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Ech1 Gene Detail
Summary
  • Symbol
    Ech1
  • Name
    enoyl coenzyme A hydratase 1, peroxisomal
  • Synonyms
    dienoyl-CoA isomerase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858208
    NCBI Gene: 51798
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:28524763-28531664 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 16.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    61 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858208
 protein coding gene Chr7:28524642-28531672 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031963
 protein coding gene Chr7:27669841-27678265 (+)
A/J MGP_AJ_G0031941
 protein coding gene Chr7:26974660-26983542 (+)
AKR/J MGP_AKRJ_G0031873
 protein coding gene Chr7:27668745-27677554 (+)
BALB/cJ MGP_BALBcJ_G0031948
 protein coding gene Chr7:27132213-27139678 (+)
C3H/HeJ MGP_C3HHeJ_G0031667
 protein coding gene Chr7:28043926-28052294 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032412
 protein coding gene Chr7:28575392-28583980 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029464
 protein coding gene Chr7:28036034-28042966 (+)
CAST/EiJ MGP_CASTEiJ_G0031002
 protein coding gene Chr7:21364972-21373450 (+)
CBA/J MGP_CBAJ_G0031633
 protein coding gene Chr7:29849359-29874815 (+)
DBA/2J MGP_DBA2J_G0031785
 protein coding gene Chr7:26726261-26733281 (+)
FVB/NJ MGP_FVBNJ_G0031742
 protein coding gene Chr7:26810112-26816752 (+)
LP/J MGP_LPJ_G0031865
 protein coding gene Chr7:27996840-28004941 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031778
 protein coding gene Chr7:29314735-29323311 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032442
 protein coding gene Chr7:27149470-27157727 (+)
PWK/PhJ MGP_PWKPhJ_G0030727
 protein coding gene Chr7:21751019-21758319 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030560
 protein coding gene Chr7:18172171-18180914 (+)
WSB/EiJ MGP_WSBEiJ_G0031111
 protein coding gene Chr7:27517323-27526217 (+)



Homology
more
  • Human Ortholog
    ECH1, enoyl-CoA hydratase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ECH1, enoyl-CoA hydratase 1
  • Synonyms
    HPXEL
  • Links
    NCBI Gene ID: 1891
    neXtProt AC: NX_Q13011
    UniProt: Q13011

  • Chr Location
    19q13.2; chr19:38815422-38831857 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    766
  • Tissues
    94
  • cDNA Data
    261
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 51798 NCBI Gene Model | MGI Sequence Detail 6902 C57BL/6J ±  kb
    transcript NM_016772 RefSeq | MGI Sequence Detail 1138 Not Specified  
    polypeptide O35459 UniProt | EBI | MGI Sequence Detail 327 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000006877 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial
      (term hierarchy)
    • EC
      5.3.3.-
    • InterPro Domains
      IPR029045 ClpP/crotonase-like domain superfamily
      IPR045002 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase Ech1-like
      IPR014748 Enoyl-CoA hydratase, C-terminal
      IPR001753 Enoyl-CoA hydratase/isomerase
      IPR018376 Enoyl-CoA hydratase/isomerase, conserved site
    Molecular
    Reagents
    less
    • All nucleic 262
      cDNA 261
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141846
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:284490 Varum S, et al., Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation. Cell Stem Cell. 2019 Apr 4;24(4):637-653.e9
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    06/23/2022
    MGI 6.20     		The Jackson Laboratory