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Rfx5
Gene Detail
 Symbol
Name
ID
Rfx5
regulatory factor X, 5 (influences HLA class II expression)
MGI:1858421
Feature Type protein coding gene
Genetic Map
Chromosome 3
40.74 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:94954075-94961561 bp, + strand
From VEGA annotation of GRCm38

  7487 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Gene Tree: Rfx5
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(7) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have absent or decreased expression of MHC-II complexes on antigen presenting cells, which leads to reduced numbers of CD4+ thymocytes and T cells.
 
Interactions
Rfx5 interacts with 406 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process negative regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-templated, ...
Component nucleus
Function DNA binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (141)    Tissues (73)    Images (24)
Theiler Stages: 2, 3, 4, 5, 15, 17, 19, 21, 23, 27, 28
Assay TypeResults
RNA in situ 133
RT-PCR 8
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(14) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000019670 (Evidence)
Ensembl Gene ModelENSMUSG00000005774 (Evidence)
Entrez Gene53970 (Evidence)
NIA Mouse Gene IndexU003551
Consensus CDS ProjectCCDS17598.1
International Mouse Knockout Project StatusRfx5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019670 VEGA Gene Model | MGI Sequence Detail 7487 C57BL/6J ±  kb
transcript OTTMUST00000082651 VEGA | MGI Sequence Detail 4333 Not Applicable 
polypeptide OTTMUSP00000044332 VEGA | MGI Sequence Detail 658 Not Applicable 

For the selected sequences
All sequences(108) RefSeq(18) UniProt(9)
Polymorphisms SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003150 DNA-binding RFX-type winged-helix domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000013927 DNA-binding protein RFX5
References (Earliest) J:67941 Clausen BE, et al., Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice. Immunity. 1998 Feb;8(2):143-55
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory