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Nxf1 Gene Detail
Summary
  • Symbol
    Nxf1
  • Name
    nuclear RNA export factor 1
  • Synonyms
    Mex67, Mvb1, TAP, Tip associated protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858330
    NCBI Gene: 53319
  • Gene Overview
    MyGene.info: NXF1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:8757103-8770910 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 5.50 cM, cytoband A
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    34 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858330
protein coding gene Chr19:8757073-8772475 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024807
protein coding gene Chr19:6030819-6048883 (+)
A/J MGP_AJ_G0024775
protein coding gene Chr19:5709049-5724473 (+)
AKR/J MGP_AKRJ_G0024750
protein coding gene Chr19:5797380-5812618 (+)
BALB/cJ MGP_BALBcJ_G0024775
protein coding gene Chr19:5813282-5829207 (+)
C3H/HeJ MGP_C3HHeJ_G0024541
protein coding gene Chr19:5878230-5893617 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025222
protein coding gene Chr19:6149992-6170134 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022651
protein coding gene Chr19:5952928-5969090 (+)
CAST/EiJ MGP_CASTEiJ_G0024014
protein coding gene Chr19:5526642-5544952 (+)
CBA/J MGP_CBAJ_G0024515
protein coding gene Chr19:6270148-6288623 (+)
DBA/2J MGP_DBA2J_G0024642
protein coding gene Chr19:5539690-5556003 (+)
FVB/NJ MGP_FVBNJ_G0024609
protein coding gene Chr19:5614916-5630133 (+)
LP/J MGP_LPJ_G0024729
protein coding gene Chr19:5919959-5937426 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024636
protein coding gene Chr19:6135623-6153198 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025271
protein coding gene Chr19:5842181-5857598 (+)
PWK/PhJ MGP_PWKPhJ_G0023759
protein coding gene Chr19:5205352-5224426 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0024076
protein coding gene Chr19:5809229-5825311 (+)



Homology
more
  • Human Ortholog
    NXF1, nuclear RNA export factor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NXF1, nuclear RNA export factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MEX67, TAP
  • Links
    NCBI Gene ID: 10482
    neXtProt AC: NX_Q9UBU9
    UniProt: Q9UBU9

  • Chr Location
    11q12.3; chr11:62792125-62805492 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 38176
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NXF1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotypes from multigenic genotypes
    9 phenotype references
Mice homozygous for some alleles are able to suppress defects caused by retrovirus insertion mutations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 53319 NCBI Gene Model | MGI Sequence Detail 13808 C57BL/6J ±  kb
transcript NM_001276704 RefSeq | MGI Sequence Detail 4035 C57BL/6  
polypeptide NP_058093 RefSeq | MGI Sequence Detail 618 FVB/N  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 14
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:1194888
References
more
  • Summaries
    All 41
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:40754 Hamilton BA, et al., The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. Neuron. 1997 May;18(5):711-22
  • Latest
    J:236184 Saito S, et al., Leukemia-Associated Nup214 Fusion Proteins Disturb the XPO1-Mediated Nuclear-Cytoplasmic Transport Pathway and Thereby the NF-kappaB Signaling Pathway. Mol Cell Biol. 2016 Jul 1;36(13):1820-35

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory