About   Help   FAQ
Sart3 Gene Detail
Summary
  • Symbol
    Sart3
  • Name
    squamous cell carcinoma antigen recognized by T cells 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858230
    NCBI Gene: 53890
  • Gene Overview
    MyGene.info: SART3
Location & Maps
more
  • Sequence Map
    Chr5:113742446-113772510 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30065 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 55.55 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SART3, squamous cell carcinoma antigen recognized by T-cells 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SART3, squamous cell carcinoma antigen recognized by T-cells 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DSAP1, P100, p110, p110(nrb), RP11-13G14, TIP110
  • Links
    NCBI Gene ID: 9733
    neXtProt AC: NX_Q15020

  • Chr Location
    12q24.1; chr12:108522214-108561389 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Gene trapped
    8
  • Radiation induced
    1
  • Targeted
    3
  • Transgenic
    1
  • Genomic Mutations
    2 involving Sart3
  • Incidental Mutations
Mice homozygous for a conditional allele activated in hematopoietic cells exhibit protection against the effects of 5-FU treatment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054497 VEGA Gene Model | MGI Sequence Detail 30065 C57BL/6J ±  kb
transcript OTTMUST00000135131 VEGA | MGI Sequence Detail 4447 Not Applicable  
polypeptide OTTMUSP00000071570 VEGA | MGI Sequence Detail 962 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    171 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000014462 squamous cell carcinoma antigen recognized by T-cells 3
  • InterPro Domains
    IPR003107 HAT (Half-A-TPR) repeat
    IPR008669 LSM-interacting domain
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR000504 RNA recognition motif domain
    IPR011990 Tetratricopeptide-like helical domain
Molecular
Reagents
less
  • All nucleic 148
    cDNA 146
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2141094
References
more
  • Summaries
    All 30
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:60863 Harada K, et al., Mouse homologue of the human SART3 gene encoding tumor-rejection antigen. Jpn J Cancer Res. 2000 Feb;91(2):239-47
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory