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Slc5a3
Gene Detail
Symbol

Name
ID
Slc5a3
solute carrier family 5 (inositol transporters), member 3
MGI:1858226
Synonyms
Smit1
Feature Type
protein coding gene
Genetic Map
Chromosome 16
53.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:92058322-92087473 bp, + strand
From VEGA annotation of GRCm38

  29152 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31412  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: SLC5A3
Gene Tree: Slc5a3

Human
homologs
SLC5A3, solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6526

Human Synonyms: BCW2, SMIT, SMIT1, SMIT2

Human Chr (Location): 21q22.12; chr21:34073523-34106262 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Genomic Mutations involving Slc5a3 (5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in lethality shortly after birth due to respiratory failure and abnormal development of peripheral nerves.
 
Interactions
Slc5a3 interacts with 513 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process inositol metabolic process, ion transport, ...
Component integral component of membrane, membrane
Function symporter activity, transporter activity
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (309)    Tissues (207)    Images (46)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 291
RT-PCR 18
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(1) cDNA(12) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000025870 (Evidence)
Ensembl Gene Model ENSMUSG00000089774 (Evidence)
Entrez Gene 53881 (Evidence)
DFCI TC1624031, TC1643390, TC1689259, TC1707019
DoTS DT.110720897, DT.40183204, DT.527442, DT.91404847
Consensus CDS Project CCDS37403.1
International Mouse Phenotyping Consortium Status Slc5a3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025870 VEGA Gene Model | MGI Sequence Detail 29152 C57BL/6J ±  kb
transcript OTTMUST00000063747 VEGA | MGI Sequence Detail 10913 Not Applicable 
polypeptide OTTMUSP00000031568 VEGA | MGI Sequence Detail 718 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(78 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001734 Sodium/solute symporter
InterPro IPR018212 Sodium/solute symporter, conserved site
InterPro IPR019900 Sodium/solute symporter, subgroup
Protein Ontology PR:000015170 sodium/myo-inositol cotransporter
References
(Earliest) J:61525 McVeigh KE, et al., Murine chromosome 16 telomeric region, homologous with human chromosome 21q22, contains the osmoregulatory Na(+)/myo-inositol cotransporter (SLC5A3) gene. Cytogenet Cell Genet. 2000;88(1-2):153-8
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(35)
Other
accession IDs
MGI:2683639, MGI:3035295

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory