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Nptx2 Gene Detail
Summary
  • Symbol
    Nptx2
  • Name
    neuronal pentraxin 2
  • Synonyms
    narp, np2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858209
    NCBI Gene: 53324
  • Gene Overview
    MyGene.info: NPTX2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:144545902-144557478 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 84.58 cM, cytoband G2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    157 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858209
protein coding gene Chr5:144545887-144557478 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030350
protein coding gene Chr5:149911219-149926488 (+)
A/J MGP_AJ_G0030319
protein coding gene Chr5:143466209-143480548 (+)
AKR/J MGP_AKRJ_G0030251
protein coding gene Chr5:147941316-147953026 (+)
BALB/cJ MGP_BALBcJ_G0030336
protein coding gene Chr5:144737140-144752186 (+)
C3H/HeJ MGP_C3HHeJ_G0030047
protein coding gene Chr5:148778588-148790426 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030781
protein coding gene Chr5:155392426-155406101 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028000
protein coding gene Chr5:137243364-137254866 (+)
CAST/EiJ MGP_CASTEiJ_G0029452
protein coding gene Chr5:148333380-148344890 (+)
CBA/J MGP_CBAJ_G0030017
protein coding gene Chr5:161780462-161798126 (+)
DBA/2J MGP_DBA2J_G0030167
protein coding gene Chr5:143216848-143228283 (+)
FVB/NJ MGP_FVBNJ_G0030122
protein coding gene Chr5:142435816-142447436 (+)
LP/J MGP_LPJ_G0030253
protein coding gene Chr5:150500060-150511658 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030153
protein coding gene Chr5:164136345-164147790 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030821
protein coding gene Chr5:147842401-147854958 (+)
PWK/PhJ MGP_PWKPhJ_G0029167
protein coding gene Chr5:142342408-142354204 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029003
protein coding gene Chr5:145571930-145583421 (+)
WSB/EiJ MGP_WSBEiJ_G0029525
protein coding gene Chr5:148647543-148659819 (+)



Homology
more
  • Human Ortholog
    NPTX2, neuronal pentraxin 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    NPTX2, neuronal pentraxin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NARP, NP2, NP-II
  • Links
    NCBI Gene ID: 4885
    neXtProt AC: NX_P47972
    UniProt: P47972

  • Chr Location
    7q22.1; chr7:98617285-98629869 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1892
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NPTX2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation of this gene display a mild alteration in retinal ganglion cell innervation but are fertile with no obvious behavioral abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000059991 Ensembl Gene Model | MGI Sequence Detail 11577 C57BL/6J ±  kb
transcript ENSMUST00000071782 Ensembl | MGI Sequence Detail 2536 Not Applicable  
polypeptide ENSMUSP00000071687 Ensembl | MGI Sequence Detail 429 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-16454, MGI:99669
References
more
  • Summaries
    All 46
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:32198 Tsui CC, et al., Narp, a novel member of the pentraxin family, promotes neurite outgrowth and is dynamically regulated by neuronal activity. J Neurosci. 1996 Apr 15;16(8):2463-78
  • Latest
    J:258215 Xiao MF, et al., NPTX2 and cognitive dysfunction in Alzheimer's Disease. Elife. 2017 Mar 23;6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory