Tuba8
Gene Detail

Symbol Name ID

Tuba8 tubulin, alpha 8 MGI:1858225

Feature Type

protein coding gene

Genetic Map

Chromosome 6

57.15 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr6:121210734-121226854 bp, + strand From VEGA annotation of GRCm38   16121 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56766  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tuba8

Human homologs

Human Homolog		TUBA8, tubulin, alpha 8
NCBI Gene ID		51807
neXtProt AC		NX_Q9NY65
Human Synonyms		TUBAL2
Human Chr (Location)		22q11.1; chr22:18593453-18614498 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TUBA8

Alleles and phenotypes

All alleles(9) : Gene trapped(9)

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	GTP catabolic process, microtubule-based process, ...
Component	cytoplasm, cytoskeleton, ...
Function	GTPase activity, GTP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (118)    Tissues (72)    Images (18)
Theiler Stages: 17, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	95
RT-PCR	23

cDNA source data(10)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000022202 (Evidence)
Ensembl Gene Model	ENSMUSG00000030137 (Evidence)
Entrez Gene	53857 (Evidence)
DFCI	TC1583212, TC1590920, TC1669151
DoTS	DT.485439, DT.94239265
NIA Mouse Gene Index	U007355
Consensus CDS Project	CCDS39615.1
International Mouse Knockout Project Status	Tuba8

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022202	VEGA Gene Model | MGI Sequence Detail	16121	C57BL/6J
transcript	OTTMUST00000052759	VEGA | MGI Sequence Detail	2225	Not Applicable
polypeptide	OTTMUSP00000025057	VEGA | MGI Sequence Detail	449	Not Applicable

All sequences(30) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(43 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002452	Alpha tubulin
InterPro	IPR000217	Tubulin
InterPro	IPR017975	Tubulin, conserved site
InterPro	IPR023123	Tubulin, C-terminal
InterPro	IPR018316	Tubulin/FtsZ, 2-layer sandwich domain
InterPro	IPR008280	Tubulin/FtsZ, C-terminal
InterPro	IPR003008	Tubulin/FtsZ, GTPase domain
Protein Ontology	PR:000016813	tubulin alpha-8 chain

References

(Earliest) J:61654 Stanchi F, et al., TUBA8: A new tissue-specific isoform of alpha-tubulin that is highly conserved in human and mouse. Biochem Biophys Res Commun. 2000 Apr 21;270(3):1111-8
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(26)