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Timm23 Gene Detail
Summary
  • Symbol
    Timm23
  • Name
    translocase of inner mitochondrial membrane 23
  • Synonyms
    MGC:46821, Tim23
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858317
    NCBI Gene: 53600
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:32180166-32201891 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 19.40 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    80 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858317
protein coding gene Chr14:32180162-32201898 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021141
protein coding gene Chr14:25414198-25436256 (-)
A/J MGP_AJ_G0021089
protein coding gene Chr14:24443403-24467351 (-)
AKR/J MGP_AKRJ_G0021066
protein coding gene Chr14:25589956-25615302 (-)
BALB/cJ MGP_BALBcJ_G0021093
protein coding gene Chr14:24621067-24644216 (-)
C3H/HeJ MGP_C3HHeJ_G0020876
protein coding gene Chr14:25467147-25488772 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021525
protein coding gene Chr14:26429982-26452652 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019088
protein coding gene Chr14:24508987-24530674 (-)
CAST/EiJ MGP_CASTEiJ_G0020401
protein coding gene Chr14:25258596-25280813 (-)
CBA/J MGP_CBAJ_G0020843
protein coding gene Chr14:27413471-27439231 (-)
DBA/2J MGP_DBA2J_G0020965
protein coding gene Chr14:24476322-24498217 (-)
FVB/NJ MGP_FVBNJ_G0020949
protein coding gene Chr14:24438583-24462788 (-)
LP/J MGP_LPJ_G0021034
protein coding gene Chr14:25736461-25757714 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020975
protein coding gene Chr14:26651845-26675374 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021558
protein coding gene Chr14:25364287-25386299 (-)
PWK/PhJ MGP_PWKPhJ_G0020149
protein coding gene Chr14:23947539-23970985 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019973
protein coding gene Chr14:24970766-24995622 (-)
WSB/EiJ MGP_WSBEiJ_G0020456
protein coding gene Chr14:25426305-25447868 (-)



Homology
more
  • Human Ortholog
    TIMM23, translocase of inner mitochondrial membrane 23
  • Vertebrate Orthologs
    12
  • Human Ortholog
    TIMM23, translocase of inner mitochondrial membrane 23
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TIM23
  • Links
    NCBI Gene ID: 100287932
    neXtProt AC: NX_O14925
    UniProt: O14925

  • Chr Location
    chr10:45972453-46003742 (+)  GRCh38.p7

  • Human Ortholog
    TIMM23B, translocase of inner mitochondrial membrane 23 homolog B
    Orthology source: HGNC
  • Links
    NCBI Gene ID: 100652748
    UniProt: Q5SRD1

  • Chr Location
    chr10:49942033-49988221 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele die prior to E3.5. Mice heterogygous for this allele exhibit background sensitive premature aging and increased mortality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53600 NCBI Gene Model | MGI Sequence Detail 21726 C57BL/6J ±  kb
    transcript NM_016897 RefSeq | MGI Sequence Detail 1162 C57BL/6  
    polypeptide NP_058593 RefSeq | MGI Sequence Detail 209 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 1
      cDNA 10

      Microarray probesets 6
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 8
    • Earliest
      J:63697 Underhill DA, et al., Transcription mapping and expression analysis of candidate genes in the vicinity of the mouse Loop-tail mutation. Mamm Genome. 2000 Aug;11(8):633-8
    • Latest
      J:179027 Engl G, et al., Alterations in expression levels of deafness dystonia protein 1 affect mitochondrial morphology. Hum Mol Genet. 2012 Jan 15;21(2):287-99

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory