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Tuba8 Gene Detail
Summary
  • Symbol
    Tuba8
  • Name
    tubulin, alpha 8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858225
    NCBI Gene: 53857
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:121187655-121203813 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 57.15 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    55 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858225
protein coding gene Chr6:121187655-121209304 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031214
protein coding gene Chr6:124147833-124165323 (+)
A/J MGP_AJ_G0031183
protein coding gene Chr6:119364602-119381116 (+)
AKR/J MGP_AKRJ_G0031114
protein coding gene Chr6:122588785-122604705 (+)
BALB/cJ MGP_BALBcJ_G0031194
protein coding gene Chr6:119132510-119148675 (+)
C3H/HeJ MGP_C3HHeJ_G0030912
protein coding gene Chr6:122615904-122632703 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031652
protein coding gene Chr6:127325851-127341713 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028812
protein coding gene Chr6:116264695-116282493 (+)
CAST/EiJ MGP_CASTEiJ_G0030301
protein coding gene Chr6:123057173-123078142 (+)
CBA/J MGP_CBAJ_G0030877
protein coding gene Chr6:132386485-132402467 (+)
DBA/2J MGP_DBA2J_G0031033
protein coding gene Chr6:118256803-118272703 (+)
FVB/NJ MGP_FVBNJ_G0030985
protein coding gene Chr6:117400822-117417707 (+)
LP/J MGP_LPJ_G0031112
protein coding gene Chr6:124138360-124154254 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031019
protein coding gene Chr6:136323848-136341942 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031681
protein coding gene Chr6:122620924-122638407 (+)
PWK/PhJ MGP_PWKPhJ_G0030016
protein coding gene Chr6:117298200-117314655 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029845
protein coding gene Chr6:121362525-121377859 (+)
WSB/EiJ MGP_WSBEiJ_G0030384
protein coding gene Chr6:122912960-122930830 (+)



Homology
more
  • Human Ortholog
    TUBA8, tubulin alpha 8
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TUBA8, tubulin alpha 8
  • Synonyms
    CDCBM8, MACTHC2, TUBAL2
  • Links
    NCBI Gene ID: 51807
    neXtProt AC: NX_Q9NY65
    UniProt: Q9NY65

  • Chr Location
    22q11.21; chr22:18110100-18146683 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human TUBA8 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele appear neurologically normal, progress to adulthood and exhibit normal fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030137 Ensembl Gene Model | MGI Sequence Detail 16159 C57BL/6J ±  kb
    transcript ENSMUST00000032233 Ensembl | MGI Sequence Detail 2263 Not Applicable  
    polypeptide ENSMUSP00000032233 Ensembl | MGI Sequence Detail 449 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 6
      Phenotypes 6
    • Earliest
      J:61654 Stanchi F, et al., TUBA8: A new tissue-specific isoform of alpha-tubulin that is highly conserved in human and mouse. Biochem Biophys Res Commun. 2000 Apr 21;270(3):1111-8
    • Latest
      J:295179 Ramos SI, et al., Tuba8 Drives Differentiation of Cortical Radial Glia into Apical Intermediate Progenitors by Tuning Modifications of Tubulin C Termini. Dev Cell. 2020 Feb 24;52(4):477-491.e8

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory