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Timm23
Gene Detail
Symbol

Name
ID
Timm23
translocase of inner mitochondrial membrane 23
MGI:1858317
Synonyms
MGC:46821, Tim23
Feature Type
protein coding gene
Genetic Map
Chromosome 14
19.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr14:32180162-32201898 bp, - strand
From VEGA annotation of GRCm38

  21737 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9651  Vertebrate Homology Class
1 human; 1 mouse; 3 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TIMM23
Gene Tree: Timm23

Human
homologs
TIMM23, translocase of inner mitochondrial membrane 23 homolog (yeast)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 100287932
neXtProt AC: NX_O14925

Human Synonyms: TIM23

Human Chr (Location): chr10:45972453-46003742 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(38) : Gene trapped(36) Targeted(2)
Incidental mutations (data from APF )
 
Mice homozygous for a gene trapped allele die prior to E3.5. Mice heterogygous for this allele exhibit background sensitive premature aging and increased mortality.
 
Interactions
Timm23 interacts with 97 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Component integral component of mitochondrial inner membrane, mitochondrial inner membrane, ...
Function enzyme binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (77)    Tissues (14)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 70
In situ reporter (knock in) 3
Western blot 4
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase timm23 ; ZFIN timm23a    NEW 
Molecular
reagents
All nucleic(10) Genomic(1) cDNA(9)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000036490 (Evidence)
Ensembl Gene Model ENSMUSG00000013701 (Evidence)
Entrez Gene 53600 (Evidence)
DFCI TC1572508, TC1749669
NIA Mouse Gene Index U129548, U062919, U040944, U349673, U135210
Consensus CDS Project CCDS36864.1
International Mouse Phenotyping Consortium Status Timm23
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036490 VEGA Gene Model | MGI Sequence Detail 21737 C57BL/6J ±  kb
transcript OTTMUST00000093545 VEGA | MGI Sequence Detail 1173 Not Applicable 
polypeptide OTTMUSP00000051926 VEGA | MGI Sequence Detail 209 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(2)
Polymorphisms
SNPs within 2kb(80 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000016347 mitochondrial import inner membrane translocase subunit Tim23
References
(Earliest) J:63697 Underhill DA, et al., Transcription mapping and expression analysis of candidate genes in the vicinity of the mouse Loop-tail mutation. Mamm Genome. 2000 Aug;11(8):633-8
(Latest) J:179027 Engl G, et al., Alterations in expression levels of deafness dystonia protein 1 affect mitochondrial morphology. Hum Mol Genet. 2012 Jan 15;21(2):287-99
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory