Rwdd2b Gene Detail

Summary

• Symbol
  Rwdd2b
• Name
  RWD domain containing 2B
• Synonyms
  ORF5

• Feature Type
  protein coding gene
• IDs
  MGI:1858215
  NCBI Gene: 53858
• Gene Overview
  MyGene.info: RWDD2B
• Alliance
  gene page
• Transcription Start Sites
  2 TSS

Location &
Maps

• Sequence Map
  Chr16:87433407-87440573 bp, - strand
• From Ensembl annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 16, 49.53 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  42 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858215	protein coding gene	Chr16:87433331-87440592 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022977	protein coding gene	Chr16:88149057-88156224 (-)
A/J	MGP_AJ_G0022945	protein coding gene	Chr16:84085777-84092930 (-)
AKR/J	MGP_AKRJ_G0022915	protein coding gene	Chr16:86640112-86647278 (-)
BALB/cJ	MGP_BALBcJ_G0022947	protein coding gene	Chr16:84612249-84619415 (-)
C3H/HeJ	MGP_C3HHeJ_G0022709	protein coding gene	Chr16:87202760-87209913 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023394	protein coding gene	Chr16:91016624-91023790 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020898	protein coding gene	Chr16:81938381-81946063 (-)
CAST/EiJ	MGP_CASTEiJ_G0022231	protein coding gene	Chr16:87579236-87587187 (-)
CBA/J	MGP_CBAJ_G0022678	protein coding gene	Chr16:94917226-94924392 (-)
DBA/2J	MGP_DBA2J_G0022812	protein coding gene	Chr16:84008842-84016008 (-)
FVB/NJ	MGP_FVBNJ_G0022787	protein coding gene	Chr16:83116238-83124023 (-)
LP/J	MGP_LPJ_G0022881	protein coding gene	Chr16:87837711-87844878 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022806	protein coding gene	Chr16:99471229-99478380 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023412	protein coding gene	Chr16:87107175-87114341 (-)
PWK/PhJ	MGP_PWKPhJ_G0021974	protein coding gene	Chr16:84118750-84126065 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021804	protein coding gene	Chr16:86637329-86645290 (-)
WSB/EiJ	MGP_WSBEiJ_G0022279	protein coding gene	Chr16:87349887-87357039 (-)

Homology

• Human Ortholog
  RWDD2B, RWD domain containing 2B

• Vertebrate Orthologs
  10

• Human Ortholog
  RWDD2B, RWD domain containing 2B
  Orthology source: HomoloGene, HGNC
• Synonyms
  C21orf6, GL011
• Links
  HGNC:1302

  NCBI Gene ID: 10069

  neXtProt AC: NX_P57060

  UniProt: P57060

  
  
• Chr Location
  21q21.3; chr21:29005759-29019371 (-)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 9654
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: RWDD2B
• Protein SuperFamily
  uncharacterized protein with RWD domain, RWDD2 type
• Gene Tree
  Rwdd2b
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  11 phenotype references
  

• All Mutations and Alleles
  32
• Gene trapped
  27
• Targeted
  5
• Genomic Mutations
  2 involving Rwdd2b
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  29 strains or lines available

Gene Ontology
(GO)
Classifications

• External Resources
  FuncBase

Expression

• Assay Results
  110
• Tissues
  97
• cDNA Data
  22
• Literature Summary
  3

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase rwdd2b

Interactions

• Rwdd2b interacts with 97 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

Sequences &
Gene Models

• All Sequences
  35
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS37383.1
• UniGene
  162406

• Ensembl
  ENSMUSG00000041079 (Evidence)
• NCBI Gene
  53858

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000041079	Ensembl Gene Model | MGI Sequence Detail	7167	C57BL/6J
transcript	ENSMUST00000039101	Ensembl | MGI Sequence Detail	2009	Not Applicable
polypeptide	ENSMUSP00000049168	Ensembl | MGI Sequence Detail	290	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000032777 RWD domain-containing protein 2B
  (term hierarchy)
• InterPro Domains
  IPR010541 Domain of unknown function DUF1115
  IPR006575 RWD domain
  IPR016135 Ubiquitin-conjugating enzyme/RWD-like
  IPR017359 Uncharacterised conserved protein UCP038021, RWD

Molecular
Reagents

• All nucleic 28

  cDNA 23

  Primer pair 3

  Other 2

  
  

  Microarray probesets 3

References

• Summaries
  All 32

  Developmental Gene Expression 3

  Phenotypes 11
• Earliest
  J:61438 Orti R, et al., Characterization of a novel gene, C21orf6, mapping to a critical region of chromosome 21q22.1 involved in the monosomy 21 phenotype and of its murine ortholog, orf5. Genomics. 2000 Mar 1;64(2):203-10
• Latest
  J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383

TSS for Rwdd2b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr141936	Chr16:87440551-87440612 (-)	-9 bp
Tssr141935	Chr16:87440498-87440542 (-)	53 bp