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Rcan2 Gene Detail
Summary
  • Symbol
    Rcan2
  • Name
    regulator of calcineurin 2
  • Synonyms
    Csp2, Dscr1l1, MCIP2, ZAKI-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858219
    NCBI Gene: 53901
  • Gene Overview
    MyGene.info: RCAN2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:43801351-44039516 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      238166 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 19.77 cM, cytoband C
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    RCAN2, regulator of calcineurin 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RCAN2, regulator of calcineurin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CSP2, DSCR1L1, MCIP2, RCN2, ZAKI4, ZAKI-4
  • Links
    NCBI Gene ID: 10231
    neXtProt AC: NX_Q14206
    UniProt: Q14206

  • Chr Location
    6p12.3; chr6:46220730-46492067 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    15 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out alle exhibit decreased body weight and resistance to diet-induced obesity, steatosis, glucose intolerance, and insulin sensitivity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039601 Ensembl Gene Model | MGI Sequence Detail 238166 C57BL/6J ±  kb
    transcript ENSMUST00000229744 Ensembl | MGI Sequence Detail 2914 Not Applicable  
    polypeptide ENSMUSP00000155082 Ensembl | MGI Sequence Detail 243 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1449 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR006931 Calcipressin
      IPR034921 Calcipressin-2
      IPR034919 Calcipressin-2, RNA recognition motif
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
    Molecular
    Reagents
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    • All nucleic 34
      cDNA 32
      Primer pair 2

      Microarray probesets 5
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 8
      Gene Ontology 4
      Phenotypes 8
    • Earliest
      J:61529 Strippoli P, et al., A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2). Genomics. 2000 Mar 15;64(3):252-63
    • Latest
      J:259652 Ding LC, et al., Rcan2 and estradiol independently regulate body weight in female mice. Oncotarget. 2017 Jul 18;8(29):48098-48109

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory