Caprin1 MGI Mouse Gene Detail - MGI:1858234 - cell cycle associated protein 1

Symbol

Caprin1
Name

cell cycle associated protein 1
Synonyms

caprin-1, Gpiap1, MMGPIP137, RNG105

Feature Type

protein coding gene
IDs

MGI:1858234
NCBI Gene: 53872
Alliance

genome feature page
Transcription Start Sites

11 TSS

Sequence Map

Chr2:103593292-103627946 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 54.43 cM
Mapping Data

2 experiments

SNPs within 2kb

548 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858234	protein coding gene	Chr2:103593286-103627994 (-)
129S1/SvImJ	ENSMUSG00200002195	protein coding gene	Chr2:100410492-100444659 (-)
A/J	ENSMUSG00195000643	protein coding gene	Chr2:100586539-100620498 (-)
AKR/J	ENSMUSG00220001536	protein coding gene	Chr2:100336644-100370605 (-)
BALB/cJ	ENSMUSG00180018886	protein coding gene	Chr2:100387629-100421592 (-)
C3H/HeJ	ENSMUSG00175009787	protein coding gene	Chr2:100659888-100694050 (-)
C57BL/6NJ	ENSMUSG00215015155	protein coding gene	Chr2:100477297-100511466 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024019	protein coding gene	Chr2:97072795-97106301 (-)
CAST/EiJ	ENSTCUG00005001568	protein coding gene	Chr2:99744470-99778657 (-)
CBA/J	ENSMUSG00210001899	protein coding gene	Chr2:100665431-100699391 (-)
DBA/2J	ENSMUSG00185005502	protein coding gene	Chr2:100384495-100418451 (-)
FVB/NJ	ENSMUSG00205010042	protein coding gene	Chr2:99701540-99735919 (-)
JF1/MsJ	ENSUMUG00000019631	protein coding gene	Chr2:100069544-100103481 (-)
LP/J	ENSMUSG00230000763	protein coding gene	Chr2:102133800-102167758 (-)
NOD/ShiLtJ	ENSMUSG00190022683	protein coding gene	Chr2:100485008-100519374 (-)
NZO/HlLtJ	ENSMUSG00225008045	protein coding gene	Chr2:110033218-110067380 (-)
PWK/PhJ	ENSLUMG00010023080	protein coding gene	Chr2:100080353-100114287 (-)
SPRET/EiJ	ENSMSPG00010036164	protein coding gene	Chr2:102107697-102142535 (-)
WSB/EiJ	ENSIUOG00005001428	protein coding gene	Chr2:100178192-100212557 (-)

Human Ortholog

CAPRIN1, cell cycle associated protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CAPRIN1, cell cycle associated protein 1
Synonyms

CONDCAC, GPIAP1, GPIP137, GRIP137, M11S1, NEDLAAD, p137GPI, RNG105
Links

HGNC:6743

NCBI Gene ID: 4076

UniProt: Q14444
Chr Location

11p13; chr11:34051674-34102610 (+) GRCh38

MGI Vertebrate Homology

Caprin1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CAPRIN1
Gene Tree

Caprin1

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

80
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

64
Radiation induced

1
Targeted

9
Genomic Mutations

2 involving Caprin1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased fetal size, bent posture, cyanosis, respiratory failure, and neonatal lethality with impaired neuronal network development and reduced dendritic localization of sodium potassium ATPase subunit isoform mRNAs.

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All GO Annotations

61
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

658
Tissues

52
cDNA Data

23
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CAPRIN1

Xenbase caprin1

ZFIN caprin1a

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All Sequences

126
RefSeq

30
UniProt

9
CCDS

CCDS16481.1

Ensembl

ENSMUSG00000027184 (Evidence)
NCBI Gene

53872

			Length	Strain/Species	Flank
genomic	53872	NCBI Gene Model \| MGI Sequence Detail	34655	C57BL/6J	± kb
transcript	NM_001412577	RefSeq \| MGI Sequence Detail	6181	C57BL/6
polypeptide	Q60865	UniProt \| EBI \| MGI Sequence Detail	707	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000005024 caprin-1

(term hierarchy)
InterPro Domains

IPR028816 Caprin

IPR041637 Caprin-1 dimerization domain

IPR022070 Cytoplasmic activation/proliferation-associated protein-1 C term
GlyGen

Q60865 3 sites, 1 O-linked glycan (1 site)

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All nucleic 24

cDNA 23

Primer pair 1

Antibodies 1

Microarray probesets 9

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MGI:2139127

Summaries

All 66

Developmental Gene Expression 9

Gene Ontology 10

Phenotypes 21
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:390320 Liu Y, et al., Exposure to the prenatal enriched environment alters maternal gut microbiota and promotes embryonic neurodevelopment via activating the AHR-Src pathway. Sci China Life Sci. 2025 Jul;68(7):1964-1979

TSS for Caprin1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr25503	Chr2:103627962-103628007 (-)	-39 bp
Tssr25502	Chr2:103627937-103627957 (-)	-1 bp
Tssr586	Chr2:103627914-103627919 (-)	29 bp
Tssr25501	Chr2:103627334-103627433 (-)	562 bp
Tssr25500	Chr2:103627281-103627323 (-)	644 bp
Tssr25499	Chr2:103613504-103613517 (-)	14,435 bp
Tssr25498	Chr2:103609711-103609746 (-)	18,217 bp
Tssr25497	Chr2:103606299-103606317 (-)	21,638 bp
Tssr25496	Chr2:103603390-103603406 (-)	24,548 bp
Tssr25495	Chr2:103599223-103599251 (-)	28,709 bp
Tssr25494	Chr2:103596840-103596854 (-)	31,099 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24