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Tuba8 Gene Detail
Summary
  • Symbol
    Tuba8
  • Name
    tubulin, alpha 8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858225
    NCBI Gene: 53857
  • Gene Overview
    MyGene.info: TUBA8
Location & Maps
more
  • Sequence Map
    Chr6:121210696-121226854 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16159 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 57.15 cM, cytoband F1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TUBA8, tubulin alpha 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TUBA8, tubulin alpha 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TUBAL2
  • Links
    NCBI Gene ID: 51807
    neXtProt AC: NX_Q9NY65

  • Chr Location
    22q11.1; chr22:18110687-18131731 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 56766
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: TUBA8
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human TUBA8 associations

Human Disease Mouse Models
       Cortical Dysplasia, Complex, with Other Brain Malformations 8; CDCBM8   OMIM: 613180
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotype references
  • All Mutations and Alleles
    10
  • Endonuclease-mediated
    1
  • Gene trapped
    9
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Other Mouse Links
  • Other Vertebrate Links
    Xenbase tuba8
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022202 VEGA Gene Model | MGI Sequence Detail 16159 C57BL/6J ±  kb
transcript OTTMUST00000052759 VEGA | MGI Sequence Detail 2263 Not Applicable  
polypeptide OTTMUSP00000025057 VEGA | MGI Sequence Detail 449 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    55 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 23
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:61654 Stanchi F, et al., TUBA8: A new tissue-specific isoform of alpha-tubulin that is highly conserved in human and mouse. Biochem Biophys Res Commun. 2000 Apr 21;270(3):1111-8
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory