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Gal3st1 Gene Detail
Summary
  • Symbol
    Gal3st1
  • Name
    galactose-3-O-sulfotransferase 1
  • Synonyms
    3'-phosphoadenylylsulfate-galactosylceramide 3'-sulfotransferase, Cst, galactosylceramide sulfotransferase, GalCer sulfotransferase, Gcst
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858277
    NCBI Gene: 53897
  • Gene Overview
    MyGene.info: GAL3ST1
Location & Maps
more
  • Sequence Map
    Chr11:3983636-3999326 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15691 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 2.81 cM, cytoband A1
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GAL3ST1, galactose-3-O-sulfotransferase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GAL3ST1, galactose-3-O-sulfotransferase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CST
  • Links
    NCBI Gene ID: 9514
    neXtProt AC: NX_Q99999

  • Chr Location
    22q12.2; chr22:30554635-30574588 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit hindlimb weakness and progressive ataxia beginning at six weeks of age. Homozygous males exhibit sterility with a block in spermatogenesis prior to the first meiotic division.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005048 VEGA Gene Model | MGI Sequence Detail 15691 C57BL/6J ±  kb
transcript OTTMUST00000011236 VEGA | MGI Sequence Detail 1749 Not Applicable  
polypeptide OTTMUSP00000005240 VEGA | MGI Sequence Detail 423 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    61 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000007807 galactosylceramide sulfotransferase
  • EC
  • InterPro Domains
    IPR009729 Galactose-3-O-sulfotransferase
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 43
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 20
  • Earliest
    J:61464 Hirahara Y, et al., cDNA cloning, genomic cloning, and tissue-specific regulation of mouse cerebroside sulfotransferase. Eur J Biochem. 2000 Apr;267(7):1909-17
  • Latest
    J:216599 Marsching C, et al., Quantitative imaging mass spectrometry of renal sulfatides: validation by classical mass spectrometric methods. J Lipid Res. 2014 Nov;55(11):2343-53

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory