Ppp1r3c
Gene Detail

Symbol Name ID

Ppp1r3c protein phosphatase 1, regulatory (inhibitor) subunit 3C MGI:1858229

Synonyms

Ppp1r5, protein targeting to glicogen, PTG

Feature Type

protein coding gene

Genetic Map

Chromosome 19

31.89 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr19:36731731-36736604 bp, - strand From NCBI annotation of GRCm38   4874 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3938  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: protein phosphatase 1, glycogen targeting subunit, animal type
Gene Tree: Ppp1r3c

Human homologs

Human Homolog		PPP1R3C, protein phosphatase 1, regulatory subunit 3C
NCBI Gene ID		5507
neXtProt AC		NX_Q9UQK1
Human Synonyms		PPP1R5
Human Chr (Location)		10q23-q24; chr10:93388197-93392858 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous null mice are embyronic lethal. Heterozygotes have reduced glycogen stores due to attenuated glycogen synthesis and exhibit progressiuve glucose intolerance, hyperinsulinemia, and insulin resistance.

 
Human Diseases Modeled Using Mouse Ppp1r3c (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	carbohydrate metabolic process, glycogen biosynthetic process, ...
Component	glycogen granule, intracellular membrane-bounded organelle
Function	enzyme binding, phosphoprotein phosphatase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (70)    Tissues (54)    Images (20)
Theiler Stages: 17, 21, 23, 24, 28

Assay Type	Results
RNA in situ	68
RT-PCR	2

cDNA source data(36)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(37) cDNA(36) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000067279 (Evidence)
Entrez Gene	53412 (Evidence)
UniGene	24724
DFCI	TC1577893
DoTS	DT.99690364
NIA Mouse Gene Index	U038998
Consensus CDS Project	CCDS37968.1
International Mouse Knockout Project Status	Ppp1r3c

Sequences

Length	Strain/Species
genomic	53412	NCBI Gene Model | MGI Sequence Detail	4874	C57BL/6J
transcript	NM_016854	RefSeq | MGI Sequence Detail	2696	C57BL/6
polypeptide	Q7TMB3	UniProt | EBI | MGI Sequence Detail	317	Not Applicable

All sequences(15) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(52 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017434	Protein phosphatase 1, glycogen targeting subunit, Metazoa
InterPro	IPR005036	Putative phosphatase regulatory subunit
Protein Ontology	PR:000013126	protein phosphatase 1 regulatory subunit 3C

Graphical View of Protein Domain Structure

References

(Earliest) J:38865 Printen JA, et al., PTG, a protein phosphatase 1-binding protein with a role in glycogen metabolism. Science. 1997 Mar 7;275(5305):1475-8
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(35)