Pkd2l2
Gene Detail

Symbol Name ID

Pkd2l2 polycystic kidney disease 2-like 2 MGI:1858231

Synonyms

Polycystin - L2, TRPP5

Feature Type

protein coding gene

Genetic Map

Chromosome 18

18.62 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr18:34409423-34442789 bp, + strand From NCBI annotation of GRCm38   33367 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Pkd2l2 ± 2 cM)

Protein SuperFamily: transient receptor potential cation channel, subfamily P
Gene Tree: Pkd2l2

Human ortholog

PKD2L2 polycystic kidney disease 2-like 2 NCBI Gene ID 27039
Human Synonyms: TRPP5
Human Chr5:137225125-137276156 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Mice homozygous for a targeted gene disruption display hyperactivity.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	ion transmembrane transport, ion transport, ...
Component	integral to membrane, membrane
Function	calcium ion binding, ion channel activity

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (106)    Tissues (54)    Images (6)
Theiler Stages: 25, 26, 28

Assay Type	Results
In situ reporter (knock in)	50
RT-PCR	56

cDNA source data(55)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(61) Genomic(1) cDNA(56) Primer pair(4)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000014503 (Evidence)
Entrez Gene	53871 (Evidence)
UniGene	445792
DFCI	TC1586251
DoTS	DT.110758936, DT.55116473, DT.87060033, DT.94158039, DT.97390128, DT.97412184
NIA Mouse Gene Index	U018540
Consensus CDS Project	CCDS29127.1
International Mouse Knockout Project Status	Pkd2l2

Sequences

Length	Strain/Species
genomic	53871	NCBI Gene Model | MGI Sequence Detail	33367	C57BL/6J
transcript	NM_016927	RefSeq | MGI Sequence Detail	2461	C57BL/6
polypeptide	Q9JLG4	UniProt | EBI | MGI Sequence Detail	621	Not Applicable

All sequences(31) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(192 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003915	Polycystic kidney disease type 2 protein
InterPro	IPR013122	Polycystin cation channel, PKD1/PKD2
Protein Ontology	PR:000012775	polycystic kidney disease 2-like 2 protein

Graphical View of Protein Domain Structure

References

(Earliest) J:61533 Guo L, et al., Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization. Genomics. 2000 Mar 15;64(3):241-51
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(29)