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Ppp1r3c
Gene Detail
 Symbol
Name
ID
Ppp1r3c
protein phosphatase 1, regulatory (inhibitor) subunit 3C
MGI:1858229
Synonyms Ppp1r5, protein targeting to glicogen, PTG
Feature Type protein coding gene
Genetic Map
Chromosome 19
31.89 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:36731731-36736604 bp, - strand
From NCBI annotation of GRCm38

  4874 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3938  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: protein phosphatase 1, glycogen targeting subunit, animal type
Gene Tree: Ppp1r3c

Human
homologs
Human Homolog PPP1R3C, protein phosphatase 1, regulatory subunit 3C
NCBI Gene ID 5507
neXtProt AC  NX_Q9UQK1
Human Synonyms  PPP1R5
Human Chr (Location)  10q23-q24; chr10:91628440-91633101 (-)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are embyronic lethal. Heterozygotes have reduced glycogen stores due to attenuated glycogen synthesis and exhibit progressiuve glucose intolerance, hyperinsulinemia, and insulin resistance.
 
Human Diseases Modeled Using Mouse Ppp1r3c (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process carbohydrate metabolic process, glycogen biosynthetic process, ...
Component cell, glycogen granule, ...
Function enzyme binding, phosphoprotein phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (70)    Tissues (54)    Images (20)
Theiler Stages: 17, 21, 23, 24, 28
Assay TypeResults
RNA in situ 68
RT-PCR 2
cDNA source data(36)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(37) cDNA(36) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000067279 (Evidence)
Entrez Gene53412 (Evidence)
UniGene24724
DFCITC1577893
DoTSDT.99690364
NIA Mouse Gene IndexU038998
Consensus CDS ProjectCCDS37968.1
International Mouse Knockout Project StatusPpp1r3c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 53412 NCBI Gene Model | MGI Sequence Detail 4874 C57BL/6J ±  kb
transcript NM_016854 RefSeq | MGI Sequence Detail 2696 C57BL/6 
polypeptide Q7TMB3 UniProt | EBI | MGI Sequence Detail 317 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(65 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017434 Protein phosphatase 1, glycogen targeting subunit, Metazoa
InterPro IPR005036 Putative phosphatase regulatory subunit
Protein Ontology PR:000013126 protein phosphatase 1 regulatory subunit 3C
Graphical View of Protein Domain Structure
References (Earliest) J:38865 Printen JA, et al., PTG, a protein phosphatase 1-binding protein with a role in glycogen metabolism. Science. 1997 Mar 7;275(5305):1475-8
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory