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Map3k14 Gene Detail
Summary
  • Symbol
    Map3k14
  • Name
    mitogen-activated protein kinase kinase kinase 14
  • Synonyms
    Nik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858204
    NCBI Gene: 53859
  • Gene Overview
    MyGene.info: MAP3K14
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:103219764-103267401 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 66.80 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    391 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858204
protein coding gene Chr11:103219762-103267472 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019261
protein coding gene Chr11:106277141-106329349 (-)
A/J MGP_AJ_G0019229
protein coding gene Chr11:101768117-101817407 (-)
AKR/J MGP_AKRJ_G0019198
protein coding gene Chr11:104902731-104950728 (-)
BALB/cJ MGP_BALBcJ_G0019203
protein coding gene Chr11:102235256-102283210 (-)
C3H/HeJ MGP_C3HHeJ_G0019012
protein coding gene Chr11:105132296-105180589 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019652
protein coding gene Chr11:109581695-109629397 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017278
protein coding gene Chr11:99175672-99224023 (-)
CAST/EiJ MGP_CASTEiJ_G0018566
protein coding gene Chr11:106150823-106198589 (-)
CBA/J MGP_CBAJ_G0018981
protein coding gene Chr11:114137792-114190386 (-)
DBA/2J MGP_DBA2J_G0019093
protein coding gene Chr11:101275111-101322919 (-)
FVB/NJ MGP_FVBNJ_G0019083
protein coding gene Chr11:100818924-100870104 (-)
LP/J MGP_LPJ_G0019162
protein coding gene Chr11:106786944-106839326 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019114
protein coding gene Chr11:113517931-113566622 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019690
protein coding gene Chr11:105287805-105336344 (-)
PWK/PhJ MGP_PWKPhJ_G0018329
protein coding gene Chr11:102347846-102397772 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018121
protein coding gene Chr11:105039401-105093041 (-)
WSB/EiJ MGP_WSBEiJ_G0018615
protein coding gene Chr11:105286385-105338608 (-)



Homology
more
  • Human Ortholog
    MAP3K14, mitogen-activated protein kinase kinase kinase 14
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAP3K14, mitogen-activated protein kinase kinase kinase 14
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FTDCR1B, HS, HSNIK, NIK
  • Links
    NCBI Gene ID: 9020
    neXtProt AC: NX_Q99558
    UniProt: Q99558

  • Chr Location
    17q21.31; chr17:45263119-45317064 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Map3k14 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    89 phenotypes from 7 alleles in 9 genetic backgrounds
    16 phenotypes from multigenic genotypes
    137 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous mutation exhibit deficiencies in cellular and humoral immunity, susceptibility to infections, absence of lymph nodes and Peyer's patches, failure of isotype switching, and inflammation of exocrine organs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53859 NCBI Gene Model | MGI Sequence Detail 47638 C57BL/6J ±  kb
    transcript NM_016896 RefSeq | MGI Sequence Detail 4173 C57BL/6  
    polypeptide Q9WUL6 UniProt | EBI | MGI Sequence Detail 942 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-18699, MGI:101874
    References
    more
    • Summaries
      All 176
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 9
      Phenotypes 137
    • Earliest
      J:16865 Miyawaki S, et al., A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice. Eur J Immunol. 1994 Feb;24(2):429-34
    • Latest
      J:266317 Parvatiyar K, et al., A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling. Nat Commun. 2018 Jul 17;9(1):2770

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory