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Srpx Gene Detail
Summary
  • Symbol
    Srpx
  • Name
    sushi-repeat-containing protein
  • Synonyms
    drs-1, drs-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858306
    NCBI Gene: 51795
  • Gene Overview
    MyGene.info: SRPX
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:10037977-10117661 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 4.62 cM, cytoband A1.2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    411 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858306
protein coding gene ChrX:10037977-10117709 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035561
protein coding gene ChrX:4776876-4857870 (-)
A/J MGP_AJ_G0035538
protein coding gene ChrX:4877493-4956971 (-)
AKR/J MGP_AKRJ_G0035470
protein coding gene ChrX:4954179-5027613 (-)
BALB/cJ MGP_BALBcJ_G0035531
protein coding gene ChrX:4795438-4875952 (-)
C3H/HeJ MGP_C3HHeJ_G0035248
protein coding gene ChrX:4898157-4985393 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036061
protein coding gene ChrX:4850623-4933353 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032930
protein coding gene ChrX:3984870-4063665 (-)
CAST/EiJ MGP_CASTEiJ_G0034540
protein coding gene ChrX:4595898-4677609 (-)
CBA/J MGP_CBAJ_G0035217
protein coding gene ChrX:5237062-5325707 (-)
DBA/2J MGP_DBA2J_G0035370
protein coding gene ChrX:4793983-4875335 (-)
FVB/NJ MGP_FVBNJ_G0035317
protein coding gene ChrX:4635547-4717373 (-)
LP/J MGP_LPJ_G0035452
protein coding gene ChrX:4966186-5057273 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035360
protein coding gene ChrX:5112551-5206147 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036073
protein coding gene ChrX:4703189-4787003 (-)
PWK/PhJ MGP_PWKPhJ_G0034241
protein coding gene ChrX:4293982-4375025 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034082
protein coding gene ChrX:4759602-4843886 (-)
WSB/EiJ MGP_WSBEiJ_G0034676
protein coding gene ChrX:4777808-4860439 (-)



Homology
more
  • Human Ortholog
    SRPX, sushi repeat containing protein X-linked
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SRPX, sushi repeat containing protein X-linked
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DRS, ETX1, HEL-S-83p, SRPX1
  • Links
    NCBI Gene ID: 8406
    neXtProt AC: NX_P78539
    UniProt: P78539

  • Chr Location
    Xp11.4; chrX:38149335-38220924 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4598
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SRPX
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice either heterozygous or homozygous for a knock-out allele display increased sensitivity to malignant tumor formation at 7-12 months of age. In addition, homozygotes exhibit atypical lymphocyte morphhology and splenomegaly.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 51795 NCBI Gene Model | MGI Sequence Detail 79685 C57BL/6J ±  kb
    transcript NM_016911 RefSeq | MGI Sequence Detail 2435 C57BL/6  
    polypeptide Q9R0M3 UniProt | EBI | MGI Sequence Detail 464 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 30
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 24
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 3
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:237787 Liu X, et al., Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. BMC Immunol. 2016 Aug 02;17(1):25

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory