Map3k14
Gene Detail

Symbol Name ID

Map3k14 mitogen-activated protein kinase kinase kinase 14 MGI:1858204

Synonyms

Nik

Feature Type

protein coding gene

Genetic Map

Chromosome 11

66.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:103219762-103267472 bp, - strand From VEGA annotation of GRCm38   47711 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2940  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: mitogen-activated protein kinase kinase kinase 14
Gene Tree: Map3k14

Human homologs

Human Homolog		MAP3K14, mitogen-activated protein kinase kinase kinase 14
NCBI Gene ID		9020
neXtProt AC		NX_Q99558
Human Synonyms		FTDCR1B, HS, HSNIK, NIK
Human Chr (Location)		17q21; chr17:43340488-43394414 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(3) Gene trapped(2) Spontaneous(1) Chemically induced(1)
 

Homozygotes for a spontaneous mutation exhibit deficiencies in cellular and humoral immunity, susceptibility to infections, absence of lymph nodes and Peyer's patches, failure of isotype switching, and inflammation of exocrine organs.

 
Human Diseases Modeled Using Mouse Map3k14 (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	I-kappaB kinase/NF-kappaB cascade, immune response, ...
Component	cytoplasm, intracellular membrane-bounded organelle, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (117)    Tissues (108)    Images (17)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	117

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) cDNA(7) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000003049 (Evidence)
Ensembl Gene Model	ENSMUSG00000020941 (Evidence)
Entrez Gene	53859 (Evidence)
DFCI	TC1578259
DoTS	DT.110534385, DT.97360425
EC	2.7.11.25
PDB	4G3C, 4G3E, 4G3F, 4G3G
Consensus CDS Project	CCDS25516.1
International Mouse Knockout Project Status	Map3k14

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003049	VEGA Gene Model | MGI Sequence Detail	47711	C57BL/6J
transcript	OTTMUST00000006259	VEGA | MGI Sequence Detail	4246	Not Applicable
polypeptide	OTTMUSP00000002951	VEGA | MGI Sequence Detail	942	Not Applicable

All sequences(29) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(356 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017425	Mitogen-activated protein (MAP) kinase kinase kinase 14
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000010133	mitogen-activated protein kinase kinase kinase 14

References

(Earliest) J:16865 Miyawaki S, et al., A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice. Eur J Immunol. 1994 Feb;24(2):429-34
(Latest) J:195312 Mancino A, et al., I kappa B kinase alpha (IKKalpha) activity is required for functional maturation of dendritic cells and acquired immunity to infection. EMBO J. 2013 Mar 20;32(6):816-28
All references(131)

Other accession IDs

MGD-MRK-18699, MGI:101874