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Caprin1 Gene Detail
Summary
  • Symbol
    Caprin1
  • Name
    cell cycle associated protein 1
  • Synonyms
    caprin-1, Gpiap1, MMGPIP137, RNG105
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858234
    NCBI Gene: 53872
  • Gene Overview
    MyGene.info: CAPRIN1
Location & Maps
more
  • Sequence Map
    Chr2:103762941-103797649 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34709 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 54.43 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CAPRIN1, cell cycle associated protein 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CAPRIN1, cell cycle associated protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GPIAP1, GPIP137, GRIP137, M11S1, p137GPI, RNG105
  • Links
    NCBI Gene ID: 4076
    neXtProt AC: NX_Q14444

  • Chr Location
    11p13; chr11:34051617-34102610 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    78
  • Chemically induced (other)
    1
  • Gene trapped
    69
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Caprin1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit decreased fetal size, bent posture, cyanosis, respiratory failure, and neonatal lethality with impaired neuronal network development and reduced dendritic localization of sodium potassium ATPase subunit isoform mRNAs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014878 VEGA Gene Model | MGI Sequence Detail 34709 C57BL/6J ±  kb
transcript OTTMUST00000035357 VEGA | MGI Sequence Detail 6169 Not Applicable  
polypeptide OTTMUSP00000015808 VEGA | MGI Sequence Detail 707 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    125 from dbSNP Build 142
Protein
Information
less
  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000005024 caprin-1
  • InterPro Domains
    IPR028816 Caprin
    IPR022070 Cytoplasmic activation/proliferation-associated protein-1 C term
Molecular
Reagents
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  • All nucleic 22
    cDNA 22

    Microarray probesets 9
Other
Accession IDs
less
MGI:2139127
References
more
  • Summaries
    All 46
    Developmental Gene Expression 7
    Gene Ontology 5
    Phenotypes 15
  • Earliest
    J:31588 Gessler M, et al., The gene encoding the GPI-anchored membrane protein p137GPI (M11S1) maps to human chromosome 11p13 and is highly conserved in the mouse. Genomics. 1996 Feb 15;32(1):169-70
  • Latest
    J:225905 Dash S, et al., Deficiency of the RNA binding protein caprin2 causes lens defects and features of peters anomaly. Dev Dyn. 2015 Oct;244(10):1313-27

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory