About   Help   FAQ
Rcan2
Gene Detail
Symbol

Name
ID
Rcan2
regulator of calcineurin 2
MGI:1858219
Synonyms
Csp2, Dscr1l1, MCIP2, ZAKI-4
Feature Type
protein coding gene
Genetic Map
Chromosome 17
19.77 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:43801851-44039516 bp, + strand
From Ensembl annotation of GRCm38

  237666 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:130985  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: RCAN2
Gene Tree: Rcan2

Human
homologs
RCAN2, regulator of calcineurin 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10231
neXtProt AC: NX_Q14206

Human Synonyms: CSP2, DSCR1L1, MCIP2, RCN2, ZAKI4, ZAKI-4

Human Chr (Location): 6p12.3; chr6:46220730-46492067 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out alle exhibit decreased body weight and resistance to diet-induced obesity, steatosis, glucose intolerance, and insulin sensitivity.
 
Interactions
Rcan2 interacts with 338 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (31)    Tissues (31)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 29
RT-PCR 2
cDNA source data(32)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase rcan2    NEW 
Molecular
reagents
All nucleic(34) cDNA(32) Primer pair(2)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000039601 (Evidence)
Entrez Gene 53901 (Evidence)
UniGene 251242
DFCI TC1579537, TC1596182, TC1621079, TC1627184, TC1644778
DoTS DT.101221489, DT.101367272, DT.40156617, DT.55120090, DT.60100792, DT.99841327
NIA Mouse Gene Index U043604
Consensus CDS Project CCDS28800.1, CCDS28801.1
International Mouse Phenotyping Consortium Status Rcan2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039601 Ensembl Gene Model | MGI Sequence Detail 237666 C57BL/6J ±  kb
transcript ENSMUST00000044895 Ensembl | MGI Sequence Detail 3363 Not Applicable 
polypeptide ENSMUSP00000039473 Ensembl | MGI Sequence Detail 243 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(10) UniProt(3)
Polymorphisms
SNPs within 2kb(1465 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006931 Calcipressin
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
Protein Ontology PR:000013830 calcipressin-2
References
(Earliest) J:61529 Strippoli P, et al., A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2). Genomics. 2000 Mar 15;64(3):252-63
(Latest) J:216917 Fouillade C, et al., Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature. Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):76-86
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory