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Caprin1 Gene Detail
Summary
  • Symbol
    Caprin1
  • Name
    cell cycle associated protein 1
  • Synonyms
    caprin-1, Gpiap1, MMGPIP137, RNG105
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858234
    NCBI Gene: 53872
  • Gene Overview
    MyGene.info: CAPRIN1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:103762941-103797649 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34709 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 54.43 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CAPRIN1, cell cycle associated protein 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CAPRIN1, cell cycle associated protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GPIAP1, GPIP137, GRIP137, M11S1, p137GPI, RNG105
  • Links
    NCBI Gene ID: 4076
    neXtProt AC: NX_Q14444
    UniProt: Q14444

  • Chr Location
    11p13; chr11:34051617-34102610 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased fetal size, bent posture, cyanosis, respiratory failure, and neonatal lethality with impaired neuronal network development and reduced dendritic localization of sodium potassium ATPase subunit isoform mRNAs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000014878 VEGA Gene Model | MGI Sequence Detail 34709 C57BL/6J ±  kb
    transcript OTTMUST00000035357 VEGA | MGI Sequence Detail 6169 Not Applicable  
    polypeptide OTTMUSP00000015808 VEGA | MGI Sequence Detail 707 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      125 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 23

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:2139127
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 7
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:254991 Nakayama K, et al., RNG105/caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation. Elife. 2017 Nov 21;6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory