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Ddx20 Gene Detail
Summary
  • Symbol
    Ddx20
  • Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
  • Synonyms
    dp103, GEMIN3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858415
    NCBI Gene: 53975
  • Gene Overview
    MyGene.info: DDX20
Location & Maps
more
  • Sequence Map
    Chr3:105678270-105687574 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9305 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DDX20, DEAD-box helicase 20
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DDX20, DEAD-box helicase 20
    Orthology source: HomoloGene
  • Synonyms
    DP103, GEMIN3
  • Links
    NCBI Gene ID: 11218
    neXtProt AC: NX_Q9UHI6

  • Chr Location
    1p21.1-p13.2; chr1:111755568-111767577 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Ddx20
  • Incidental Mutations
Mice homozygous for a null allele fail to implant and develop past the 2-cell stage. Heterozygous null females are viable, healthy and fertile but show increased ovary weight, a greater number of empty follicles, a prolonged estrous phase, and reduced nocturnal and stress-induced serum ACTH levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029585 VEGA Gene Model | MGI Sequence Detail 9305 C57BL/6J ±  kb
transcript OTTMUST00000073374 VEGA | MGI Sequence Detail 2905 Not Applicable  
polypeptide OTTMUSP00000037961 VEGA | MGI Sequence Detail 825 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    71 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000029384 ATP-dependent RNA helicase DDX20
  • EC
  • InterPro Domains
    IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
    IPR011545 DEAD/DEAH box helicase domain
    IPR001650 Helicase, C-terminal
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR014014 RNA helicase, DEAD-box type, Q motif
Molecular
Reagents
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  • All nucleic 84
    cDNA 83
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 37
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 9
  • Earliest
    J:61764 Campbell L, et al., Direct interaction of Smn with dp103, a putative RNA helicase: a role for Smn in transcription regulation?. Hum Mol Genet. 2000 Apr 12;9(7):1093-100
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory