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Col5a3
Gene Detail
 Symbol
Name
ID
Col5a3
collagen, type V, alpha 3
MGI:1858212
Synonyms Pro-alpha3(V)
Feature Type protein coding gene
Genetic Map
Chromosome 9
7.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:20770050-20815067 bp, - strand
From VEGA annotation of GRCm38

  45018 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9253  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Col5a3

Human
homologs
Human Homolog COL5A3, collagen, type V, alpha 3
NCBI Gene ID 50509
neXtProt AC  NX_P25940
Human Chr (Location)  19p13.2; chr19:9959561-10010471 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation show decreased pancreatic beta cell mass, hyperglycemia, hypoinsulinemia, impaired glucose tolerance, insulin resistance and impaired glucose uptake. Homozygous females show decreased susceptibility to diet-induced obesity and a thin hypodermal fat layer.
 
Interactions
Col5a3 interacts with 150 markers (Mir1b, Mir29a, Mir29b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cell-matrix adhesion, extracellular matrix organization
Component collagen trimer, collagen type V trimer, ...
Function heparin binding, proteoglycan binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (90)    Tissues (49)    Images (7)
Theiler Stages: 10, 17, 18, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 33
RNA in situ 36
Northern blot 4
RT-PCR 17
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) cDNA(24) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022343 (Evidence)
Ensembl Gene ModelENSMUSG00000004098 (Evidence)
Entrez Gene53867 (Evidence)
UniGene334994
DFCITC1583902
DoTSDT.50315156, DT.101146823
NIA Mouse Gene IndexU030560
Consensus CDS ProjectCCDS22883.1
International Mouse Knockout Project StatusCol5a3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022343 VEGA Gene Model | MGI Sequence Detail 45018 C57BL/6J ±  kb
transcript OTTMUST00000053292 VEGA | MGI Sequence Detail 6119 Not Applicable 
polypeptide OTTMUSP00000025338 VEGA | MGI Sequence Detail 1739 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(6) UniProt(3)
Polymorphisms PCR(1) : SNPs within 2kb(219 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008160 Collagen triple helix repeat
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR000885 Fibrillar collagen, C-terminal
InterPro IPR001791 Laminin G domain
Protein Ontology PR:000005718 collagen alpha-3(V) chain
References (Earliest) J:61325 Imamura Y, et al., The pro-alpha3(V) collagen chain. Complete primary structure, expression domains in adult and developing tissues, and comparison to the structures and expression domains of the other types V and XI procollagen chains. J Biol Chem. 2000 Mar 24;275(12):8749-59
(Latest) J:178171 Magenheim J, et al., Ngn3(+) endocrine progenitor cells control the fate and morphogenesis of pancreatic ductal epithelium. Dev Biol. 2011 Nov 1;359(1):26-36
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory