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Rcan2
Gene Detail
 Symbol
Name
ID
Rcan2
regulator of calcineurin 2
MGI:1858219
Synonyms Csp2, Dscr1l1, MCIP2, ZAKI-4
Feature Type protein coding gene
Genetic Map
Chromosome 17
19.77 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:43801851-44039516 bp, + strand
From NCBI annotation of GRCm38

  237666 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:130985  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Rcan2

Human
homologs
Human Homolog RCAN2, regulator of calcineurin 2
NCBI Gene ID 10231
neXtProt AC  NX_Q14206
Human Synonyms  CSP2, DSCR1L1, MCIP2, RCN2, ZAKI4, ZAKI-4
Human Chr (Location)  6p12.3; chr6:46220730-46492067 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out alle exhibit decreased body weight and resistance to diet-induced obesity, steatosis, glucose intolerance, and insulin sensitivity.
 
Interactions
Rcan2 interacts with 339 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process calcineurin-NFAT signaling cascade, calcium-mediated signaling, ...
Component intracellular
Function nucleotide binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (31)    Tissues (31)    Images (9)
Theiler Stages: 19, 21, 23, 24, 28
Assay TypeResults
RNA in situ 29
RT-PCR 2
cDNA source data(32)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) cDNA(32) Primer pair(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000039601 (Evidence)
Entrez Gene53901 (Evidence)
UniGene251242
DFCITC1579537, TC1596182, TC1621079, TC1627184, TC1644778
DoTSDT.101221489, DT.101367272, DT.40156617, DT.55120090, DT.60100792, DT.99841327
NIA Mouse Gene IndexU043604
Consensus CDS ProjectCCDS28800.1, CCDS28801.1
International Mouse Knockout Project StatusRcan2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 53901 NCBI Gene Model | MGI Sequence Detail 237666 C57BL/6J ±  kb
transcript NM_207649 RefSeq | MGI Sequence Detail 3389 C57BL/6 
polypeptide Q9JHG2 UniProt | EBI | MGI Sequence Detail 197 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(1465 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006931 Calcipressin
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
Protein Ontology PR:000013830 calcipressin-2
Graphical View of Protein Domain Structure
References (Earliest) J:61529 Strippoli P, et al., A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2). Genomics. 2000 Mar 15;64(3):252-63
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory