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Nxf1
Gene Detail
Symbol

Name
ID
Nxf1
nuclear RNA export factor 1
MGI:1858330
Synonyms
Mex67, Mvb1, TAP, Tip associated protein
Feature Type
protein coding gene
Genetic Map
Chromosome 19
5.50 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr19:8757073-8772456 bp, + strand
From VEGA annotation of GRCm38

  15384 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38176  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NXF1
Gene Tree: Nxf1

Human
homologs
NXF1, nuclear RNA export factor 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10482
neXtProt AC: NX_Q9UBU9

Human Synonyms: MEX67, TAP

Human Chr (Location): 11q12-q13; chr11:62792126-62805492 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Endonuclease-mediated(1) Gene trapped(11) QTL(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for some alleles are able to suppress defects caused by retrovirus insertion mutations.
 
Interactions
Nxf1 interacts with 90 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process mRNA export from nucleus, poly(A)+ mRNA export from nucleus, ...
Component cell, intracellular, ...
Function mRNA binding, nucleocytoplasmic transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (22)    Tissues (22)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 20
RT-PCR 2
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nxf1    NEW 
Molecular
reagents
All nucleic(14) cDNA(13) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000044877 (Evidence)
Ensembl Gene Model ENSMUSG00000010097 (Evidence)
Entrez Gene 53319 (Evidence)
DFCI TC1628360, TC1573188, TC1764242
DoTS DT.101238802, DT.110860010, DT.110859963, DT.535203, DT.531445, DT.55279583
Consensus CDS Project CCDS29543.1, CCDS70930.1
International Mouse Phenotyping Consortium Status Nxf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044877 VEGA Gene Model | MGI Sequence Detail 15384 C57BL/6J ±  kb
transcript OTTMUST00000117915 VEGA | MGI Sequence Detail 2326 Not Applicable 
polypeptide OTTMUSP00000065862 VEGA | MGI Sequence Detail 618 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(4)
Polymorphisms
SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000011535 nuclear RNA export factor 1
References
(Earliest) J:40754 Hamilton BA, et al., The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. Neuron. 1997 May;18(5):711-22
(Latest) J:219914 Concepcion D, et al., Nxf1 Natural Variant E610G Is a Semi-dominant Suppressor of IAP-Induced RNA Processing Defects. PLoS Genet. 2015 Apr;11(4):e1005123
All references(35)
Other
accession IDs
MGI:1194888

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory