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Ngef Gene Detail
Summary
  • Symbol
    Ngef
  • Name
    neuronal guanine nucleotide exchange factor
  • Synonyms
    ephexin, Tims2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858414
    NCBI Gene: 53972
Location & Maps
more
  • Sequence Map
    Chr1:87476834-87573870 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      97037 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 44.42 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NGEF, neuronal guanine nucleotide exchange factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NGEF, neuronal guanine nucleotide exchange factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARHGEF27, EPHEXIN
  • Links
    NCBI Gene ID: 25791
    neXtProt AC: NX_Q8N5V2

  • Chr Location
    2q37; chr2:232878686-233013241 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 75120
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: NGEF
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Ngef
  • Incidental Mutations
Mice homozygous for a knock-out allele are viable and fertile and show no overt axonal phenotype; however, cultured retinal ganglion cells display defects in axonal outgrowth and ephrin-induced growth cone collapse.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036755 VEGA Gene Model | MGI Sequence Detail 97037 C57BL/6J ±  kb
transcript OTTMUST00000094294 VEGA | MGI Sequence Detail 3109 Not Applicable  
polypeptide OTTMUSP00000052407 VEGA | MGI Sequence Detail 710 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    442 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 37
    cDNA 30
    Primer pair 6
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1202845
References
more
  • Summaries
    All 33
    Developmental Gene Expression 7
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
  • Latest
    J:226616 Araujo DJ, et al., FoxP1 orchestration of ASD-relevant signaling pathways in the striatum. Genes Dev. 2015 Oct 15;29(20):2081-96

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory