About   Help   FAQ
Nxf1
Gene Detail
 Symbol
Name
ID
Nxf1
nuclear RNA export factor 1
MGI:1858330
Synonyms Mex67, Mvb1, TAP, Tip associated protein
Feature Type protein coding gene
Genetic Map
Chromosome 19
5.50 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr19:8757073-8772456 bp, + strand
From VEGA annotation of GRCm38

  15384 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38176  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Nxf1

Human
homologs
Human Homolog NXF1, nuclear RNA export factor 1
NCBI Gene ID 10482
neXtProt AC  NX_Q9UBU9
Human Synonyms  MEX67, TAP
Human Chr (Location)  11q12-q13; chr11:62792124-62805492 (-)  GRCh38
Alleles
and
phenotypes
All alleles(15) : Gene trapped(11) QTL(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for some alleles are able to suppress defects caused by retrovirus insertion mutations.
 
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process mRNA export from nucleus, mRNA transport, ...
Component cell, cytoplasm, ...
Function mRNA binding, nucleocytoplasmic transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (22)    Tissues (22)    Images (3)
Theiler Stages: 21, 28
Assay TypeResults
RNA in situ 20
RT-PCR 2
cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(14) cDNA(13) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000044877 (Evidence)
Ensembl Gene ModelENSMUSG00000010097 (Evidence)
Entrez Gene53319 (Evidence)
DFCITC1573188, TC1628360, TC1764242
DoTSDT.101238802, DT.110859963, DT.110860010, DT.531445, DT.535203, DT.55279583
Consensus CDS ProjectCCDS29543.1, CCDS70930.1
International Mouse Knockout Project StatusNxf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044877 VEGA Gene Model | MGI Sequence Detail 15384 C57BL/6J ±  kb
transcript OTTMUST00000117915 VEGA | MGI Sequence Detail 2326 Not Applicable 
polypeptide OTTMUSP00000065862 VEGA | MGI Sequence Detail 618 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(4) UniProt(7)
Polymorphisms SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001611 Leucine-rich repeat
InterPro IPR015245 Nuclear RNA export factor Tap, RNA-binding domain
InterPro IPR002075 Nuclear transport factor 2
InterPro IPR018222 Nuclear transport factor 2, Eukaryote
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR005637 TAP C-terminal (TAP-C) domain
InterPro IPR003603 U2A'/phosphoprotein 32 family A, C-terminal
InterPro IPR009060 UBA-like
Protein Ontology PR:000011535 nuclear RNA export factor 1
References (Earliest) J:40754 Hamilton BA, et al., The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. Neuron. 1997 May;18(5):711-22
(Latest) J:177918 Quille ML, et al., High-throughput analysis of promoter occupancy reveals new targets for Arx, a gene mutated in mental retardation and interneuronopathies. PLoS One. 2011;6(9):e25181
All references(38)
Other
accession IDs
MGI:1194888

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory