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Tuba8
Gene Detail
 Symbol
Name
ID
Tuba8
tubulin, alpha 8
MGI:1858225
Feature Type protein coding gene
Genetic Map
Chromosome 6
57.15 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:121210734-121226854 bp, + strand
From VEGA annotation of GRCm38

  16121 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56766  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tuba8

Human
homologs
Human Homolog TUBA8, tubulin, alpha 8
NCBI Gene ID 51807
neXtProt AC  NX_Q9NY65
Human Synonyms  TUBAL2
Human Chr (Location)  22q11.1; chr22:18110687-18131731 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TUBA8
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(9)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Tuba8 interacts with 81 markers (Mir22, Mir26a-1, Mir29b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process GTP catabolic process, microtubule-based process, ...
Component cytoplasm, cytoskeleton, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (118)    Tissues (81)    Images (18)
Theiler Stages: 17, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 95
RT-PCR 23
cDNA source data(10)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000022202 (Evidence)
Ensembl Gene ModelENSMUSG00000030137 (Evidence)
Entrez Gene53857 (Evidence)
DFCITC1583212, TC1590920, TC1669151
DoTSDT.485439, DT.94239265
NIA Mouse Gene IndexU007355
Consensus CDS ProjectCCDS39615.1
International Mouse Knockout Project StatusTuba8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022202 VEGA Gene Model | MGI Sequence Detail 16121 C57BL/6J ±  kb
transcript OTTMUST00000052759 VEGA | MGI Sequence Detail 2225 Not Applicable 
polypeptide OTTMUSP00000025057 VEGA | MGI Sequence Detail 449 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002452 Alpha tubulin
InterPro IPR000217 Tubulin
InterPro IPR017975 Tubulin, conserved site
InterPro IPR023123 Tubulin, C-terminal
InterPro IPR018316 Tubulin/FtsZ, 2-layer sandwich domain
InterPro IPR008280 Tubulin/FtsZ, C-terminal
InterPro IPR003008 Tubulin/FtsZ, GTPase domain
Protein Ontology PR:000016813 tubulin alpha-8 chain
References (Earliest) J:61654 Stanchi F, et al., TUBA8: A new tissue-specific isoform of alpha-tubulin that is highly conserved in human and mouse. Biochem Biophys Res Commun. 2000 Apr 21;270(3):1111-8
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(26)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory