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Clpp Gene Detail
Summary
  • Symbol
    Clpp
  • Name
    caseinolytic mitochondrial matrix peptidase proteolytic subunit
  • Synonyms
    D17Wsu160e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858213
    NCBI Gene: 53895
  • Gene Overview
    MyGene.info: CLPP
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:56990264-56996371 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 29.61 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    33 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858213
protein coding gene Chr17:56990264-56996371 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023945
protein coding gene Chr17:58734672-58740750 (+)
A/J MGP_AJ_G0023903
protein coding gene Chr17:57111586-57117693 (+)
AKR/J MGP_AKRJ_G0023872
protein coding gene Chr17:57834465-57840572 (+)
BALB/cJ MGP_BALBcJ_G0023904
protein coding gene Chr17:56952042-56958149 (+)
C3H/HeJ MGP_C3HHeJ_G0023668
protein coding gene Chr17:58556657-58562820 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024350
protein coding gene Chr17:60998299-61004406 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021796
protein coding gene Chr17:53591672-53597491 (+)
CAST/EiJ MGP_CASTEiJ_G0023150
protein coding gene Chr17:58846010-58852031 (+)
CBA/J MGP_CBAJ_G0023644
protein coding gene Chr17:63398099-63404192 (+)
DBA/2J MGP_DBA2J_G0023772
protein coding gene Chr17:55809187-55815294 (+)
FVB/NJ MGP_FVBNJ_G0023738
protein coding gene Chr17:55378697-55385605 (+)
LP/J MGP_LPJ_G0023854
protein coding gene Chr17:59412360-59419157 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023766
protein coding gene Chr17:62843218-62849296 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024394
protein coding gene Chr17:58195569-58201676 (+)
PWK/PhJ MGP_PWKPhJ_G0022896
protein coding gene Chr17:55176780-55183153 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022707
protein coding gene Chr17:54962318-54970874 (+)
WSB/EiJ MGP_WSBEiJ_G0023216
protein coding gene Chr17:58812132-58818091 (+)



Homology
more
  • Human Ortholog
    CLPP, caseinolytic mitochondrial matrix peptidase proteolytic subunit
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CLPP, caseinolytic mitochondrial matrix peptidase proteolytic subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DFNB81, PRLTS3
  • Links
    NCBI Gene ID: 8192
    neXtProt AC: NX_Q16740
    UniProt: Q16740

  • Chr Location
    19p13.3; chr19:6361452-6368904 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Clpp mouse models; 1 with human CLPP associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    57 phenotypes from 3 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit infertility, hearing loss, growth retardation, reduced activity, T cell activation, increased mitochondrial DNA and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53895 NCBI Gene Model | MGI Sequence Detail 6108 C57BL/6J ±  kb
    transcript NM_017393 RefSeq | MGI Sequence Detail 1207 C57BL/6  
    polypeptide O88696 UniProt | EBI | MGI Sequence Detail 272 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000029361 ATP-dependent Clp protease proteolytic subunit, mitochondrial
    • EC
    • InterPro Domains
      IPR001907 ATP-dependent Clp protease proteolytic subunit
      IPR029045 ClpP/crotonase-like domain superfamily
      IPR033135 ClpP, histidine active site
      IPR023562 Clp protease proteolytic subunit /Translocation-enhancing protein TepA
      IPR018215 ClpP, Ser active site
    Molecular
    Reagents
    less
    • All nucleic 87
      cDNA 84
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36154, MGI:107582, MGI:2146982
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:261711 Becker C, et al., CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis. EMBO Rep. 2018 May;19(5)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory