About   Help   FAQ
Ppp1r3c
Gene Detail
Symbol

Name
ID
Ppp1r3c
protein phosphatase 1, regulatory (inhibitor) subunit 3C
MGI:1858229
Synonyms
Ppp1r5, protein targeting to glicogen, PTG
Feature Type
protein coding gene
Genetic Map
Chromosome 19
31.89 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:36731731-36736604 bp, - strand
From NCBI annotation of GRCm38

  4874 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3938  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PPP1R3C
Protein SuperFamily: protein phosphatase 1, glycogen targeting subunit, animal type
Gene Tree: Ppp1r3c

Human
homologs
PPP1R3C, protein phosphatase 1, regulatory subunit 3C
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5507
neXtProt AC: NX_Q9UQK1

Human Synonyms: PPP1R5

Human Chr (Location): 10q23-q24; chr10:91628440-91633101 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice are embyronic lethal. Heterozygotes have reduced glycogen stores due to attenuated glycogen synthesis and exhibit progressiuve glucose intolerance, hyperinsulinemia, and insulin resistance.
 
Human Diseases Modeled in Mice Using Ppp1r3c (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Ppp1r3c interacts with 294 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process carbohydrate metabolic process, glycogen biosynthetic process, ...
Component cell, glycogen granule, ...
Function enzyme binding, phosphoprotein phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (70)    Tissues (54)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 68
RT-PCR 2
cDNA source data(36)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ppp1r3c.1, ppp1r3c.2 ; ZFIN ppp1r3ca    NEW 
Molecular
reagents
All nucleic(37) cDNA(36) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000067279 (Evidence)
Entrez Gene 53412 (Evidence)
UniGene 24724
DFCI TC1577893
DoTS DT.99690364
NIA Mouse Gene Index U038998
Consensus CDS Project CCDS37968.1
International Mouse Phenotyping Consortium Status Ppp1r3c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 53412 NCBI Gene Model | MGI Sequence Detail 4874 C57BL/6J ±  kb
transcript NM_016854 RefSeq | MGI Sequence Detail 2696 C57BL/6 
polypeptide Q7TMB3 UniProt | EBI | MGI Sequence Detail 317 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(65 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017434 Protein phosphatase 1, glycogen targeting subunit, Metazoa
InterPro IPR005036 Putative phosphatase regulatory subunit
Protein Ontology PR:000013126 protein phosphatase 1 regulatory subunit 3C
Graphical View of Protein Domain Structure
References
(Earliest) J:38865 Printen JA, et al., PTG, a protein phosphatase 1-binding protein with a role in glycogen metabolism. Science. 1997 Mar 7;275(5305):1475-8
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory