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Map3k14
Gene Detail
 Symbol
Name
ID
Map3k14
mitogen-activated protein kinase kinase kinase 14
MGI:1858204
Synonyms Nik
Feature Type protein coding gene
Genetic Map
Chromosome 11
66.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:103219762-103267472 bp, - strand
From VEGA annotation of GRCm38

  47711 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2940  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: mitogen-activated protein kinase kinase kinase 14
Gene Tree: Map3k14

Human
homologs
Human Homolog MAP3K14, mitogen-activated protein kinase kinase kinase 14
NCBI Gene ID 9020
neXtProt AC  NX_Q99558
Human Synonyms  FTDCR1B, HS, HSNIK, NIK
Human Chr (Location)  17q21; chr17:45263121-45317048 (-)  GRCh38
Alleles
and
phenotypes
All alleles(7) : Targeted(3) Gene trapped(2) Spontaneous(1) Chemically induced(1)
 
Homozygotes for a spontaneous mutation exhibit deficiencies in cellular and humoral immunity, susceptibility to infections, absence of lymph nodes and Peyer's patches, failure of isotype switching, and inflammation of exocrine organs.
 
Human Diseases Modeled Using Mouse Map3k14 (2)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process activation of MAPKK activity, I-kappaB kinase/NF-kappaB signaling, ...
Component cytoplasm, intracellular
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (117)    Tissues (108)    Images (17)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 117
cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(9) cDNA(7) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000003049 (Evidence)
Ensembl Gene ModelENSMUSG00000020941 (Evidence)
Entrez Gene53859 (Evidence)
DFCITC1578259
DoTSDT.110534385, DT.97360425
EC2.7.11.25
PDB4G3C, 4G3E, 4G3F, 4G3G
Consensus CDS ProjectCCDS25516.1
International Mouse Knockout Project StatusMap3k14
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003049 VEGA Gene Model | MGI Sequence Detail 47711 C57BL/6J ±  kb
transcript OTTMUST00000006259 VEGA | MGI Sequence Detail 4246 Not Applicable 
polypeptide OTTMUSP00000002951 VEGA | MGI Sequence Detail 942 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(396 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017425 Mitogen-activated protein (MAP) kinase kinase kinase 14
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000010133 mitogen-activated protein kinase kinase kinase 14
References (Earliest) J:16865 Miyawaki S, et al., A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice. Eur J Immunol. 1994 Feb;24(2):429-34
(Latest) J:206490 Murray SE, Cell-intrinsic role for NF-kappa B-inducing kinase in peripheral maintenance but not thymic development of Foxp3+ regulatory T cells in mice. PLoS One. 2013;8(9):e76216
All references(136)
Other
accession IDs
MGD-MRK-18699, MGI:101874

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory