About   Help   FAQ
Gal3st1 Gene Detail
Summary
  • Symbol
    Gal3st1
  • Name
    galactose-3-O-sulfotransferase 1
  • Synonyms
    3'-phosphoadenylylsulfate-galactosylceramide 3'-sulfotransferase, Cst, galactosylceramide sulfotransferase, GalCer sulfotransferase, Gcst
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858277
    NCBI Gene: 53897
  • Gene Overview
    MyGene.info: GAL3ST1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:3983636-3999326 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 2.81 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    61 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858277
protein coding gene Chr11:3983636-3999328 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017970
protein coding gene Chr11:895429-911757 (+)
A/J MGP_AJ_G0017943
protein coding gene Chr11:916171-931572 (+)
AKR/J MGP_AKRJ_G0017907
protein coding gene Chr11:964677-979887 (+)
BALB/cJ MGP_BALBcJ_G0017911
protein coding gene Chr11:885975-901403 (+)
C3H/HeJ MGP_C3HHeJ_G0017724
protein coding gene Chr11:877996-893233 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018364
protein coding gene Chr11:979734-995515 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016022
protein coding gene Chr11:802812-819663 (+)
CAST/EiJ MGP_CASTEiJ_G0017286
protein coding gene Chr11:838360-854661 (+)
CBA/J MGP_CBAJ_G0017699
protein coding gene Chr11:1192445-1215556 (+)
DBA/2J MGP_DBA2J_G0017810
protein coding gene Chr11:822100-837531 (+)
FVB/NJ MGP_FVBNJ_G0017801
protein coding gene Chr11:859450-875319 (+)
LP/J MGP_LPJ_G0017880
protein coding gene Chr11:992725-1008138 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017827
protein coding gene Chr11:897240-912714 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018403
protein coding gene Chr11:958543-978456 (+)
PWK/PhJ MGP_PWKPhJ_G0017067
protein coding gene Chr11:819301-834932 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016863
protein coding gene Chr11:924483-939822 (+)
WSB/EiJ MGP_WSBEiJ_G0017340
protein coding gene Chr11:850075-865494 (+)



Homology
more
  • Human Ortholog
    GAL3ST1, galactose-3-O-sulfotransferase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GAL3ST1, galactose-3-O-sulfotransferase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CST
  • Links
    NCBI Gene ID: 9514
    neXtProt AC: NX_Q99999
    UniProt: Q99999

  • Chr Location
    22q12.2; chr22:30554635-30574588 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit hindlimb weakness and progressive ataxia beginning at six weeks of age. Homozygous males exhibit sterility with a block in spermatogenesis prior to the first meiotic division.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049721 Ensembl Gene Model | MGI Sequence Detail 15691 C57BL/6J ±  kb
    transcript ENSMUST00000063004 Ensembl | MGI Sequence Detail 1879 Not Applicable  
    polypeptide ENSMUSP00000058348 Ensembl | MGI Sequence Detail 423 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 9
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 4
      Gene Ontology 4
      Phenotypes 24
    • Earliest
      J:61464 Hirahara Y, et al., cDNA cloning, genomic cloning, and tissue-specific regulation of mouse cerebroside sulfotransferase. Eur J Biochem. 2000 Apr;267(7):1909-17
    • Latest
      J:242701 von Gerichten J, et al., Diastereomer-specific quantification of bioactive hexosylceramides from bacteria and mammals. J Lipid Res. 2017 Jun;58(6):1247-1258

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory