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Sept9
Gene Detail
Symbol

Name
ID
Sept9
septin 9
MGI:1858222
Synonyms
Msf, MSF1, PNUTL4, Sint1, SL3-3 integration site 1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
82.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:117199661-117362325 bp, + strand
From VEGA annotation of GRCm38

  162665 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:90949  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: septin
Gene Tree: Sept9

Human
homologs
Human Homolog SEPT9, septin 9
NCBI Gene ID 10801
neXtProt AC  NX_Q9UHD8
Human Synonyms  AF17q25, MSF, MSF1, NAPB, PNUTL4, SeptD1, SINT1
Human Chr (Location)  17q25; chr17:77281410-77500596 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SEPT9
Mutations,
alleles, and
phenotypes
All mutations/alleles(270) : Gene trapped(265) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted allele exhibit embryonic lethality around E10 with generalized apoptotic degeneration.
 
Interactions
Sept9 interacts with 225 markers (Mir17, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cell cycle, cell division, ...
Component actin cytoskeleton, cytoplasm, ...
Function GTP binding, nucleotide binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (24)    Tissues (12)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 24
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) Genomic(1) cDNA(9)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000003788 (Evidence)
Ensembl Gene ModelENSMUSG00000059248 (Evidence)
Entrez Gene53860 (Evidence)
DFCITC1674571, TC1574203
DoTSDT.97375851, DT.97367011, DT.101147106, DT.101335815, DT.535253, DT.110506412, DT.101735780, DT.97408179
NIA Mouse Gene IndexU013591
Consensus CDS ProjectCCDS25684.1, CCDS48990.1, CCDS48991.1
International Mouse Knockout Project StatusSept9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003788 VEGA Gene Model | MGI Sequence Detail 162665 C57BL/6J ±  kb
transcript OTTMUST00000008318 VEGA | MGI Sequence Detail 3616 Not Applicable 
polypeptide OTTMUSP00000004043 VEGA | MGI Sequence Detail 583 Not Applicable 

For the selected sequences
All sequences(94) RefSeq(14) UniProt(9)
Polymorphisms
SNPs within 2kb(885 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000038 Cell division protein GTP binding
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR016491 Septin
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000014661 septin-9
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:205027 Lassen LB, et al., Septin9 is involved in T-cell development and CD8+ T-cell homeostasis. Cell Tissue Res. 2013 Jun;352(3):695-705
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory