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Uba2 Gene Detail
Summary
  • Symbol
    Uba2
  • Name
    ubiquitin-like modifier activating enzyme 2
  • Synonyms
    anthracycline-associated resistance, Arx, SAE2, Sumo-1 activating enzyme subunit 2, UBA2, Uble1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858313
    NCBI Gene: 50995
  • Gene Overview
    MyGene.info: UBA2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:34140697-34168585 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 19.41 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    285 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858313
protein coding gene Chr7:34140688-34169599 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032072
protein coding gene Chr7:33395947-33425602 (-)
A/J MGP_AJ_G0032051
protein coding gene Chr7:32563289-32592393 (-)
AKR/J MGP_AKRJ_G0031985
protein coding gene Chr7:33345618-33376017 (-)
BALB/cJ MGP_BALBcJ_G0032059
protein coding gene Chr7:32851071-32883067 (-)
C3H/HeJ MGP_C3HHeJ_G0031776
protein coding gene Chr7:34233629-34264368 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032536
protein coding gene Chr7:35110237-35140152 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029569
protein coding gene Chr7:33319695-33348819 (-)
CAST/EiJ MGP_CASTEiJ_G0031111
protein coding gene Chr7:25343819-25383947 (-)
CBA/J MGP_CBAJ_G0031744
protein coding gene Chr7:36194904-36226248 (-)
DBA/2J MGP_DBA2J_G0031896
protein coding gene Chr7:32430458-32459260 (-)
FVB/NJ MGP_FVBNJ_G0031851
protein coding gene Chr7:32337972-32368864 (-)
LP/J MGP_LPJ_G0031973
protein coding gene Chr7:33765822-33796456 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031889
protein coding gene Chr7:35236076-35266855 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032551
protein coding gene Chr7:32864749-32899586 (-)
PWK/PhJ MGP_PWKPhJ_G0030833
protein coding gene Chr7:25739246-25769537 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030668
protein coding gene Chr7:22426987-22460111 (-)
WSB/EiJ MGP_WSBEiJ_G0031221
protein coding gene Chr7:33418101-33448950 (-)



Homology
more
  • Human Ortholog
    UBA2, ubiquitin like modifier activating enzyme 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UBA2, ubiquitin like modifier activating enzyme 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARX, HRIHFB2115, SAE2
  • Links
    NCBI Gene ID: 10054
    neXtProt AC: NX_Q9UBT2
    UniProt: Q9UBT2

  • Chr Location
    19q13.11; chr19:34428176-34469893 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 50995 NCBI Gene Model | MGI Sequence Detail 27889 C57BL/6J ±  kb
transcript NM_016682 RefSeq | MGI Sequence Detail 2524 C57BL/6  
polypeptide Q9Z1F9 UniProt | EBI | MGI Sequence Detail 638 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000016951 SUMO-activating enzyme subunit 2
  • EC
  • InterPro Domains
    IPR032426 SUMO-activating enzyme subunit 2, C-terminal domain
    IPR030661 SUMO-activating enzyme subunit Uba2
    IPR000594 THIF-type NAD/FAD binding fold
    IPR035985 Ubiquitin-activating enzyme
    IPR023318 Ubiquitin activating enzyme, alpha domain superfamily
    IPR018074 Ubiquitin-activating enzyme E1, conserved site
    IPR033127 Ubiquitin-activating enzyme E1, Cys active site
    IPR028077 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
Molecular
Reagents
less
  • All nucleic 262
    cDNA 261
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2141854
References
more
  • Summaries
    All 40
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:63475 Schwienhorst I, et al., SUMO conjugation and deconjugation. Mol Gen Genet. 2000 Jun;263(5):771-86
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory