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Uba2
Gene Detail
Symbol

Name
ID
Uba2
ubiquitin-like modifier activating enzyme 2
MGI:1858313
Synonyms
anthracycline-associated resistance, Arx, SAE2, Sumo-1 activating enzyme subunit 2, UBA2, Uble1b
Feature Type
protein coding gene
Genetic Map
Chromosome 7
19.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:34140689-34169599 bp, - strand
From VEGA annotation of GRCm38

  28911 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4018  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: UBA2
Protein SuperFamily: SUMO-activating enzyme subunit 2
Gene Tree: Uba2

Human
homologs
UBA2, ubiquitin-like modifier activating enzyme 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10054
neXtProt AC: NX_Q9UBT2

Human Synonyms: ARX, HRIHFB2115, SAE2

Human Chr (Location): 19q12; chr19:34428176-34469893 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(89) : Gene trapped(87) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Uba2 interacts with 197 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process protein sumoylation
Component cytoplasm, cytosol, ...
Function ATP binding, coenzyme F420-0 gamma-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(260)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase uba2    NEW 
Molecular
reagents
All nucleic(260) cDNA(260)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000008405 (Evidence)
Ensembl Gene Model ENSMUSG00000052997 (Evidence)
Entrez Gene 50995 (Evidence)
UniGene 27560
DFCI TC1616188, TC1707280, TC1573993
DoTS DT.111006141, DT.101392932, DT.101708012, DT.111006167, DT.496251
NIA Mouse Gene Index U028423
EC 6.3.2.-
Consensus CDS Project CCDS21136.1
International Mouse Phenotyping Consortium Status Uba2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008405 VEGA Gene Model | MGI Sequence Detail 28911 C57BL/6J ±  kb
transcript OTTMUST00000019060 VEGA | MGI Sequence Detail 2578 Not Applicable 
polypeptide OTTMUSP00000008744 VEGA | MGI Sequence Detail 638 Not Applicable 

For the selected sequences
All sequences(103) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(289 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009036 Molybdenum cofactor biosynthesis, MoeB
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR000594 UBA/THIF-type NAD/FAD binding fold
InterPro IPR019572 Ubiquitin-activating enzyme
InterPro IPR018074 Ubiquitin-activating enzyme, E1, active site
InterPro IPR000127 Ubiquitin-activating enzyme repeat
InterPro IPR023280 Ubiquitin-like 1 activating enzyme, catalytic cysteine domain
Protein Ontology PR:000016951 SUMO-activating enzyme subunit 2
References
(Earliest) J:63475 Schwienhorst I, et al., SUMO conjugation and deconjugation. Mol Gen Genet. 2000 Jun;263(5):771-86
(Latest) J:186944 Ban R, et al., Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis. Genes Cells. 2011 Jun;16(6):652-69
All references(43)
Other
accession IDs
MGI:2141854

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory