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Uba2
Gene Detail
 Symbol
Name
ID
Uba2
ubiquitin-like modifier activating enzyme 2
MGI:1858313
Synonyms anthracycline-associated resistance, Arx, SAE2, Sumo-1 activating enzyme subunit 2, UBA2, Uble1b
Feature Type protein coding gene
Genetic Map
Chromosome 7
19.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:34140689-34169599 bp, - strand
From VEGA annotation of GRCm38

  28911 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4018  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: SUMO-activating enzyme subunit 2
Gene Tree: Uba2

Human
homologs
Human Homolog UBA2, ubiquitin-like modifier activating enzyme 2
NCBI Gene ID 10054
neXtProt AC  NX_Q9UBT2
Human Synonyms  ARX, SAE2
Human Chr (Location)  19q12; chr19:34428359-34469893 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(89) : Gene trapped(87) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Uba2 interacts with 197 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cellular protein modification process, protein sumoylation, ...
Component cytoplasm, cytosol, ...
Function ATP binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(260)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(260) cDNA(260)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000008405 (Evidence)
Ensembl Gene ModelENSMUSG00000052997 (Evidence)
Entrez Gene50995 (Evidence)
UniGene27560
DFCITC1573993, TC1616188, TC1707280
DoTSDT.101392932, DT.101708012, DT.111006141, DT.111006167, DT.496251
NIA Mouse Gene IndexU028423
EC6.3.2.-
Consensus CDS ProjectCCDS21136.1
International Mouse Knockout Project StatusUba2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008405 VEGA Gene Model | MGI Sequence Detail 28911 C57BL/6J ±  kb
transcript OTTMUST00000019060 VEGA | MGI Sequence Detail 2578 Not Applicable 
polypeptide OTTMUSP00000008744 VEGA | MGI Sequence Detail 638 Not Applicable 

For the selected sequences
All sequences(102) RefSeq(2) UniProt(5)
Polymorphisms SNPs within 2kb(289 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009036 Molybdenum cofactor biosynthesis, MoeB
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR000594 UBA/THIF-type NAD/FAD binding fold
InterPro IPR019572 Ubiquitin-activating enzyme
InterPro IPR018074 Ubiquitin-activating enzyme, E1, active site
InterPro IPR000127 Ubiquitin-activating enzyme repeat
InterPro IPR023280 Ubiquitin-like 1 activating enzyme, catalytic cysteine domain
Protein Ontology PR:000016951 SUMO-activating enzyme subunit 2
References (Earliest) J:63475 Schwienhorst I, et al., SUMO conjugation and deconjugation. Mol Gen Genet. 2000 Jun;263(5):771-86
(Latest) J:186944 Ban R, et al., Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis. Genes Cells. 2011 Jun;16(6):652-69
All references(45)
Other
accession IDs
MGI:2141854

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory