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Rwdd2b Gene Detail
Summary
  • Symbol
    Rwdd2b
  • Name
    RWD domain containing 2B
  • Synonyms
    ORF5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858215
    NCBI Gene: 53858
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:87230295-87237461 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 49.53 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    531 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858215
 protein coding gene Chr16:87230219-87237480 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022977
 protein coding gene Chr16:88149057-88156224 (-)
A/J MGP_AJ_G0022945
 protein coding gene Chr16:84085777-84092930 (-)
AKR/J MGP_AKRJ_G0022915
 protein coding gene Chr16:86640112-86647278 (-)
BALB/cJ MGP_BALBcJ_G0022947
 protein coding gene Chr16:84612249-84619415 (-)
C3H/HeJ MGP_C3HHeJ_G0022709
 protein coding gene Chr16:87202760-87209913 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023394
 protein coding gene Chr16:91016624-91023790 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020898
 protein coding gene Chr16:81938381-81946063 (-)
CAST/EiJ MGP_CASTEiJ_G0022231
 protein coding gene Chr16:87579236-87587187 (-)
CBA/J MGP_CBAJ_G0022678
 protein coding gene Chr16:94917226-94924392 (-)
DBA/2J MGP_DBA2J_G0022812
 protein coding gene Chr16:84008842-84016008 (-)
FVB/NJ MGP_FVBNJ_G0022787
 protein coding gene Chr16:83116238-83124023 (-)
LP/J MGP_LPJ_G0022881
 protein coding gene Chr16:87837711-87844878 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022806
 protein coding gene Chr16:99471229-99478380 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023412
 protein coding gene Chr16:87107175-87114341 (-)
PWK/PhJ MGP_PWKPhJ_G0021974
 protein coding gene Chr16:84118750-84126065 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021804
 protein coding gene Chr16:86637329-86645290 (-)
WSB/EiJ MGP_WSBEiJ_G0022279
 protein coding gene Chr16:87349887-87357039 (-)



Homology
more
  • Human Ortholog
    RWDD2B, RWD domain containing 2B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RWDD2B, RWD domain containing 2B
  • Synonyms
    C21orf6, GL011
  • Links
    NCBI Gene ID: 10069
    UniProt: P57060

  • Chr Location
    21q21.3; chr21:29004384-29019360 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotype references
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    816
  • Tissues
    97
  • cDNA Data
    22
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041079 Ensembl Gene Model | MGI Sequence Detail 7167 C57BL/6J ±  kb
transcript ENSMUST00000039101 Ensembl | MGI Sequence Detail 2009 Not Applicable  
polypeptide ENSMUSP00000049168 Ensembl | MGI Sequence Detail 290 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    cDNA 23
    Primer pair 3
    Other 2

    Microarray probesets 3
References
more
  • Summaries
    All 36
    Developmental Gene Expression 3
    Phenotypes 15
  • Earliest
    J:61438 Orti R, et al., Characterization of a novel gene, C21orf6, mapping to a critical region of chromosome 21q22.1 involved in the monosomy 21 phenotype and of its murine ortholog, orf5. Genomics. 2000 Mar 1;64(2):203-10
  • Latest
    J:361105 Tateossian H, et al., DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome. Elife. 2025;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory