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Nxf1 Gene Detail
Summary
  • Symbol
    Nxf1
  • Name
    nuclear RNA export factor 1
  • Synonyms
    Mex67, Mvb1, TAP, Tip associated protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858330
    NCBI Gene: 53319
  • Gene Overview
    MyGene.info: NXF1
Location & Maps
more
  • Sequence Map
    Chr19:8757073-8772456 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15384 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 5.50 cM, cytoband A
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    NXF1, nuclear RNA export factor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NXF1, nuclear RNA export factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MEX67, TAP
  • Links
    NCBI Gene ID: 10482
    neXtProt AC: NX_Q9UBU9

  • Chr Location
    11q12.3; chr11:62792126-62805492 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 38176
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NXF1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    16 phenotypes from multigenic genotypes
    9 phenotype references
  • All Mutations and Alleles
    16
  • Endonuclease-mediated
    1
  • Gene trapped
    11
  • QTL
    2
  • Targeted
    2
  • Incidental Mutations
Mice homozygous for some alleles are able to suppress defects caused by retrovirus insertion mutations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044877 VEGA Gene Model | MGI Sequence Detail 15384 C57BL/6J ±  kb
transcript OTTMUST00000117915 VEGA | MGI Sequence Detail 2326 Not Applicable  
polypeptide OTTMUSP00000065862 VEGA | MGI Sequence Detail 618 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    34 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 13
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:1194888
References
more
  • Summaries
    All 35
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:40754 Hamilton BA, et al., The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. Neuron. 1997 May;18(5):711-22
  • Latest
    J:236184 Saito S, et al., Leukemia-Associated Nup214 Fusion Proteins Disturb the XPO1-Mediated Nuclear-Cytoplasmic Transport Pathway and Thereby the NF-kappaB Signaling Pathway. Mol Cell Biol. 2016 Jul 1;36(13):1820-35

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory