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Cdkl2 Gene Detail
Summary
  • Symbol
    Cdkl2
  • Name
    cyclin-dependent kinase-like 2 (CDC2-related kinase)
  • Synonyms
    5330436L21Rik, KKIAMRE, Kkm
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858227
    NCBI Gene: 53886
  • Gene Overview
    MyGene.info: CDKL2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:92006074-92043883 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      37810 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 45.73 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CDKL2, cyclin dependent kinase like 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CDKL2, cyclin dependent kinase like 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KKIAMRE, P56
  • Links
    NCBI Gene ID: 8999
    neXtProt AC: NX_Q92772
    UniProt: Q92772

  • Chr Location
    4q21.1; chr4:75576494-75630537 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000025604 VEGA Gene Model | MGI Sequence Detail 37810 C57BL/6J ±  kb
    transcript OTTMUST00000062998 VEGA | MGI Sequence Detail 4066 Not Applicable  
    polypeptide OTTMUSP00000031117 VEGA | MGI Sequence Detail 568 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      195 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • EC
    • InterPro Domains
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
    Molecular
    Reagents
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    • All nucleic 31
      cDNA 30
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2140927, MGI:2444811
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 17
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory