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Caprin1 Gene Detail
Summary
  • Symbol
    Caprin1
  • Name
    cell cycle associated protein 1
  • Synonyms
    caprin-1, Gpiap1, MMGPIP137, RNG105
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858234
    NCBI Gene: 53872
  • Gene Overview
    MyGene.info: CAPRIN1
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:103762945-103797640 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 54.43 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    125 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858234
protein coding gene Chr2:103762941-103797649 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026207
protein coding gene Chr2:105752128-105793510 (-)
A/J MGP_AJ_G0026168
protein coding gene Chr2:101393520-101428058 (-)
AKR/J MGP_AKRJ_G0026149
protein coding gene Chr2:104145313-104180580 (-)
BALB/cJ MGP_BALBcJ_G0026177
protein coding gene Chr2:101687474-101723027 (-)
C3H/HeJ MGP_C3HHeJ_G0025928
protein coding gene Chr2:104485794-104523191 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026628
protein coding gene Chr2:109293375-109336246 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024019
protein coding gene Chr2:97072795-97106301 (-)
CAST/EiJ MGP_CASTEiJ_G0025393
protein coding gene Chr2:104958846-104996274 (-)
CBA/J MGP_CBAJ_G0025906
protein coding gene Chr2:113020134-113054346 (-)
DBA/2J MGP_DBA2J_G0026043
protein coding gene Chr2:100956080-100991126 (-)
FVB/NJ MGP_FVBNJ_G0026005
protein coding gene Chr2:99954573-99990389 (-)
LP/J MGP_LPJ_G0026146
protein coding gene Chr2:105889244-105925652 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026031
protein coding gene Chr2:116954738-117003273 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026682
protein coding gene Chr2:104358373-104394736 (-)
PWK/PhJ MGP_PWKPhJ_G0025128
protein coding gene Chr2:100469257-100504128 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024929
protein coding gene Chr2:103574101-103608880 (-)
WSB/EiJ MGP_WSBEiJ_G0025460
protein coding gene Chr2:105064854-105102608 (-)



Homology
more
  • Human Ortholog
    CAPRIN1, cell cycle associated protein 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CAPRIN1, cell cycle associated protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GPIAP1, GPIP137, GRIP137, M11S1, p137GPI, RNG105
  • Links
    NCBI Gene ID: 4076
    neXtProt AC: NX_Q14444
    UniProt: Q14444

  • Chr Location
    11p13; chr11:34051617-34102610 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased fetal size, bent posture, cyanosis, respiratory failure, and neonatal lethality with impaired neuronal network development and reduced dendritic localization of sodium potassium ATPase subunit isoform mRNAs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53872 NCBI Gene Model | MGI Sequence Detail 34696 C57BL/6J ±  kb
    transcript NM_016739 RefSeq | MGI Sequence Detail 6181 C57BL/6  
    polypeptide Q60865 UniProt | EBI | MGI Sequence Detail 707 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 23

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:2139127
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 7
      Gene Ontology 5
      Phenotypes 16
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:254991 Nakayama K, et al., RNG105/caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation. Elife. 2017 Nov 21;6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory