Mtmr1
Gene Detail

Symbol Name ID

Mtmr1 myotubularin related protein 1 MGI:1858271

Feature Type

protein coding gene

Genetic Map

Chromosome X

36.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

ChrX:71364760-71419196 bp, + strand From VEGA annotation of GRCm38   54437 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2840  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Mtmr1

Human homologs

Human Homolog		MTMR1, myotubularin related protein 1
NCBI Gene ID		8776
neXtProt AC		NX_Q13613
Human Chr (Location)		Xq28; chrX:149861869-149933575 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Female mice homozygous and male mice hemizygous for a gene disruption display normal morphology, clinical chemistry, hematology, and behavior.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	dephosphorylation
Component	cytoplasm, membrane, ...
Function	hydrolase activity, phosphatase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (215)    Tissues (178)    Images (59)
Theiler Stages: 21, 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	94
In situ reporter (knock in)	59
RT-PCR	62

cDNA source data(69)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(73) cDNA(69) Primer pair(4)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000017893 (Evidence)
Ensembl Gene Model	ENSMUSG00000015214 (Evidence)
Entrez Gene	53332 (Evidence)
UniGene	219672
DFCI	TC1576947, TC1607710, TC1676673
DoTS	DT.101149070, DT.101736049, DT.91337738, DT.91573366, DT.94199152, DT.99841317
NIA Mouse Gene Index	U019916
EC	3.1.3.-
Consensus CDS Project	CCDS30178.1
International Mouse Knockout Project Status	Mtmr1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017893	VEGA Gene Model | MGI Sequence Detail	54437	C57BL/6J
transcript	OTTMUST00000043273	VEGA | MGI Sequence Detail	4640	Not Applicable
polypeptide	OTTMUSP00000019453	VEGA | MGI Sequence Detail	671	Not Applicable

All sequences(74) RefSeq(2) UniProt(11)

Polymorphisms

SNPs(230 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004182	GRAM
InterPro	IPR017906	Myotubularin phosphatase domain
InterPro	IPR010569	Myotubularin-related
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR000387	Protein-tyrosine/Dual specificity phosphatase
InterPro	IPR016130	Protein-tyrosine phosphatase, active site
Protein Ontology	PR:000010731	myotubularin-related protein 1

References

(Earliest) J:62647 Laporte J, et al., Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human. Hum Mol Genet. 1998 Oct;7(11):1703-12
(Latest) J:185949 Licatalosi DD, et al., Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain. Genes Dev. 2012 Jul 15;26(14):1626-42
All references(31)

Other accession IDs

MGI:2147990