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Ppp1r3c Gene Detail
Summary
  • Symbol
    Ppp1r3c
  • Name
    protein phosphatase 1, regulatory subunit 3C
  • Synonyms
    Ppp1r5, protein targeting to glicogen, PTG
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858229
    NCBI Gene: 53412
  • Gene Overview
    MyGene.info: PPP1R3C
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:36731731-36736604 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4874 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 31.89 cM, cytoband C3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PPP1R3C, protein phosphatase 1 regulatory subunit 3C
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PPP1R3C, protein phosphatase 1 regulatory subunit 3C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PPP1R5, PTG
  • Links
    NCBI Gene ID: 5507
    neXtProt AC: NX_Q9UQK1
    UniProt: Q9UQK1

  • Chr Location
    10q23.32; chr10:91628440-91633101 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Ppp1r3c mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are embyronic lethal. Heterozygotes have reduced glycogen stores, attenuated glycogen synthesis, glucose intolerance, hyperinsulinemia and insulin resistance. Mice homozygous for a different knock-out allele exhibit normal lifespan with enhanced whole body insulin sensitivity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53412 NCBI Gene Model | MGI Sequence Detail 4874 C57BL/6J ±  kb
    transcript NM_016854 RefSeq | MGI Sequence Detail 2696 C57BL/6  
    polypeptide Q7TMB3 UniProt | EBI | MGI Sequence Detail 317 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      65 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000013126 protein phosphatase 1 regulatory subunit 3C
    • InterPro Domains
      IPR005036 CBM21 (carbohydrate binding type-21) domain
      IPR038175 CBM21 domain superfamily
      IPR017434 Protein phosphatase 1 regulatory subunit 3B/C/D, metazoa
      IPR030683 Protein phosphatase 1 regulatory subunit 3C
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 36
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:38865 Printen JA, et al., PTG, a protein phosphatase 1-binding protein with a role in glycogen metabolism. Science. 1997 Mar 7;275(5305):1475-8
    • Latest
      J:241869 Lopez-Soldado I, et al., Effects of hepatic glycogen on food intake and glucose homeostasis are mediated by the vagus nerve in mice. Diabetologia. 2017 Jun;60(6):1076-1083

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory