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Sept9 Gene Detail
Summary
  • Symbol
    Sept9
  • Name
    septin 9
  • Synonyms
    Msf, MSF1, PNUTL4, Sint1, SL3-3 integration site 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858222
    NCBI Gene: 53860
Location & Maps
more
  • Sequence Map
    Chr11:117199661-117362325 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      162665 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SEPT9, septin 9
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SEPT9, septin 9
    Orthology source: HomoloGene
  • Synonyms
    AF17q25, MSF, MSF1, NAPB, PNUTL4, SeptD1, SINT1
  • Links
    NCBI Gene ID: 10801
    neXtProt AC: NX_Q9UHD8

  • Chr Location
    17q25; chr17:77281410-77500596 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SEPT9 associations

Human Disease Mouse Models
       Amyotrophy, Hereditary Neuralgic; HNA   OMIM: 162100
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 3 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit embryonic lethality around E10 with generalized apoptotic degeneration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003788 VEGA Gene Model | MGI Sequence Detail 162665 C57BL/6J ±  kb
transcript OTTMUST00000008318 VEGA | MGI Sequence Detail 3616 Not Applicable  
polypeptide OTTMUSP00000004043 VEGA | MGI Sequence Detail 583 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    885 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
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  • All nucleic 15
    Genomic 1
    cDNA 10
    Primer pair 2
    Other 2

    Microarray probesets 3
References
more
  • Summaries
    All 39
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 14
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:205027 Lassen LB, et al., Septin9 is involved in T-cell development and CD8+ T-cell homeostasis. Cell Tissue Res. 2013 Jun;352(3):695-705

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory