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Celsr3 Gene Detail
Summary
  • Symbol
    Celsr3
  • Name
    cadherin, EGF LAG seven-pass G-type receptor 3
  • Synonyms
    Adgrc3, flamingo, Fmi1, mKIAA0812
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858236
    NCBI Gene: 107934
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:108703519-108730168 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 59.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    47 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858236
protein coding gene Chr9:108703244-108730168 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035314
protein coding gene Chr9:110817322-110843950 (+)
A/J MGP_AJ_G0035293
protein coding gene Chr9:106749972-106778700 (+)
AKR/J MGP_AKRJ_G0035225
protein coding gene Chr9:109428690-109455317 (+)
BALB/cJ MGP_BALBcJ_G0035287
protein coding gene Chr9:106444326-106470975 (+)
C3H/HeJ MGP_C3HHeJ_G0034997
protein coding gene Chr9:109827740-109854375 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035807
protein coding gene Chr9:113838567-113865199 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032705
protein coding gene Chr9:104161604-104188460 (+)
CAST/EiJ MGP_CASTEiJ_G0034308
protein coding gene Chr9:109792904-109820914 (+)
CBA/J MGP_CBAJ_G0034965
protein coding gene Chr9:117860902-117887638 (+)
DBA/2J MGP_DBA2J_G0035126
protein coding gene Chr9:106205043-106231700 (+)
FVB/NJ MGP_FVBNJ_G0035074
protein coding gene Chr9:104971948-104999671 (+)
LP/J MGP_LPJ_G0035202
protein coding gene Chr9:111006013-111032629 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035113
protein coding gene Chr9:119415382-119442043 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035828
protein coding gene Chr9:109704234-109730902 (+)
PWK/PhJ MGP_PWKPhJ_G0034015
protein coding gene Chr9:106536553-106564175 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033850
protein coding gene Chr9:109769385-109798461 (+)
WSB/EiJ MGP_WSBEiJ_G0034429
protein coding gene Chr9:109596716-109623339 (+)



Homology
more
  • Human Ortholog
    CELSR3, cadherin EGF LAG seven-pass G-type receptor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CELSR3, cadherin EGF LAG seven-pass G-type receptor 3
  • Synonyms
    ADGRC3, CDHF11, EGFL1, FMI1, HFMI1, MEGF2, RESDA1
  • Links
    NCBI Gene ID: 1951
    neXtProt AC: NX_Q9NYQ7
    UniProt: Q9NYQ7

  • Chr Location
    3p21.31; chr3:48636463-48662886 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 6 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit neonatal lethality, abnormal neurvous system development, and abnormal respiratory system development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023473 Ensembl Gene Model | MGI Sequence Detail 26650 C57BL/6J ±  kb
    transcript ENSMUST00000213524 Ensembl | MGI Sequence Detail 11571 Not Applicable  
    polypeptide ENSMUSP00000150759 Ensembl | MGI Sequence Detail 3309 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 38
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 35
      Gene Ontology 8
      Phenotypes 34
    • Earliest
      J:59260 Fukunishi Y, et al., Prediction of human cDNA from its homologous mouse full-length cDNA and human shotgun database. FEBS Lett. 1999 Dec 31;464(3):129-32
    • Latest
      J:341694 Young TR, et al., Thalamocortical control of cell-type specificity drives circuits for processing whisker-related information in mouse barrel cortex. Nat Commun. 2023 Sep 28;14(1):6077

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory