/6
polypeptide	NP_064412	RefSeq | MGI Sequence Detail	348	C57BL/6

All sequences(27) RefSeq(2) UniProt(1)

Polymorphisms

PCR(1) : SNPs(63 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR004065	Lysophosphatidic acid receptor
InterPro	IPR004066	Lysophosphatidic acid receptor EDG-4
Protein Ontology	PR:000001685	lysophosphatidic acid receptor 2

References

(Earliest) J:10212 Morris MD, et al., Lysosome lipid storage disorder in NCTR-BALB/c mice. I. Description of the disease and genetics. Am J Pathol. 1982 Aug;108(2):140-9
(Latest) J:194801 Cheng HY, et al., Lysophosphatidic acid signaling protects pulmonary vasculature from hypoxia-induced remodeling. Arterioscler Thromb Vasc Biol. 2012 Jan;32(1):24-32
All references(56)