Ech1 MGI Mouse Gene Detail - MGI:1858208 - enoyl coenzyme A hydratase 1, peroxisomal

Symbol

Ech1
Name

enoyl coenzyme A hydratase 1, peroxisomal
Synonyms

dienoyl-CoA isomerase

Feature Type

protein coding gene
IDs

MGI:1858208
NCBI Gene: 51798
Gene Overview

MyGene.info: ECH1
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr7:28825338-28832239 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 16.94 cM
Mapping Data

2 experiments

SNPs within 2kb

71 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858208	protein coding gene	Chr7:28825217-28832247 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031963	protein coding gene	Chr7:27669841-27678265 (+)
A/J	MGP_AJ_G0031941	protein coding gene	Chr7:26974660-26983542 (+)
AKR/J	MGP_AKRJ_G0031873	protein coding gene	Chr7:27668745-27677554 (+)
BALB/cJ	MGP_BALBcJ_G0031948	protein coding gene	Chr7:27132213-27139678 (+)
C3H/HeJ	MGP_C3HHeJ_G0031667	protein coding gene	Chr7:28043926-28052294 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032412	protein coding gene	Chr7:28575392-28583980 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029464	protein coding gene	Chr7:28036034-28042966 (+)
CAST/EiJ	MGP_CASTEiJ_G0031002	protein coding gene	Chr7:21364972-21373450 (+)
CBA/J	MGP_CBAJ_G0031633	protein coding gene	Chr7:29849359-29874815 (+)
DBA/2J	MGP_DBA2J_G0031785	protein coding gene	Chr7:26726261-26733281 (+)
FVB/NJ	MGP_FVBNJ_G0031742	protein coding gene	Chr7:26810112-26816752 (+)
LP/J	MGP_LPJ_G0031865	protein coding gene	Chr7:27996840-28004941 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031778	protein coding gene	Chr7:29314735-29323311 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032442	protein coding gene	Chr7:27149470-27157727 (+)
PWK/PhJ	MGP_PWKPhJ_G0030727	protein coding gene	Chr7:21751019-21758319 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030560	protein coding gene	Chr7:18172171-18180914 (+)
WSB/EiJ	MGP_WSBEiJ_G0031111	protein coding gene	Chr7:27517323-27526217 (+)

Human Ortholog

ECH1, enoyl-CoA hydratase 1

Vertebrate Orthologs

10

Human Ortholog

ECH1, enoyl-CoA hydratase 1
Orthology source: HomoloGene, HGNC
Synonyms

HPXEL
Links

HGNC:3149

NCBI Gene ID: 1891

neXtProt AC: NX_Q13011

UniProt: Q13011
Chr Location

19q13.2; chr19:38815422-38831857 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 1069
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: ECH1
Protein SuperFamily

4-chlorobenzoate-CoA dehalogenase 30K chain
Gene Tree

Ech1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Gene trapped

6
Targeted

4
Find Mice (IMSR)

5 strains or lines available

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All GO Annotations

9
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

725
Tissues

94
cDNA Data

261
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ech1

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Ech1 interacts with 20 markers (Mir27a, Mir27b, Mir124a-1, ...) View All

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All Sequences

40
RefSeq

2
UniProt

2
CCDS

CCDS21057.1
UniGene

291776

Ensembl

ENSMUSG00000053898 (Evidence)
NCBI Gene

51798

			Length	Strain/Species	Flank
genomic	51798	NCBI Gene Model \| MGI Sequence Detail	6902	C57BL/6J	± kb
transcript	NM_016772	RefSeq \| MGI Sequence Detail	1138	Not Specified
polypeptide	O35459	UniProt \| EBI \| MGI Sequence Detail	327	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006877 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

(term hierarchy)
EC

5.3.3.-
InterPro Domains

IPR029045 ClpP/crotonase-like domain superfamily

IPR014748 Enoyl-CoA hydratase, C-terminal

IPR001753 Enoyl-CoA hydratase/isomerase

IPR018376 Enoyl-CoA hydratase/isomerase, conserved site

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All nucleic 262

cDNA 261

Primer pair 1

Microarray probesets 3

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MGI:2141846

Summaries

All 42

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 11
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:284490 Varum S, et al., Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation. Cell Stem Cell. 2019 Apr 4;24(4):637-653.e9

TSS for Ech1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65547	Chr7:28825202-28825215 (+)	-129 bp
Tssr65548	Chr7:28825273-28825285 (+)	-59 bp
Tssr65549	Chr7:28825301-28825314 (+)	-30 bp
Tssr65550	Chr7:28825318-28825363 (+)	3 bp
Tssr65553	Chr7:28830007-28830028 (+)	4,680 bp
Tssr65554	Chr7:28830087-28830092 (+)	4,752 bp
Tssr65555	Chr7:28830107-28830137 (+)	4,784 bp
Tssr65556	Chr7:28830142-28830156 (+)	4,811 bp
Tssr65557	Chr7:28831375-28831389 (+)	6,044 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/05/2021 MGI 6.16