About   Help   FAQ
Sec61a1 Gene Detail
Summary
  • Symbol
    Sec61a1
  • Name
    Sec61 alpha 1 subunit (S. cerevisiae)
  • Synonyms
    Sec61a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858417
    NCBI Gene: 53421
  • Gene Overview
    MyGene.info: SEC61A1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:88503579-88518905 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15327 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 39.51 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SEC61A1, Sec61 translocon alpha 1 subunit
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SEC61A1, Sec61 translocon alpha 1 subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HNFJ4, HSEC61, SEC61, SEC61A
  • Links
    NCBI Gene ID: 29927
    neXtProt AC: NX_P61619
    UniProt: P61619

  • Chr Location
    3q21.3; chr3:128052369-128071683 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit decreased body weight, hyperglycemia, hypoinsulinemia, impaired glucose tolerance, apoptosis of beta-cells, and enlarged and pale liver with hepatic steatosis and cirrhosis when fed a high fat diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023092 VEGA Gene Model | MGI Sequence Detail 15327 C57BL/6J ±  kb
    transcript OTTMUST00000055761 VEGA | MGI Sequence Detail 3172 Not Applicable  
    polypeptide OTTMUSP00000026742 VEGA | MGI Sequence Detail 476 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      109 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1353628, MGI:2141359
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 10
    • Earliest
      J:77390 Dudek J, et al., A novel type of co-chaperone mediates transmembrane recruitment of DnaK-like chaperones to ribosomes. EMBO J. 2002 Jun 17;21(12):2958-67
    • Latest
      J:237692 Bolar NA, et al., Heterozygous Loss-of-Function SEC61A1 Mutations Cause Autosomal-Dominant Tubulo-Interstitial and Glomerulocystic Kidney Disease with Anemia. Am J Hum Genet. 2016 Jul 07;99(1):174-87

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory