Nxf1
Gene Detail

Symbol Name ID

Nxf1 nuclear RNA export factor 1 MGI:1858330

Synonyms

Mex67, Mvb1, TAP, Tip associated protein

Feature Type

protein coding gene

Genetic Map

Chromosome 19

5.50 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr19:8757103-8770909 bp, + strand From Ensembl annotation of GRCm38   13807 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:38176  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Nxf1

Human homologs

Human Homolog		NXF1, nuclear RNA export factor 1
NCBI Gene ID		10482
neXtProt AC		NX_Q9UBU9
Human Synonyms		MEX67, TAP
Human Chr (Location)		11q12-q13; chr11:62559598-62572964 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(15) : Targeted(2) Gene trapped(11) QTL(2)
 

Mice homozygous for some alleles are able to suppress defects caused by retrovirus insertion mutations.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	mRNA export from nucleus, mRNA transport, ...
Component	cytoplasm, intracellular, ...
Function	mRNA binding, nucleocytoplasmic transporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (22)    Tissues (22)    Images (3)
Theiler Stages: 21, 28

Assay Type	Results
RNA in situ	20
RT-PCR	2

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) cDNA(13) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000010097 (Evidence)
Entrez Gene	53319 (Evidence)
DFCI	TC1573188, TC1628360, TC1764242
DoTS	DT.101238802, DT.110859963, DT.110860010, DT.531445, DT.535203, DT.55279583
Consensus CDS Project	CCDS29543.1
International Mouse Knockout Project Status	Nxf1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000010097	Ensembl Gene Model | MGI Sequence Detail	13807	C57BL/6J
transcript	ENSMUST00000010241	Ensembl | MGI Sequence Detail	2283	Not Applicable
polypeptide	ENSMUSP00000010241	Ensembl | MGI Sequence Detail	618	Not Applicable

All sequences(33) RefSeq(4) UniProt(2)

Polymorphisms

SNPs(30 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001611	Leucine-rich repeat
InterPro	IPR015245	Nuclear RNA export factor Tap, RNA-binding domain
InterPro	IPR002075	Nuclear transport factor 2
InterPro	IPR018222	Nuclear transport factor 2, Eukaryote
InterPro	IPR012677	Nucleotide-binding, alpha-beta plait
InterPro	IPR005637	TAP C-terminal (TAP-C) domain
InterPro	IPR003603	U2A'/phosphoprotein 32 family A, C-terminal
InterPro	IPR009060	UBA-like
Protein Ontology	PR:000011535	nuclear RNA export factor 1

References

(Earliest) J:40754 Hamilton BA, et al., The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. Neuron. 1997 May;18(5):711-22
(Latest) J:177918 Quille ML, et al., High-throughput analysis of promoter occupancy reveals new targets for Arx, a gene mutated in mental retardation and interneuronopathies. PLoS One. 2011;6(9):e25181
All references(37)

Other accession IDs

MGI:1194888