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Clpp Gene Detail
Summary
  • Symbol
    Clpp
  • Name
    caseinolytic mitochondrial matrix peptidase proteolytic subunit
  • Synonyms
    D17Wsu160e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858213
    NCBI Gene: 53895
  • Gene Overview
    MyGene.info: CLPP
Location & Maps
more
  • Sequence Map
    Chr17:56990264-56996371 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6108 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 29.61 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    CLPP, caseinolytic mitochondrial matrix peptidase proteolytic subunit
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CLPP, caseinolytic mitochondrial matrix peptidase proteolytic subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DFNB81, PRLTS3
  • Links
    NCBI Gene ID: 8192
    neXtProt AC: NX_Q16740

  • Chr Location
    19p13.3; chr19:6361452-6368904 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Clpp mouse models; 1 with human CLPP associations

Human Disease Mouse Models
       Perrault Syndrome 3; PRLTS3   OMIM: 614129 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    54 phenotypes from 3 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Gene trapped
    14
  • Targeted
    2
Mice homozygous for a gene trap allele exhibit infertility, hearing loss, growth retardation, reduced activity, T cell activation, increased mitochondrial DNA and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 53895 NCBI Gene Model | MGI Sequence Detail 6108 C57BL/6J ±  kb
transcript NM_017393 RefSeq | MGI Sequence Detail 1207 C57BL/6  
polypeptide O88696 UniProt | EBI | MGI Sequence Detail 272 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    33 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 86
    cDNA 83
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-36154, MGI:107582, MGI:2146982
References
more
  • Summaries
    All 38
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 8
    Phenotypes 9
  • Earliest
    J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
  • Latest
    J:234481 Seiferling D, et al., Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt. EMBO Rep. 2016 Jul;17(7):953-64

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory