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Sept9 Gene Detail
Summary
  • Symbol
    Sept9
  • Name
    septin 9
  • Synonyms
    Msf, MSF1, PNUTL4, Sint1, SL3-3 integration site 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858222
    NCBI Gene: 53860
  • Gene Overview
    MyGene.info: SEPT9
  • Alliance
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:117199661-117362325 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 82.61 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    879 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858222
protein coding gene Chr11:117199661-117362325 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019446
protein coding gene Chr11:121408468-121594644 (+)
A/J MGP_AJ_G0019414
protein coding gene Chr11:116042648-116212045 (+)
AKR/J MGP_AKRJ_G0019384
protein coding gene Chr11:119581227-119757064 (+)
BALB/cJ MGP_BALBcJ_G0019389
protein coding gene Chr11:116421755-116591361 (+)
C3H/HeJ MGP_C3HHeJ_G0019195
protein coding gene Chr11:119860279-120036914 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019838
protein coding gene Chr11:125128960-125315782 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017463
protein coding gene Chr11:113068808-113230397 (+)
CAST/EiJ MGP_CASTEiJ_G0018749
protein coding gene Chr11:121286253-121458258 (+)
CBA/J MGP_CBAJ_G0019166
protein coding gene Chr11:130018746-130224084 (+)
DBA/2J MGP_DBA2J_G0019278
protein coding gene Chr11:115450288-115617087 (+)
FVB/NJ MGP_FVBNJ_G0019270
protein coding gene Chr11:115060409-115229013 (+)
LP/J MGP_LPJ_G0019348
protein coding gene Chr11:121747330-121932446 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019303
protein coding gene Chr11:129064273-129243615 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019877
protein coding gene Chr11:120224659-120400479 (+)
PWK/PhJ MGP_PWKPhJ_G0018514
protein coding gene Chr11:116794805-116975126 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018307
protein coding gene Chr11:119945639-120129342 (+)
WSB/EiJ MGP_WSBEiJ_G0018801
protein coding gene Chr11:120178226-120359113 (+)



Homology
more
  • Human Ortholog
    SEPT9, septin 9
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SEPT9, septin 9
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AF17q25, MSF, MSF1, NAPB, PNUTL4, SeptD1, SINT1
  • Links
    NCBI Gene ID: 10801
    neXtProt AC: NX_Q9UHD8
    UniProt: Q9UHD8

  • Chr Location
    17q25.3; chr17:77281410-77500596 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human SEPT9 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit embryonic lethality around E10 with generalized apoptotic degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 53860 NCBI Gene Model | MGI Sequence Detail 162665 C57BL/6J ±  kb
transcript NM_001113487 RefSeq | MGI Sequence Detail 3796 C57BL/6  
polypeptide Q80UG5 UniProt | EBI | MGI Sequence Detail 583 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    Genomic 1
    cDNA 11
    Primer pair 2
    Other 2

    Microarray probesets 3
References
more
  • Summaries
    All 41
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 14
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:205027 Lassen LB, et al., Septin9 is involved in T-cell development and CD8+ T-cell homeostasis. Cell Tissue Res. 2013 Jun;352(3):695-705

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory