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Ddx20
Gene Detail
Symbol

Name
ID
Ddx20
DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
MGI:1858415
Synonyms
dp103, GEMIN3
Feature Type
protein coding gene
Genetic Map
Chromosome 3
46.43 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:105678270-105687574 bp, - strand
From VEGA annotation of GRCm38

  9305 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5214  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ddx20

Human
homologs
Human Homolog DDX20, DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
NCBI Gene ID 11218
neXtProt AC  NX_Q9UHI6
Human Synonyms  DP103, GEMIN3
Human Chr (Location)  1p21.1-p13.2; chr1:111755568-111767577 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele fail to implant and develop past the 2-cell stage. Heterozygous null females are viable, healthy and fertile but show increased ovary weight, a greater number of empty follicles, a prolonged estrous phase, and reduced nocturnal and stress-induced serum ACTH levels.
 
Interactions
Ddx20 interacts with 68 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process mRNA processing, negative regulation of transcription, DNA-templated, ...
Component cytoplasm, cytosol, ...
Function ATP binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (21)    Tissues (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 9
Northern blot 12
cDNA source data(82)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(84) cDNA(83) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000029585 (Evidence)
Ensembl Gene ModelENSMUSG00000027905 (Evidence)
Entrez Gene53975 (Evidence)
UniGene272826
DFCITC1577392, TC1711406
DoTSDT.488643, DT.97405540, DT.97405541
NIA Mouse Gene IndexU024472
EC3.6.4.13
Consensus CDS ProjectCCDS38581.1
International Mouse Knockout Project StatusDdx20
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029585 VEGA Gene Model | MGI Sequence Detail 9305 C57BL/6J ±  kb
transcript OTTMUST00000073374 VEGA | MGI Sequence Detail 2905 Not Applicable 
polypeptide OTTMUSP00000037961 VEGA | MGI Sequence Detail 825 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(70 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
InterPro IPR001650 Helicase, C-terminal
InterPro IPR014001 Helicase, superfamily 1/2, ATP-binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000629 RNA helicase, ATP-dependent, DEAD-box, conserved site
InterPro IPR014014 RNA helicase, DEAD-box type, Q motif
Protein Ontology PR:000029384 ATP-dependent RNA helicase DDX20
References
(Earliest) J:61764 Campbell L, et al., Direct interaction of Smn with dp103, a putative RNA helicase: a role for Smn in transcription regulation?. Hum Mol Genet. 2000 Apr 12;9(7):1093-100
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory